Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course.
|
29532745 |
2019 |
Multiple Sclerosis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maintaining of cholesterol homeostasis in the rat spinal cord: 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) during the course of disease.
|
28578430 |
2017 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite pleiotropic immunomodulatory effects of apolipoprotein E (apoE) in vitro, its effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) are still controversial.
|
26669675 |
2015 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Additionally, a class of compounds currently in phase III clinical trials for multiple sclerosis and rheumatologic conditions, the quinoline-3-carboxamides, reduce atherosclerotic plaque burden and complexity in transgenic S100A12 apolipoprotein E null mice, but have not been tested with regards to human atherosclerosis.
|
26515415 |
2015 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility.
|
23726763 |
2013 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Given the large sample size of our analyses, it is unlikely that the two APOE missense SNPs studied here exert any relevant effects on MS susceptibility.
|
22972946 |
2012 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, the present meta-analysis provides evidence that ApoE ε2 mutation is associated with MS risk.
|
22982410 |
2012 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It seems that individuals carrying APOE-ε4 allele and/or APOE-ε3ε4 genotype develop MS two times more than non-carriers.
|
22698480 |
2012 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Subgroup analysis revealed that APOE ε4, 2 alleles were not associated with an increased risk of MS in Caucasian population (OR(c-ε4)=0.924, 95% CI=0.819-1.041; OR(c-ε2)=1.127, 95% CI=0.955-1.331).
|
21679970 |
2011 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
CONCLUSION - No association between cognitive impairment and ApoE-4 or clinical markers was detected in our MS patients.
|
21208197 |
2011 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Influence of APOE gene polymorphisms on interferon-beta treatment response in multiple sclerosis.
|
21163235 |
2011 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of the present study was to determine whether the ε4 allele of APOE is associated with more extensive brain pathology in MS using structural and diffusion tensor MRI.
|
21723395 |
2011 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Results for the e4/e2 alleles of the ApoE gene as markers of susceptibility, clinical and radiological progression, and cognitive deterioration in patients with multiple sclerosis (MS) are contradictory.
|
21325856 |
2011 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis.
|
21772670 |
2011 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common APOE genotype in MS patients was epsilon3/epsilon3 (82.0%).
|
22165672 |
2011 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E ε4-positive multiple sclerosis patients develop more gray-matter and whole-brain atrophy: a 15-year disease history model based on a 4-year longitudinal study.
|
21324265 |
2010 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
APOE epsilon4 and cognitive dysfunction in multiple sclerosis: a review.
|
20463109 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS.
|
20479360 |
2010 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results.
|
19786693 |
2009 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recent clinical studies have identified an association between APOE 4 and cognitive deficits in patients with multiple sclerosis.
|
19422789 |
2009 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The role of APOE-epsilon4 as a possible biomarker in multiple sclerosis is still questionable.
|
19965518 |
2009 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability.
|
19473356 |
2009 |
Multiple Sclerosis
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To evaluate ApoE alleles in relation to symptoms of depression in a cohort of patients with MS participating in the Sonya Slifka Longitudinal Multiple Sclerosis Study (Slifka Study).
|
19244396 |
2009 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the modest effects do not justify APOE genotyping of patients with MS in clinical practice.
|
17460153 |
2008 |
Multiple Sclerosis
|
0.400 |
Biomarker
|
disease |
BEFREE |
So, our data do not support a role for APOE in MS severity, in spite of the seeming influence shown using other measures such as PI.
|
17883422 |
2008 |