Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These findings suggest that the increased peripheral B:9-23rPep-specific IFN-γ immunoreactivity reflects decreased functional β-cell mass and greater disease activity of type 1 diabetes.
|
31525445 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The serum levels of IL-2 and IFN-γ were lower in both groups with T1D compared to controls, whilst the level of IL-4 did not differ.
|
31560963 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interferon γ plays a critical role in the pathogenesis of type 1 diabetes.
|
30827273 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Similarly, Interferon γ (IFN-γ), and intracellular free Calcium Ion (ifCa2+) levels were increased in T1D MOs than in control MOs, but the difference did not reach a significant level.
|
31322069 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Through functional analysis of the encoding genes coexpressed by the three lncRNAs, we found these genes were mainly enriched in type 1 diabetes and autoimmune thyroid disease pathways, whereas in Gene Ontology (GO) function classification, they were also mainly enriched in the immune response, type I interferon signaling pathways, interferon-γ mediated signaling pathways, and so forth.
|
30317603 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The messenger RNA (mRNA) levels and contents of interleukin (IL)-10, IL-4, transforming growth factor (TGF)-β, IL-2, IL-17, and IFN-γ in patients with T1D, healthy volunteers, streptozotocin (STZ)-induced T1D rat model, the control rat, and Treg infusion rats were determined by reverse transcription polymerase chain reaction and the enzyme-linked immunosorbent assay, respectively.
|
31535398 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Moreover, the ratio of CCR6-CXCR3+ and CCR6+CXCR3- memory Tregs was altered and the frequency of proliferating Ki67-positive and IFN-γ producing memory Tregs was decreased in children with T1D.
|
30723474 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The prevalence in gestational diabetes of these autoimmune markers of type 1 diabetes (T1D) has been assessed in many studies, together with the risk of progression of AABs-positive GDM towards impaired glucose regulation (IFG or IGT) and overt diabetes after pregancy.
|
31053128 |
2019 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Pro-inflammatory cytokines, such as interleukin-1β and interferon-γ, secreted by the immune cells invading islets of Langerhans, contribute to pancreatic β-cell death in T1D.
|
29367588 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, serum IFN-γ levels were lower in T1D patients compared to controls (p = 0.03) while IL-4 and IL-10 were not different.
|
29774468 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our data revealed that IFN-γ +874T allele carriers [odds ratio (OR) = 1.87, p < 0.001] and TT homozygotes (OR = 1.28, p < 0.001) were significantly more susceptible to developing T1D than the A allele carriers.
|
29257900 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
A significant increase in the levels of interleukin-4 (IL-4), IL-10, and transforming growth factor-β, and a decrease in the levels of IL-17 and interferon-γ in concordance with the significant increase in the Treg cell ratio in splenic MNCs (P < 0.05) was shown in T1DM mice treated with AD-MSC's exosomes as compared to T1DM untreated mice.
|
30074271 |
2018 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
IL-18 and IFN-γ have also been implicated in the onset of different types of immune-mediate inflammatory conditions such as Type 1 Diabetes (T1D), Celiac disease (CD), rheumatoid arthritis (RA), obesity and systemic lupus erythematosus (SLE).
|
28673589 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
We studied helper T-lymphocyte reactivity against β-cell autoantigens by measuring production of the pro-inflammatory cytokine interferon-γ and the anti-inflammatory cytokine interleukin-10, using enzyme-linked immunospot assays in 61 people with Type 1 diabetes (within 3 months of diagnosis, positive for HLA DRB1*0301 and/or *0401), of whom 33 were children/adolescents, and a further 91 were unaffected siblings.
|
27151105 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we observed a clear association between CRTAM expression and IFN-γ production in iNKT cells from healthy subjects and patients with type 1 diabetes.
|
27835062 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, intrinsic mitochondrial dysfunction observed in type 1 diabetes alters mitochondrial ATP and IFNγ production; the latter is correlated with ROS generation.
|
28883439 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of Panx2, but not Panx1, was downregulated by interleukin-1β (IL-1β) plus interferon-γ (IFNγ), two pro-inflammatory cytokines suggested to contribute to β-cell demise in type 1 diabetes (T1D). siRNA-mediated knockdown (KD) of Panx2 aggravated cytokine-induced apoptosis in rat INS-1E cells and primary rat β-cells, suggesting anti-apoptotic properties of Panx2.
|
28390953 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Following insulin stimulation, LADA group secreted higher concentration of interleukin-17 (IL-17) (P=0.02) and had higher proportion of interferon gamma (IFN-γ) secretors (P<0.001) than T1DM group.
|
29067979 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Importantly, IFN-γ exposure during activation reduced the cytotoxicity of human-origin type 1 diabetes-relevant autoreactive CD8<sup>+</sup> T cells.
|
27920091 |
2017 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Two-thirds of 46 GWAS candidate genes examined were expressed in human islets, and 11 of these significantly changed expression levels following exposure to proinflammatory cytokines (IL-1β + IFNγ + TNFα) for 48 h. Using the GWAS single nucleotide polymorphisms (SNPs) from each locus, we constructed a genetic risk score based on the cumulative number of risk alleles carried in children with newly diagnosed T1D.
|
26904692 |
2016 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
A high proportion of new-onset T1D subjects mounted an inflammatory IFN-γ response much more frequently to one of the mimotope peptides than to the natural peptide.
|
25831495 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Type 1 Diabetes (T1D) is an autoimmune disease where local release of cytokines such as IL-1β and IFN-γ contributes to β-cell apoptosis.
|
24462878 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
T cells secreting the cytokines IFN-γ and IL-10 in response to seven peptides known to elicit T cell responses in type 1 diabetes were quantified by cytokine ELISPOT in HLA-typed patients characterized for Abs to IA-2 epitopes.
|
25225671 |
2014 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
IGRP(265-273)-specific CD8 T-cells that were cloned from the peripheral blood of a recent onset T1D individual were shown to secrete IFNγ and Granzyme B after antigen-specific activation and lyse HLA-A2-expressing murine islets in-vitro.
|
23155466 |
2012 |
Diabetes Mellitus, Insulin-Dependent
|
0.600 |
Biomarker
|
disease |
BEFREE |
Association between age, IL-10, IFNγ, stimulated C-peptide and disease progression in children with newly diagnosed Type 1 diabetes.
|
22150609 |
2012 |