|
Amnesia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results demonstrate altered active IGF1 and IGF1R levels in AD hippocampi, and suggest that boosting brain expression of IGF1 may comprise an approach to prevent neuronal damage and memory loss in AD.
|
31760608 |
2020 |
|
Dizziness
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
S-Ca (HR 1.21 (1.02; 1.44) p = 0.028) also predicted future fractures, whereas PTH, IGF-1, 25(OH) vitamin D, hormone replacement therapy, smoking, degree of physical activity, impaired vision and dizziness did not.
|
31720709 |
2020 |
|
Vertigo
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
S-Ca (HR 1.21 (1.02; 1.44) p = 0.028) also predicted future fractures, whereas PTH, IGF-1, 25(OH) vitamin D, hormone replacement therapy, smoking, degree of physical activity, impaired vision and dizziness did not.
|
31720709 |
2020 |
|
Diabetic Polyneuropathies
|
0.010 |
Biomarker
|
group |
BEFREE |
To study the role of PAPP-A and the IGF system in diabetic polyneuropathy (DPN), we measured immunoreactive (total) concentrations of IGF-I and IGF-II, bioactive IGF by cell-based bioassay, PAPP-A, as well as intact and PAPP-A-cleaved IGFBP-4 in cerebrospinal fluid (CSF) and serum from patients with type 2 diabetes (T2D) with and without DPN.
|
31670029 |
2020 |
|
Memory Loss
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results demonstrate altered active IGF1 and IGF1R levels in AD hippocampi, and suggest that boosting brain expression of IGF1 may comprise an approach to prevent neuronal damage and memory loss in AD.
|
31760608 |
2020 |
|
Obesity cardiomyopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Low IGF-1 plasma levels are correlated to obesity, cardiomyopathy and CPC death, so this work aimed to investigate IGF-1 therapeutic potential on cardiomyopathy and its relationship with the survival, proliferation and differentiation of CPC in Western diet-induced obesity.
|
31753790 |
2020 |
|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The differential expressions of IGF-1R, FOXO3A, and BIM in the benign versus malignant prostate tissues supported a negative association between the FOXO3A/BIM axis and IGF-1R expression in human prostate adenocarcinoma.
|
31312023 |
2019 |
|
Cerebrovascular Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Human studies indicate that low serum levels of free or total IGF-1 contribute to an increased risk of CV and cerebrovascular disease.
|
31692426 |
2019 |
|
Chordoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hub genes FYN, ITGB3, ACTN2, and IGF1, as well as focal adhesion signaling pathway, would be new targets for future treatment options of chordomas.
|
30821656 |
2019 |
|
Craniosynostosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These polygenic mouse models reinforce, in-vivo, that the combination of activation of the IGF1 pathway and disinhibition of the RUNX2 pathway leads to an increased risk of developing craniosynostosis and serves as a model of human SSC.
|
31442251 |
2019 |
|
Diabetes Insipidus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Results Compared with the MEIS, the incidence of growth hormone insulin-like growth factor 1 axis dysfunction (47.03% vs. 57.30%), pituitary-thyroid axis dysfunction (20.00% vs. 50.27%), pituitary-adrenal axis dysfunction (18.38% vs. 43.78%) and diabetes insipidus (26.49% vs. 44.86%) was significantly increased in the ANS status.
|
30694793 |
2019 |
|
Exophthalmos
|
0.010 |
Biomarker
|
disease |
BEFREE |
Emerging therapies target different pathways in the disease and are informed by studies into TED pathogenesis: the last 2 years has, for example, seen the culmination of a two-decade long bench-to-bedside story in which an original focus on the IGF1 receptor has translated into an effective treatment for proptosis in thyroid eye disease.
|
31313753 |
2019 |
|
Gangrene
|
0.010 |
Biomarker
|
disease |
BEFREE |
In retrospect, there were several signs probably indicating the development of the gangrene: (i) a decline in bioelectrical phase angle; (ii) an accelerated weight and fat-free mass loss starting in the third week of radiotherapy; (iii) an increase in C-reactive protein (CRP) and concurrent drop in high-density lipoprotein (HDL) cholesterol and insulin-like growth factor(IGF)-1 concentrations; and (iv) the occurrence of a sharp pain in the perianal region reported in the fifth week of radiotherapy.
|
30470845 |
2019 |
|
Lymphoid leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Long non-coding RNA deleted in lymphocytic leukaemia 1 promotes hepatocellular carcinoma progression by sponging miR-133a to regulate IGF-1R expression.
|
31207081 |
2019 |
|
Globoid cell leukodystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using authentic cellular and animal models for Krabbe disease, we provide a mechanism explaining the inactivation of lipid raft (LR)-associated IGF-1-PI3K-Akt-mTORC2, a pathway of crucial importance for neuronal function and survival.
|
31036560 |
2019 |
|
Neural Tube Defects
|
0.010 |
Biomarker
|
group |
BEFREE |
The frequency of NTD was found 69%.Patients with NTD were older (p = 0.05), with higher baseline IGF-1%ULN (upper limit of normal) (p = 0.01).
|
30430336 |
2019 |
|
Obsessive-Compulsive Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
We studied TALLYHO/JngJ (TH) mice, a model of type 2 diabetes mellitus, to (1) assess compulsive and anxious behaviors, (2) determine neuro-metabolite levels by 1 H magnetic resonance spectroscopy (MRS) and brain structural connectivity by diffusion tensor imaging (DTI), and (3) investigate plasma and brain protein levels for molecules previously associated with OCD (insulin, Igf1, Kcnq1, and Bdnf) in these subjects.
|
31515486 |
2019 |
|
Otosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Maternal serum concentrations of GH-V and IGF-1 were altered in pregnancy complicated by otosclerosis, suggesting that the GH-IGF axis may contribute to the development of this condition during pregnancy.
|
31148391 |
2019 |
|
Parathyroid Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Currently, the clinical importance TBS was verified in terms of disorders of the growth hormone/insulin-like growth factor 1 (GH/IGF-I) axis, glucocorticoid excess, thyroid and parathyroid disease, as well as in diabetes mellitus type 1 and 2.
|
31489959 |
2019 |
|
Pregnancy in Diabetics
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In this report we asked whether changes in GLUT1 expression and glucose transport activity in diabetic pregnancies were associated with alterations in the fetal IGF axis.
|
31175930 |
2019 |
|
Kidney Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further studies showed that this failure of PTH to maintain blood 1,25(OH)<sub>2</sub>D levels was associated with decreased blood levels of IGF-1, increased blood levels of FGF-23, and kidney failure.
|
31791247 |
2019 |
|
Rickets
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Although limited by some bias, from the analysis of the studies presented in the scientific literature, it is possible to hypothesize a greater frequency of hypovitaminosis D in the subjects affected by GHD, a reduced possibility of its correction with only substitution treatment with recombinant growth hormone (rGH) and an improvement of IGF-1 levels after supplementation treatment with vitamin D.
|
30885216 |
2019 |
|
Skin Ulcer
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Therefore, it is concluded that an appropriate concentration of IGF-1 can significantly promote the healing of skin ulcers in diabetic rats.
|
31162036 |
2019 |
|
Sleep disturbances
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Then, we analyzed associations of IGF-1 variants with neuropsychiatric symptoms after mTBI, including anxiety, depression, dizziness, and sleep disturbances.
|
31787098 |
2019 |
|
West Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
We examined cerebrospinal fluid (CSF) concentrations for neurotrophins, nerve growth factor (β-NGF) and insulin-like growth factor (IGF-1) in children with infantile spasms between 1997 and 2010.
|
30503720 |
2019 |