Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-deficient (Apoe<sup>-/-</sup>) mice develop significant hyperlipidemia and hyperglycemia on a Western diet.
|
31821957 |
2020 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
APOE∗3-Leiden (E3L) mice are a well-established model for diet-induced hyperlipidemia and atherosclerosis, and glucokinase<sup>+/-</sup> (GK<sup>+/-</sup>) mice are a translatable disease model for glucose control in type 2 diabetes.
|
30949516 |
2019 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we combined bilateral common carotid artery stenosis (BCAS) with a hyperlipidaemia model in order to develop a mouse model of SVaD; 10- to 12-week-old apolipoprotein E (ApoE)-deficient or wild-type C57BL/6J mice were subjected to sham operation or chronic cerebral hypoperfusion with BCAS using micro-coils.
|
29053032 |
2019 |
Hyperlipidemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To investigate the pathological changes of the meibomian gland (MG) and ocular surface in Apolipoprotein E knockout (ApoE<sup>-/-</sup>) mice and to investigate the association of meibomian gland dysfunction (MGD) with hyperlipidemia.
|
31201956 |
2019 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
RGD |
Deficiency of either Ldlr or Apoe genes induced hyperlipidemia, which promoted endothelial inflammation and led to typical atherosclerosis in rats on normal or Western diets.
|
29459263 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Approach and Results- We designed a model system that allows for the conversion to a state of acute hyperlipidemia in adult life, so that the consequences of such a transition could be observed, through conditionally deleting APOE (apolipoprotein E) in the adult mouse.
|
29880490 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, ApoE plays crucial roles in preserving bone mass, suggesting that targeting ApoE and its isoforms as a promising treatment candidate of both osteoporosis and hyperlipidemia.
|
29906458 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Coenzyme Q10 protects against hyperlipidemia-induced cardiac damage in apolipoprotein E-deficient mice.
|
30526612 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We further obtained NOD mice deficient in both LDLR and ApoE, and assessed the severity of atherosclerosis and immune response to hyperlipidemia in comparison to ApoE-deficient C57BL/6 mice.
|
30305306 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of present study was to investigate the anti-atherosclerotic effects of LPPC on atherosclerosis and hyperlipidemia in apolipoprotein E knockout (ApoE KO) mice fed a high fat diet (HFD, 21% fat, 0.15% cholesterol) for 24 weeks.
|
29793326 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Deficiency of either Ldlr or Apoe genes induced hyperlipidemia, which promoted endothelial inflammation and led to typical atherosclerosis in rats on normal or Western diets.
|
29459263 |
2018 |
Hyperlipidemia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
At Bonferroni-adjusted significance thresholds, levels of apolipoprotein E isoforms were associated with hyperlipidemia, and circulating C-type lectin domain family 1 member B and platelet-derived growth factor receptor-β predicted subclinical atherosclerosis.
|
30571344 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
A fasting lipid panel showed mild hyperlipidemia and elevated serum apoE (5.6 mg/dL).
|
29398675 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (apoE) knock-out (KO) mice are frequently used for the study of hyperlipidemia and atherosclerosis.
|
30021609 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this regard, we used the Apolipoprotein E-deficient (ApoE<sup>-/-</sup>) mouse model, an established model of hyperlipidaemia and atherosclerosis, that does not become obese when subjected to a high-fat diet, to determine the impact of Western-type diet (WD) and ApoE deficiency on skeletal muscle morphological, metabolic and biochemical properties.
|
30342191 |
2018 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the effects of hyperlipidemia on histological changes and apoptosis in submandibular glands using apolipoprotein E (apoE)-deficient rats.
|
28528308 |
2017 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo, these IRE1 inhibitors led to a significant decrease in hyperlipidemia-induced IL-1β and IL-18 production, lowered T-helper type-1 immune responses, and reduced atherosclerotic plaque size without altering the plasma lipid profiles in apolipoprotein E-deficient mice.
|
28137856 |
2017 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
APOE-knockout rabbits have recently been shown to generate hyperlipidemia with increased levels of cholesterol and triglycerides that mimic the symptoms of atherosclerosis in humans.
|
29099857 |
2017 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The strongest associations for lipid levels change were detected at LPL, TRIB1, APOA1-C3-A4-A5, LIPC, CETP, and LDLR (P range from 4.84×10(-4) to 4.62×10(-18)), whereas LPL, TRIB1, ABCA1, APOA1-C3-A4-A5, CETP, and APOE displayed significant strongest associations for incident hyperlipidemia (P range from 1.20×10(-3) to 4.67×10(-16)).
|
26582766 |
2016 |
Hyperlipidemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The p.Leu167del mutation in the APOE gene has been associated with hyperlipidemia.
|
27014949 |
2016 |
Hyperlipidemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The polymorphism in apolipoprotein E (ApoE) has been linked to the development of diabetic nephropathy (DN) in association with hyperlipidemia.
|
26662731 |
2016 |
Hyperlipidemia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E-deficient (apoE(-/-)) mice chronically treated with DEHP for 4 weeks showed exacerbated hyperlipidemia, systemic inflammation, and atherosclerosis.
|
25270622 |
2016 |
Hyperlipidemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Primary genetic investigation of a hyperlipidemia model: molecular characteristics and variants of the apolipoprotein E gene in Mongolian gerbil.
|
25006576 |
2014 |
Hyperlipidemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Association of apolipoprotein E gene polymorphism with end-stage renal disease and hyperlipidemia in patients on long-term hemodialysis.
|
25155022 |
2014 |
Hyperlipidemia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study evaluated associations of APOE and APOA5 genotype with baseline lipid levels and response to rosuvastatin in Chinese patients with hyperlipidemia.
|
23312054 |
2013 |