|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Concomitant neutralization of IFN-γ and IL-6 significantly reduced the degree of pneumonia as well as bacteremia compared to the control group, indicating a positive effect for the host during secondary bacterial infection.
|
31474978 |
2019 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Our in vivo results demonstrated that Gln treatment reduced ET release (as indicated by cell-free-DNA content and myeloperoxidase activity), decreased lung inflammation (reductions in interferon-γ and increases in interleukin-10 levels), and improved lung morpho-function (decreased static lung elastance and alveolar collapse) in comparison with ARDS animals treated with saline.
|
31013737 |
2019 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These data identified Ly6C+ CD8+ T lymphocytes as a source of IFN-γ in innate immunity and partially associated with reduced IFN-γ production, M2 polarization, and high mortality in anti-Gr-1 antibody-treated mice with L. pneumophila pneumonia.
|
30021216 |
2018 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
After treatment for 120 h, the D-dimer and INF-γ levels in both pneumonia groups were lower than those before treatment (p<0.001).
|
30546408 |
2018 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Notably, sensitization of IL-10-deficient mice with OVA/Alum/CpG resulted in the development of neutrophilic lung inflammation associated with IFNγ production.
|
28220116 |
2017 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that KB treatment attenuated cigarette smoke-induced lung inflammation as shown by reductions in levels of BAL IFNγ, CXCL9, CXCL10, CCL5, IL-6, G-CSF, and IL-17.
|
28506308 |
2017 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The serum concentrations of tumor necrosis factor alpha (median 114.5 pg/ml, range 49.1-897.9 pg/ml) and interferon gamma (median 376.9 pg/ml, range 221.4-1997.6 pg/ml) were significantly higher in children with RMPP compared to children with NRMPP.
|
25449230 |
2014 |
|
Pneumonia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Functional polymorphisms of interferon-gamma affect pneumonia-induced sepsis.
|
24475220 |
2014 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Pulmonary inflammation in mice with collagen-induced arthritis is conditioned by complete Freund's adjuvant and regulated by endogenous IFN-γ.
|
22930199 |
2012 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Regulation of neutrophils by interferon-γ limits lung inflammation during tuberculosis infection.
|
21967766 |
2011 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IFN-γ mRNA levels were reduced in the pneumonia group (2.48; 1.20-3.20) compared with nonpneumonia group (2.81; 2.10-3.26) (P=03) day 5 postsurgery.
|
20829336 |
2011 |
|
Pneumonia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The fatal lung inflammation is associated with high-level induction of interferon-gamma and its inducible inflammatory chemokines, suggesting the involvement of a T-helper-1 immune response.
|
20363924 |
2010 |