Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APOE ε4 allele is an established risk factor for Alzheimer's disease and hypercholesterolemia.
|
31677348 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, the effects of diet-induced hypercholesterolemia on cardiac function and remodeling were investigated up to eight weeks after myocardial ischemia-reperfusion (MI-R) injury which was induced in either normocholesterolemic (NC-MI) or hypercholesterolemic (HC-MI) APOE*3-Leiden mice.
|
31199833 |
2019 |
Hypercholesterolemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Gestational hypercholesterolemia alters fetal hepatic lipid metabolism and microRNA expression in Apo-E-deficient mice.
|
31453710 |
2019 |
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
APOE genotypes were not associated with hypercholesterolemia.
|
30457419 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
To characterize their effect on atherogenesis, APOE*3Leiden.CETP mice were fed a high cholesterol/high fat diet (WTD) or normal chow (NC) for 18 weeks.
|
31366894 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Furthermore, in an ex vivo atherosclerotic plaque model of apolipoprotein E knockout (KO) (apoE<sup>-/-</sup>) mice induced by high cholesterol, the NPs selectively accumulated at the sites of SR-A expressed on the activated macrophages of the aortic region.
|
30785263 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In parallel, apolipoprotein E-deficient (ApoE<sup>-/-</sup>) mice received a high-fat, high-cholesterol diet to induce atherosclerosis for 8 weeks, after which ApoE<sup>-/-</sup> mice received 300 <i>μ</i>g/kg of Lir daily or vehicle control for a further 4 weeks to investigate the attenuation of atherosclerosis.
|
31270216 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice were fed a high-fat (60%) high-cholesterol (1%) diet (HFHCD) for 2 wk, followed by 6-wk 1% CLA 80:20 supplementation to investigate disease progression.
|
31284764 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
To test our clinical hypothesis, we designed two male animal models: Exogenous hypercholesterolaemia induced by a high‑cholesterol diet (HCD) and endogenous hypercholesterolaemia induced by apolipoprotein E (ApoE) knockout.
|
30957178 |
2019 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K<sup>+</sup> Channels.
|
29502106 |
2018 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE<sup>-/-</sup>) mice compared with age-matched wild-type C57BL/6 (WT) mice.
|
30185234 |
2018 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Results from WT and apoE KO bone marrow chimera suggest that apoE from cells of hematopoietic origin has immunomodulatory functions, regardless of the onset of hypercholesterolemia.
|
30082772 |
2018 |
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We recruited 49 nonfamilial hypercholesterolemia genetic hypercholesterolemia families (294 participants) and calculated cholesterol gene scores, derived from single nucleotide variants in SORT1, APOB, ABCG8, APOE and LDLR and lipoprotein(a) plasma concentration.
|
28919240 |
2018 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice.
|
29936931 |
2018 |
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, LHRD treatment significantly diminished total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in apolipoprotein E gene-knockout (ApoE<sup>-/-</sup>) mice fed with high fat and high cholesterol diet (western diet).
|
30402125 |
2018 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Thymoquinone reduces cardiac damage caused by hypercholesterolemia in apolipoprotein E-deficient mice.
|
30049280 |
2018 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results of the present study suggested that Ex4 may exert cardioprotective effects by reversing high‑cholesterol diet‑induced endothelial dysfunction in APOE‑KO mice.
|
30085331 |
2018 |
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to investigate the effects of HS and GP tea consumption on anthropometric data, fasting blood glucose (FBG), and lipid concentrations in hypercholesterolemia subjects with different genotypes of the APOE and CETP TaqIB polymorphisms.
|
28244718 |
2017 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E-deficient mice and the underlying mechanism.
|
28935756 |
2017 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We maintained apolipoprotein E-deficient mice on a high cholesterol diet and induced myocardial infarction by transient ligation at 4 weeks.
|
28397162 |
2017 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
We found that JAB1 was present in CD68-immunoreactive (-ir) MΦ in atherosclerotic plaques of apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice after a high cholesterol/fat diet.
|
28173800 |
2017 |
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
This study shows the relevance of polymorphisms in APOB (odds ratio (OR), 1.17; 95% confidence interval (95% CI), 0.74-1.85), APOC3 (OR, 1.33; 95% CI, 0.82-2.17) and APOE (OR, 1.75; 95% CI, 1.09-2.80), as genetic risk markers for hypercholesterolemia; polymorphisms in ACE (OR, 1.68; 95% CI, 0.32-8.77) and AGT (OR, 1.74; 95% CI, 0.97-3.14) for hypertension; and in APOE*3/*4 (OR, 2.06; 95% CI, 1.70-2.51) and APOE*4/*4 (OR, 3.08; 95% CI, 1.85-5.12) as unambiguous markers of dementia.
|
29081697 |
2017 |
Hypercholesterolemia
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Demographic and vascular risk factors were measured at baseline (obesity, smoking, diabetes, prehypertension, hypertension, and hypercholesterolemia) as well as presence of the APOE ε4 genotype.
|
28783817 |
2017 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice.
|
28205167 |
2017 |
Hypercholesterolemia
|
0.700 |
Biomarker
|
disease |
BEFREE |
APOE-e4 associated with a higher likelihood of hypercholesterolemia and overall illness index scores (ps < .05).
|
27486898 |
2016 |