IFNG, interferon gamma, 3458

N. diseases: 1519; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE We have previously described a model of chronic alcohol ingestion followed by sepsis from cecal ligation and puncture in which alcohol-fed septic mice have higher mortality than water-fed septic mice, associated with altered gut integrity and increased production of TNF and IFNγ by splenic CD4 T cells without alterations in CD8 T cell function. 29664837 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE IFNγ secretion [enzyme-linked immunospot (ELISpot)] in response to stimulation with cytomegalovirus (CMV), pokeweed mitogen (PWM), muromonab-anti-CD3 (OKT3), and human leukocyte antigen (HLA)-DRA-mRNA expression and serum cytokine concentrations were repeatedly [<i>days 1</i>, <i>3</i>, <i>5</i>, and <i>7</i> after intensive care unit (ICU) admission] determined in patients with sepsis (<i>n</i> = 7) and patients undergoing major abdominal surgery (radical prostatectomy, cystectomy, <i>n</i> = 10). 31545153 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Guided by clinical and immunological monitoring, adjunctive immunotherapy with IFNγ appears well-tolerated in our cases and improves immune host defense in sepsis induced immuno suppression. 31690258 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Treatment with Recombinant Interleukin-15 (IL-15) Increases the Number of T Cells and Natural Killer (NK) Cells and Levels of Interferon-γ (IFN-γ) in a Rat Model of Sepsis. 31201735 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Sepsis was associated with high levels of IL-6, IL-10, G-CSF, and MCP1 and low levels of IFNγ, early sepsis with high levels of IL-6 and G-CSF, severe sepsis with high levels of IL-6 and IL-10, while deaths or sequelae was associated with low levels of IL-4, IL-12, IFNγ, and high levels of GM-CSF. 29562764 2019
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Alternatively, excessive NK cell activation and IFN-γ production can amplify the systemic inflammatory response during sepsis resulting in increased physiological dysfunction and organ injury. 29064085 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Our data showed that IL-33 attenuates mortality by promoting IFN-γ production in sepsis. 29610934 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Compared with healthy children, children with sepsis demonstrated lower LPS-induced TNF-α production (P < 0.0001) and lower phytohemagglutinin-induced IFN-γ production (P < 0.0001). 29470918 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE We recruited SIRS (n = 33) and sepsis (n = 89) patients from electronic medical records (EMR) according to whether data on PCT, CRP, interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-13, IL-17, IL-22, TNF-α, and IFN-γ levels were available. 30547887 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE S158A-KI mice were more susceptible to sepsis due to a marked reduction in IL-1β, TNF-α, and IFN-γ production accompanied by an inability to clear bacteria and recruit leukocytes. 29733298 2018
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE We demonstrated that spleen-derived IFN-γ induces generation of PD-L1<sup>+</sup>-suppressive neutrophils, implying that the spleen is critically involved in immune suppression during inflammatory diseases such as sepsis. 28974543 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE In this prospective study, Th1/Th2 cytokines, including IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ, were analyzed in patients with EBV-HLH or sepsis at the onset of disease by flow cytometry. 28222313 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE In the sepsis astrocyte models established by co-incubation of LPS and IFN-γ and astrocytes of the cerebral cortex of the rats, the mitochondria with a minor injury in the 6 h group (2.97± 0.92) increased significantly when compared with those in the 0 h group (1.08±0.95), 12 h group (1.70±1.01), and 24 h group (1.59±0.55) (p<0.05); the concentration of adenosine triphosphate (ATP) in the astrocytes of the cerebral cortex of the rats in the 6 h, 12 h, and 24 h groups increased significantly when compared with that in the 0 h group (p<0.05). 28975969 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Secondary outcome was to assess the following serum cytokine levels: interferon-γ (IFN-γ), interleukin (IL)-10, IL-1β, and tumor necrosis factoralpha (TNFα) at the baseline before LPS injection, 0 hour after LPS injection, and at 2, 4, 24 hours after induction of sepsis (RIC was performed at 2 h after LPS injection). 28601305 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE Interestingly, these data mirrored our observation in septic patients, in which sepsis severity was positively correlated to increased levels of IFN-γ in patients who were serologically positive for <i>T. gondii</i>. 28439500 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Natural killer (NK) cells play a crucial role in the pathophysiology of sepsis, leading to exaggerated inflammation due their rapid response and production of pro-inflammatory cytokines such as interferon gamma (IFN-γ). 28287491 2017
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE Because interferon-gamma (IFN-γ) plays an important role in inflammation, this work assessed IFN-γ single nucleotide polymorphism (SNPs) that may be associated with sepsis. 24475220 2014
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease BEFREE Using an in vitro model of endotoxin tolerance (ET), a pivotal feature of sepsis-induced immunosuppression in monocytes, we identified using gene expression profiling by microarray a panel of transcripts associated with the development of ET which expression was restored after immunostimulation with interferon-gamma (IFN-γ). 23874546 2013
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 AlteredExpression disease BEFREE IL-7 protein levels were similar in all groups.In cultured PBLs, IFN-γ gene expression was decreased in response to LPS and increased in response to CD3ab with sepsis: IL-7 gene expression increased in response to LPS in controls and to CD3ab with sepsis; Bcl-2 gene expression decreased in response to combined CD3ab and IL-2 with sepsis. 21711552 2011
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 GeneticVariation disease BEFREE This study evaluates the relationship between polymorphisms in the first intron of the interferon-gamma gene and the development of sepsis after trauma. 12219025 2002
CUI: C0036690
Disease: Septicemia
Septicemia
0.400 Biomarker disease CTD_human Ketamine inhibits the proinflammatory cytokine-induced reduction of cardiac intracellular cAMP accumulation. 9806674 1998