|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Interferon-γ (IFNγ) has been identified as a common cause of various hematopoietic abnormalities, such as aplastic anemia.
|
31668371 |
2020 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
As a negative effector cytokine, interferon gamma (IFNγ) takes part in aplastic anemia through its inhibitory effect on hematopoiesis.
|
31141802 |
2019 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The concentration of interferon-γ and interleukin-17 in the AA group were higher (<i>p</i> = 0.004; <i>p</i> = 0.003), whereas the concentration of <i>TGF-β</i> decreased (<i>p</i> = 0.044).
|
31287345 |
2019 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Interferon-γ (IFN-γ) and tumor necrosis factor-α (TNF-α) have been implicated historically in the immune pathophysiology of aplastic anemia (AA) and other bone marrow (BM) failure syndromes.
|
30361263 |
2018 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
IFN-γ +874 A/T gene polymorphism is associated with the etiology of AA in Egyptian patients.
|
26214243 |
2016 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in TNF and IFNG are associated with clinical characteristics of aplastic anemia in Argentinean population.
|
25248876 |
2015 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
MGD |
IFN-γ causes aplastic anemia by altering hematopoietic stem/progenitor cell composition and disrupting lineage differentiation.
|
25342713 |
2014 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
The data suggest that AA occurs when IFN-γ inhibits the generation of myeloid progenitors and prevents lineage differentiation, as opposed to infiltration of activated T cells.
|
25342713 |
2014 |
|
Aplastic Anemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
Plasma IL-18, IFN-γ and IL-4 levels were measured in patients with newly diagnosed AA (n = 29), AA in remission (n = 22) and healthy subjects (n = 30) via enzyme-linked immunosorbent assay (ELISA).
|
23334427 |
2013 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Eight SNP loci in five cytokine genes, including tumor necrosis factor-alpha (TNF-α), interferon-gamma (IFN-γ), transforming growth factor-beta (TGF-β), interleukin-6 (IL-6), and IL-10, and aplastic anemia (AA) were assessed.
|
22800824 |
2012 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Interleukin-27 enhances the production of tumour necrosis factor-α and interferon-γ by bone marrow T lymphocytes in aplastic anaemia.
|
21506940 |
2011 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that alterations in KIR/KIR-L matching, such as increased 3DL2 and decreased 2DS1 mismatch, and in the polymorphisms of TGFβ1, IFN-γ, TNF- α and IL-10 may account for the propensity to immunemediated killing of hematopoietic stem cells and/or ineffective hematopoiesis characteristic of AA and MDS.
|
21561401 |
2011 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
This exploratory study concurred with prior studies indicating that polymorphisms in IFNG are related to AA susceptibility.
|
20953611 |
2011 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
The results showed that the frequency of IFN-γ +874 TT genotype in patients with aplastic anemia was significantly higher than the corresponding frequency in the healthy adults (42.6% vs. 17.6%, χ(2)=13.78, p=0.01).
|
20934357 |
2010 |
|
Aplastic Anemia
|
0.900 |
AlteredExpression
|
disease |
LHGDN |
Increased T cell immunoglobulin mucin-3 and its ligand in acquired aplastic anemia.
|
18485114 |
2008 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Blocking the transcription of the IFN-gamma gene with kinase inhibitors might lead to the development of novel therapeutic agents for patients with aplastic anemia and other autoimmune diseases.
|
16434488 |
2006 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
Comparison between the IFN-gamma transcriptome in normal CD34 cells and changes previously detected in CD34 cells from AA and PNH patients reveals the presence of many similarities that may reflect molecular signature of in vivo IFN-gamma exposure.
|
16131564 |
2006 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.
|
15327519 |
2004 |
|
Aplastic Anemia
|
0.900 |
GeneticVariation
|
disease |
BEFREE |
Homozygosis for (12) CA repeats in the first intron of the human IFN-gamma gene is significantly associated with the risk of aplastic anaemia in Caucasian population.
|
15327519 |
2004 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
BEFREE |
T cells from aplastic anemia (AA) patients secrete IFN-gamma in vitro, activated cytotoxic lymphocytes infiltrate aplastic bone marrow (BM), and IFN-gamma mRNA, not detected in normal BM, is present in BM from most AA patients.
|
8639773 |
1996 |
|
Aplastic Anemia
|
0.900 |
AlteredExpression
|
disease |
BEFREE |
In contrast, IFN-gamma mRNA was only demonstrable in BMMC from some patients with aplastic anemia, irrespective of a history of transfusions.
|
1586705 |
1992 |
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
HPO |
|
|
|
|
Aplastic Anemia
|
0.900 |
Biomarker
|
disease |
CTD_human |
|
|
|