|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colitis is associated with high interferon-gamma, arthritis with high interleukin-6.
|
10450519 |
1999 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We then demonstrated that NOD2-deficient mice adoptively transferred OVA-specific CD4+ T cells and that administered intrarectal ECOVA developed colitis associated with the expansion of OVA-specific CD4+ T cells producing IFN-gamma.
|
16949315 |
2006 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment of C3H.IL-10(-/-) mice with fenofibrate delayed the onset of colitis, decreased the colonic histopathology score, and decreased colonic expression of genes encoding the inflammatory cytokines interferon-gamma and interleukin (IL)-17.
|
17631136 |
2007 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
APP administration dampened the mRNA expression of IL-1β, TNF-α, IL-6, IL-17, IL-22, CXCL9, CXCL10, CXCL11, and IFN-γ in the colons of mice with colitis.
|
21693591 |
2011 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin (IL)-23, IL-17A, IL-17F, and interferon-gamma (IFN-γ) are important mediators of inflammatory colitis and are potential therapeutic targets in inflammatory bowel disease (IBD).
|
21994045 |
2012 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Absolute numbers of IL-17(+) or IFN-γ(+) CD4(+) T cells per colon were less in mice receiving Daikenchuto than in mice that received control feed, as both groups received naive CD4(+) T cells to induce colitis.
|
22610884 |
2012 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
[Nature 2010;464:1371-1375] recently reported the accumulation of IL-23-responsive innate lymphoid cells in the colon, the former capable of producing IL-17 and interferon γ and mediating innate colitis in mice.
|
22796792 |
2012 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Colonic tissue isolated from murine colitis revealed that levels of IL-10R1 and suppressor of cytokine signaling 3 were increased in the epithelium and coincided with increased tissue IFN-γ and IL-10 cytokines.
|
24367025 |
2014 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
CTD_human |
Involvement of TACE in colon inflammation: a novel mechanism of regulation via SIRT-1 activation.
|
24548422 |
2014 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we show that the NF-κB protein c-Rel regulates the inflammatory potential of colonic IFN-γ(+)Thy1(+) ILCs to induce anti-CD40-mediated colitis in rag1(-/-) mice.
|
25100292 |
2015 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
SEW2871 treatment attenuated established colitis associated with decreased CD4+ T cells in colon lamina propria and reduced TNF-α and IFN-γ levels.
|
25588868 |
2015 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Gene delivery with IFN-γ-expression plasmids enhances the therapeutic effects of MSCs on DSS-induced mouse colitis.
|
26153869 |
2015 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using a model of experimental colitis, we observed that mice lacking NFAT5 in T cells exhibited exacerbated intestinal colitis and enhanced expression of IFNγ in draining lymph nodes and colon.
|
27479742 |
2017 |
|
Colitis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Guided by an unbiased metabolomics screen, we identified tryptophan (Trp) metabolism as a major modifying pathway in interferon-γ (IFNγ)-dominant murine colitis.
|
28098246 |
2017 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Exposure of Interleukin 10 (il10)-deficient mice to cigarette smoke accelerated development of colitis and increased expression of interferon gamma in the small intestine compared to wild-type mice exposed to smoke.
|
28506689 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In a 2,4,6-trinitrobenzenesulfonic acid-induced colitis model, mice carrying VDR deletion in gut epithelial cells [VDRflox/flox (VDRf/f);Villin-Cre or VDRΔIEC] or in colonic epithelial cells (VDRf/f;CDX2-Cre or VDRΔCEC) developed more severe clinical colitis than VDRf/f control mice, characterized by more robust T-helper (TH)1 and TH17 responses, with greater increases in mucosal interferon (IFN)-γ+, interleukin (IL)-17+, and IFN-γ+IL-17+ T cells.
|
29228157 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Colitis-derived inflammatory mediators including interferon-γ and reactive oxygen species strongly inhibited Sirt6 protein expression in young adult mouse colonocyte (YAMC) cells.
|
29387864 |
2017 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
In the absence of IFNγ, intestinal inflammation in CD4 T cell recipient mice was associated with enhanced IL17 responses; consequently, targeting IL17 signaling in IFNγ-deficient mice reduced T cell-mediated colitis.
|
29416538 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
ITE also reversed the systemic and intestinal frequency of CD4<sup>+</sup> T cells during colitis and suppressed inflammatory cytokines including IFN-γ, TNF-α, IL-17, IL-6, and IL-1 as well as induced IL-10 levels.
|
29672155 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A model of TH17-associated ileal hyperplasia that requires both IL-17A and IFNγ to generate self-tolerance and prevent colitis.
|
29728642 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, these findings indicate that GILZ controls IFN-γ production in B cells, which also affects T cell activity, and increased production of IFN-γ by B and T cells in LP is associated with predisposition to inflammatory colitis in mice.
|
30083167 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, an activating mutation in Nlrp1a increases IL-18 and IFNγ production, and decreases colonic butyrate to exacerbate colitis.
|
30214011 |
2018 |
|
Colitis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Thus, our findings suggest that mTORC1 signaling downstream of IFNγ prevents epithelial DNA damage and cancer development during colitis.
|
30265974 |
2019 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To investigate the functions of CD1d-dependent invariant natural killer T (iNKT) cells in experimental colitis induced in Yeti mice with dysregulated expression of IFNγ, we generated iNKT cell-deficient Yeti/CD1d KO mice and compared colitis among WT, CD1d KO, Yeti, and Yeti/CD1d KO mice following DSS treatment.
|
30333822 |
2018 |
|
Colitis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mice given NPD-0414-2 and NPD-0414-24 developed a significantly less severe form of TNBS colitis and exhibited reduced expression of IFN-γ and increased expression of IL-22.
|
31031628 |
2019 |