|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
While amyloid fibrils in SPs are composed of beta-amyloid (A beta), NFTs and SPs contain similar associated components such as ubiquitin, alpha 1-antichymotrypsin (ACT), apolipoprotein E (ApoE), heparan sulfate proteoglycans (HSPGs), and aluminum salts.
|
7525898 |
1994 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Regression analyses found that increased ISD was associated with increased NFT pathology (β= 10.93, SE = 3.82, p = 0.004), but not with DPs (β= 1.33, SE = 8.85, p = 0.88) or NPs (β= 14.64, SE = 8.45, p = 0.08) after adjusting for age at death, gender, education, APOE ɛ4 status, and clinical diagnosis.
|
28453479 |
2017 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The three cases with apolipoprotein E ε4 haplotype showed scattered β-amyloid plaques in the overlying gray matter, but not the two cases with apolipoprotein E ε3/3 genotype.
|
27885490 |
2017 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
LB stage V had higher stages of neurofibrillary tangle and senile plaque involvement and also had a higher frequency of apolipoprotein E epsilon4.
|
15290899 |
2004 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In demented patients, the GFAP expression, counts of AD lesions, senile/neuritic plaques (SP/NP) and neurofibrillary tangles (NFT) were higher in patients carrying the apolipoprotein E (ApoE) epsilon4 allele compared to those without the ApoE epsilon4 allele.
|
10364641 |
1999 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In age- and APOE-adjusted analyses, the minor G-allele of rs2774276, previously linked to elevated cholesterol, associated with late-stage burnt out SP among women and early non-neuritic SP among men.
|
22390463 |
2012 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
VF F(2)-IsoP concentrations were not related to density of neuritic plaques or neurofibrillary tangles in seven brain regions, or to the number of epsilon4 alleles of the apolipoprotein E gene (APOE).
|
10487843 |
1999 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The anti apoE4 antibody visualized senile plaques, neurofibrillary tangles and reactive astrocytes, as well as serum in the blood vessels and vascular smooth muscle cells in the cases of epsilon4.
|
15129156 |
2004 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
When a model of multiple linear regression was used to compare the relative influence of APOE genotype, sex, disease duration, age at death, diffuse and neuritic plaques as well as neurofibrillary tangles on microglial activation, only APOE genotype was found to have a significant effect.
|
9669695 |
1998 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (ApoE), a protein manufactured and distributed throughout the body, has shown specificity of binding to the beta A4 peptide, the primary component in the senile plaques of AD.
|
9929677 |
1998 |
|
Senile Plaques
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Differential pattern of beta-amyloid, amyloid precursor protein and apolipoprotein E expression in cortical senile plaques.
|
9292695 |
1997 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied whether ApoE and -219 GT (ApoE promoter) polymorphism modulates neurofibrillary tangle (NFT) and senile plaque (SP) development in aging among 190 non-institutionalized individuals (mean age 79.5 years).
|
11182472 |
2001 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The PS-1 and apolipoprotein E (ApoE) genotypes, were examined, together with the densities of the senile plaques, senile plaques with dystrophic neurites, and neurofibrillary tangles in the brains from 36 postmortem confirmed patients with sporadic Alzheimer's disease and 86 non-demented subjects.
|
9576554 |
1998 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Recent studies on the effect of murine and human apoE in APP transgenic mice provide direct evidence that apoE is critically involved in the in vivo converstion of Abeta into forms which contain high 5-sheet content and associated cellular toxicity (neuritic plaques and CAA).
|
11816788 |
2001 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The patients were apoE genotyped and the density of β-amyloid senile plaques, neuritic plaques and neurofibrillary tangles was estimated in the cortex and hippocampus.
|
25898889 |
2015 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Expression of apoE3 and apoE4 in APP(V717F) TG, apoE(-/-) mice resulted in fibrillar Abeta deposits and neuritic plaques by 15 months of age and substantially (>10-fold) more fibrillar deposits were observed in apoE4-expressing APP(V717F) TG mice.
|
10694577 |
2000 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The data suggest a relationship between heart disease, APOE4 genotype and the presence of SP regardless of cognitive status.
|
8791246 |
1996 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In addition, in a subgroup of patients, individual differences were related to apolipoprotein E (ApoE) genotype, the presence and severity of SP in the frontal and occipital cortex being significantly increased in patients expressing apolipoprotein (Apo)E allele epsilon4.
|
10935434 |
2000 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
The discrepancy between ApoE and A beta deposition may reflect different stages of amyloidogenesis in SP.
|
9098525 |
1997 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Cholesterol and LDL relate to neuritic plaques and to APOE4 presence but not to neurofibrillary tangles.
|
21244352 |
2011 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
APOE [Latin Small Letter Open E]4 is a major risk factor for late-onset Alzheimer disease, a progressive neurodegenerative disorder that affects memory, thinking, behavior, and emotion as a result of the excessive buildup and decreased clearance of β-amyloid proteins resulting in the appearance of neuritic plaques and neurofibrillary tangles.
|
23715207 |
2015 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
Several lines of evidence implicate apolipoprotein E (apoE) and its receptor--the low density lipoprotein receptor related protein (LRP)--in Alzheimer's disease (AD) pathogenesis, including increased amyloid deposition in human AD brains of people containing the apoE epsilon 4 allele, presence of apoE and LRP in amyloid plaques, and in vitro uptake of amyloid precursor protein (APP) and amyloid beta protein (A beta) by LRP.
|
11193147 |
2000 |
|
Senile Plaques
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Histological grading of brain sections stained with the modified Bielschowsky stain according to the criteria of CERAD; number (burden) of neuritic plaques; apolipoprotein E genotype (APOE).
|
8692066 |
1996 |
|
Senile Plaques
|
0.200 |
Biomarker
|
disease |
BEFREE |
In addition, some isoform-specific interactions of apolipoprotein E have been demonstrated with the defining pathological lesions of Alzheimer's disease, the neurofibrillary tangle and neuritic plaque.
|
8833436 |
1996 |