|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension was positively predicted by a BMI ≥ 30 kg/m<sup>2</sup> (HR 2.64, p 0.00) and IGF-I SDS values (HR 2.26, p 0.00).
|
31440920 |
2020 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor antigen (vWF<sub>ag</sub>)) are associated with IGF-1 in a healthy study population forming part of the larger African Prospective study on the Early Detection and Identification of Cardiovascular diseases and Hypertension (African-PREDICT).
|
29936324 |
2018 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
ACTH = adrenocorticotropic hormone; AIx@75 = augmentation index corrected for a heart rate of 75 beats per minute; BMI = body mass index; CVD = cardiovascular disease; DBP = diastolic blood pressure; FSH = follicle-stimulating hormone; GH = growth hormone; HT = hypertension; IGF-1 = insulin-like growth factor 1; LH = luteinizing hormone; MBP = mean blood pressure; MRI = magnetic resonance imaging; NFPA = nonfunctioning pituitary adenoma; PP = pulse pressure; PWA = pulse wave analysis; PWV = pulse wave velocity; SBP = systolic blood pressure; TSH = thyroid-stimulating hormone.
|
29975581 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypertension was the major risk factor associated with low IGF1 in RA and stroke.
|
31327319 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
These findings indicate that impaired IGF-IR signalling occurs at early stages, and it may contribute, at least partially, to the development of hypertension and pathological cardiac hypertrophy and to cardiomyocyte apoptosis at later stages in SHR and SPSHR.
|
15996002 |
2005 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor II (IGF-II) and its receptor (IGF-IIR) play vital roles in the development of heart failure during hypertension.
|
29574782 |
2018 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
In IGF-1-deficient mice, the same level of hypertension led to significantly earlier onset and increased incidence and neurological consequences of CMHs, as compared to control mice, as shown by neurological examination, gait analysis, and histological assessment of CMHs in serial brain sections.
|
28295976 |
2017 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Effects of growth hormone and insulin-like growth factor-1 on cardiac hypertrophy of hypertensive patients.
|
17211256 |
2007 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Polymorphism in the promoter region of the insulin-like growth factor I gene is related to carotid intima-media thickness and aortic pulse wave velocity in subjects with hypertension.
|
12791939 |
2003 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Upon multivariate analysis, diabetes was associated with an IGF-1 at diagnosis >2× upper limit of normal, with the persistence of active acromegaly, the presence of hypertension upon the last visit, with the presence of a macroadenoma, and with female sex.
|
29618021 |
2018 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
In a follow-up study, rs13379905 in IGF-1R was associated with hypertension incidence (hazard ratio, HR = 1.24, P = 0.042).
|
29126188 |
2018 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Normotensive subjects had significantly higher IGF1 levels (0.11+/-0.94 SDS) than those with mild (-0.62+/-1.16 SDS, P<0.0001) or severe (-1.01+/-1.07 SDS, P<0.0001) hypertension.
|
18603571 |
2008 |
|
Hypertensive disease
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Furthermore, CAD patients with a minimum of one mutant C allele, T/C or C/C, in IGF-I +1770 gene polymorphism had significantly high blood pressure including systolic blood pressure (SBP; P = 0.025) and diastolic blood pressure (DBP; P = 0.004), compared to CAD patients with T/T homozygotes.
|
23423640 |
2013 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
RGD |
Thus, vascular IGF I gene expression is induced in this model of high-renin hypertension.
|
8418983 |
1993 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We compared clinical features and serum levels of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1), hypertension (HT) and diabetes mellitus (DM) prevalence between the two groups.
|
29113856 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The main data search terms were: Na+/K+-ATPase; estradiol and Na+/K+-ATPase; estradiol, Na+/K+-ATPase and CVS; estradiol, Na+/K+-ATPase and CVD; estradiol, Na+/K+- ATPase and obesity; estradiol, Na+/K+-ATPase and diabetes; estradiol, Na+/K+-ATPase and hypertension; IGF-1; IGF-1 and Na+/K+-ATPase; IGF-1, Na+/K+-ATPase and CVS; IGF-1, Na+/K+-ATPase and CVD; IGF-1, Na+/K+- ATPase and obesity; IGF-1, Na+/K+-ATPase and diabetes; IGF-1, Na+/K+-ATPase and hypertension.
|
28164755 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
This study aimed to investigate the effects of PCA administration on vascular endothelial function, mediated by insulin and insulin-like growth factor-1 (IGF-1), and antioxidant activities in aging hypertension.
|
30934575 |
2019 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
AA = active acromegaly BSA = body surface area CA = biochemically controlled acromegaly CH = concentric hypertrophy CIMT = carotid intima-media thickness DBP = diastolic blood pressure DM = diabetes mellitus ECHO = echocardiography EDV = enddiastolic volume EF = ejection fraction ESV = endsystolic volume GH = growth hormone HC = healthy control HL = hyperlipidemia HT = hypertension IGF-1 = insulin-like growth factor 1 LA = left atrial LAV = left atrial volume LAVI = left atrial volume index LV = left ventricular LVDD = left ventricular diastolic dysfunction LVEF = left ventricular ejection fraction LVH = left ventricular hypertrophy LVMI = left ventricular mass index PWV = pulse-wave velocity RWT = relative wall thickness.
|
28156155 |
2017 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
miR-322-5p targets IGF-1 and is suppressed in the heart of rats with pulmonary hypertension.
|
29511611 |
2018 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension.
|
19502719 |
2009 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
IGF-I, Na and blood pressure were significantly higher in patients with a family history of hypertension than in those without it.
|
8822320 |
1995 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
The vasodilatory effects of insulin-like growth factor-1 (IGF-1) are decreased in hypertension.
|
29556095 |
2018 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
We sought to examine the effects of a 12-week resistance band exercise training program on aging-related hormones including estradiol, growth hormone (GH), insulin-like growth factor-1 (IGF-1), and dehydroepiandrosterone sulfate (DHEA-S), BP, and body composition in postmenopausal women with stage 1 hypertension.
|
31663986 |
2020 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
A custom rat and baboon hypertension gene array to compare experimental models.
|
22228705 |
2012 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
A cross-sectional study compared plasma concentration of cGP, IGF-1 and IGF binding protein (IGFBP)-3 in women with obesity and/or hypertension to normal controls 6-year postpartum using UPLC-MS and ELISA.
|
29921371 |
2018 |