APOE, apolipoprotein E, 348

N. diseases: 1049; N. variants: 62
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE APOE ε4 allele is an established risk factor for Alzheimer's disease and hypercholesterolemia. 31677348 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Therefore, the effects of diet-induced hypercholesterolemia on cardiac function and remodeling were investigated up to eight weeks after myocardial ischemia-reperfusion (MI-R) injury which was induced in either normocholesterolemic (NC-MI) or hypercholesterolemic (HC-MI) APOE*3-Leiden mice. 31199833 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 AlteredExpression disease BEFREE Gestational hypercholesterolemia alters fetal hepatic lipid metabolism and microRNA expression in Apo-E-deficient mice. 31453710 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE APOE genotypes were not associated with hypercholesterolemia. 30457419 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE To characterize their effect on atherogenesis, APOE*3Leiden.CETP mice were fed a high cholesterol/high fat diet (WTD) or normal chow (NC) for 18 weeks. 31366894 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Furthermore, in an ex vivo atherosclerotic plaque model of apolipoprotein E knockout (KO) (apoE<sup>-/-</sup>) mice induced by high cholesterol, the NPs selectively accumulated at the sites of SR-A expressed on the activated macrophages of the aortic region. 30785263 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE In parallel, apolipoprotein E-deficient (ApoE<sup>-/-</sup>) mice received a high-fat, high-cholesterol diet to induce atherosclerosis for 8 weeks, after which ApoE<sup>-/-</sup> mice received 300 <i>μ</i>g/kg of Lir daily or vehicle control for a further 4 weeks to investigate the attenuation of atherosclerosis. 31270216 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice were fed a high-fat (60%) high-cholesterol (1%) diet (HFHCD) for 2 wk, followed by 6-wk 1% CLA 80:20 supplementation to investigate disease progression. 31284764 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE To test our clinical hypothesis, we designed two male animal models: Exogenous hypercholesterolaemia induced by a high‑cholesterol diet (HCD) and endogenous hypercholesterolaemia induced by apolipoprotein E (ApoE) knockout. 30957178 2019
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Hypercholesterolemia-Induced Loss of Flow-Induced Vasodilation and Lesion Formation in Apolipoprotein E-Deficient Mice Critically Depend on Inwardly Rectifying K<sup>+</sup> Channels. 29502106 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE In this study, we evaluated the influence of aging and hypercholesterolemia on serum pro-inflammatory cytokines, oxidative stress, DNA damage and apoptosis in monocytes from apolipoprotein E-deficient (apoE<sup>-/-</sup>) mice compared with age-matched wild-type C57BL/6 (WT) mice. 30185234 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Results from WT and apoE KO bone marrow chimera suggest that apoE from cells of hematopoietic origin has immunomodulatory functions, regardless of the onset of hypercholesterolemia. 30082772 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE We recruited 49 nonfamilial hypercholesterolemia genetic hypercholesterolemia families (294 participants) and calculated cholesterol gene scores, derived from single nucleotide variants in SORT1, APOB, ABCG8, APOE and LDLR and lipoprotein(a) plasma concentration. 28919240 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE LJ-1888, a selective antagonist for the A3 adenosine receptor, ameliorates the development of atherosclerosis and hypercholesterolemia in apolipoprotein E knock-out mice. 29936931 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE In this study, LHRD treatment significantly diminished total cholesterol (TC), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-C) levels in apolipoprotein E gene-knockout (ApoE<sup>-/-</sup>) mice fed with high fat and high cholesterol diet (western diet). 30402125 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Thymoquinone reduces cardiac damage caused by hypercholesterolemia in apolipoprotein E-deficient mice. 30049280 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE The results of the present study suggested that Ex4 may exert cardioprotective effects by reversing high‑cholesterol diet‑induced endothelial dysfunction in APOE‑KO mice. 30085331 2018
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE The aim of this study was to investigate the effects of HS and GP tea consumption on anthropometric data, fasting blood glucose (FBG), and lipid concentrations in hypercholesterolemia subjects with different genotypes of the APOE and CETP TaqIB polymorphisms. 28244718 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE We investigated the effect of perinatal hypercholesterolemia on the atherosclerosis development in the offspring of apolipoprotein E-deficient mice and the underlying mechanism. 28935756 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE We maintained apolipoprotein E-deficient mice on a high cholesterol diet and induced myocardial infarction by transient ligation at 4 weeks. 28397162 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE We found that JAB1 was present in CD68-immunoreactive (-ir) MΦ in atherosclerotic plaques of apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice after a high cholesterol/fat diet. 28173800 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE This study shows the relevance of polymorphisms in APOB (odds ratio (OR), 1.17; 95% confidence interval (95% CI), 0.74-1.85), APOC3 (OR, 1.33; 95% CI, 0.82-2.17) and APOE (OR, 1.75; 95% CI, 1.09-2.80), as genetic risk markers for hypercholesterolemia; polymorphisms in ACE (OR, 1.68; 95% CI, 0.32-8.77) and AGT (OR, 1.74; 95% CI, 0.97-3.14) for hypertension; and in APOE*3/*4 (OR, 2.06; 95% CI, 1.70-2.51) and APOE*4/*4 (OR, 3.08; 95% CI, 1.85-5.12) as unambiguous markers of dementia. 29081697 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 GeneticVariation disease BEFREE Demographic and vascular risk factors were measured at baseline (obesity, smoking, diabetes, prehypertension, hypertension, and hypercholesterolemia) as well as presence of the APOE ε4 genotype. 28783817 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR -/-) mice and apolipoprotein E deficient (ApoE) -/- mice. 28205167 2017
CUI: C0020443
Disease: Hypercholesterolemia
Hypercholesterolemia
0.700 Biomarker disease BEFREE APOE-e4 associated with a higher likelihood of hypercholesterolemia and overall illness index scores (ps < .05). 27486898 2016