|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among 200 outpatients with dementia and MCI whose NGF SNP rs6330 genotype was identified, those with A-MCI (n = 35) and early-stage AD (n = 67) were recruited and divided into three groups according to genotype (C/C: n = 58, C/T: n = 39, T/T: n = 5).
|
22301435 |
2011 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a follow-up analysis using an independent data set, we demonstrate a protective effect of this variant against risk of conversion to MCI or AD (p = 0.038) and against cognitive decline in individuals who develop dementia (p = 3.41 × 10<sup>-15</sup> ).
|
29130521 |
2017 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After 5 years of motor symptoms, 24% of participants met the criteria for MCI and 69% for dementia.
|
31678902 |
2020 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We used, firstly, a clinical cohort at a dementia clinic (National Health Insurance Service-Ilsan Hospital [NHIS-IH]; N = 211; 110 AD, 64 mild cognitive impairment [MCI], and 37 cognitively normal with subjective memory complaints [SMC]) to test the diagnostic models; and, secondly, Alzheimer's Disease Neuroimaging Initiative (ADNI)-2 to test the generalizability.
|
31150957 |
2019 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among 200 outpatients with dementia and MCI, 146 outpatients with mild AD or A-MCI were recruited and divided into two genotypic groups, valine homozygosity (Val/Val) and methionine (Met) carriers, based on the representative BDNF functional polymorphism Val66Met.
|
22699449 |
2012 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further analysis of the diagnostic subgroups suggested different variables were more strongly associated with IADL from group to group (apathy and depression for normal participants, apathy for MCI participants and for participants with dementia due to AD, but not for those with non-AD dementia).
|
29190312 |
2018 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among 215 outpatients with dementia and MCI, 155 with mild AD (n = 108) or A-MCI (n = 47) were recruited and divided into three genotypic groups based on the representative NT-3 functional polymorphisms rs6332 and rs6489630.
|
23075484 |
2012 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the absence of a specific phenotype, the diagnosis of MCI might identify PSP patients at greatest risk of developing dementia and should be considered further in the diagnostic assessment.
|
28881351 |
2017 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The proportion of A+T+N+ patients increased with syndrome severity (from 1% in SCD to 14% in MCI and 35% in dementia), while the opposite was true for A-T-N- (from 48% to 19% and 6%).
|
31597710 |
2019 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Diagnosis of dementia at follow-up (obtained using clinical diagnostic criteria) constituted the reference standard, and all the included aMCI patients were divided into two groups: the aMCI converters (MCI-C) and MCI nonconverters (MCI-NC).
|
31744965 |
2020 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
150 individuals with ET (109 Normal Cognition (ET-NC group), and 30 with MCI and 11 dementia (ET-CI group)) completed self-ratings and objective assessments of memory, language, and executive functioning.
|
28477687 |
2017 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is expected that future versions of cognitive screening tests, modified using a PBA, will highlight the benefits of attending to qualitative features of test performance when trying to identify subtle features suggestive of MCI and/or dementia.
|
29113605 |
2018 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
AD dementia risk in late MCI, in early MCI, and in subjective memory impairment.
|
23375567 |
2014 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The cross-sectional cohort included control subjects without dementia and patients with AD, and the longitudinal cohort included patients with MCI and patients with AD followed over a 2-year period.
|
29378650 |
2018 |
|
Dementia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seventy-seven individuals with pre-MCI and 180 CN elders were recruited from the pool of individuals registered at the National Research Center for Dementia in Gwangju, Korea.
|
30176706 |
2018 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that AD8 can show dementia and MCI when the cut-off values are ≥5 and 3-4, respectively, with a sensitivity of 100% and 81.67% and specificity of 96.3% and 93.59%.
|
29923472 |
2019 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We performed a systematic literature review on Subjective Cognitive Decline (SCD) in order to examine whether the resemblance of brain connectome and functional connectivity (FC) alterations in SCD with respect to MCI, AD and HC can help us draw conclusions on the progression of SCD to more advanced stages of dementia.
|
31401485 |
2019 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional subgroup analyses (MCI versus dementia, Aβ-positive versus Aβ-negative subjects) were performed.
|
30636731 |
2019 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A multivariate model based on the Disease State Index classifier incorporated the available baseline tests to predict progression to MCI or dementia over time.
|
30619929 |
2018 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Simultaneous multi-category classification analyses showed that the volume under the ROC surface (VUS) was 0.57 and that the derived optimal cut-off points were 2 and 8 for controls, MCI, and dementia.
|
29475235 |
2018 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although PD-MCI is a risk factor for developing Parkinson's disease dementia there is evidence to suggest that PD-MCI might consist of distinct subtypes with different pathophysiologies and prognoses.
|
25814509 |
2015 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Within four years, 42 (22.8%) MCI individuals in the clinical sample and 45 (10.3%) individuals in the population-based sample progressed to dementia.
|
29335040 |
2018 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
208 participants remained normal and 60 developed cognitive decline, consistent with a diagnosis of MCI or dementia.
|
25212916 |
2014 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Pre-MCI subjects showed accelerated rates of progression to MCI as compared to NCI subjects, but slower rates of progression to dementia than MCI subjects.
|
21422909 |
2011 |
|
Dementia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extending the discriminative validity analysis to cognitive impairment (both dementia and MCI, n = 162) only slightly reduced the discriminative validity of BASIC whereas the discriminative validity of the MMSE was substantially attenuated.
|
31389089 |
2019 |