APOE, apolipoprotein E, 348

N. diseases: 1049; N. variants: 62
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE The aim of this study was to assess the impact of APOE and HLA polymorphisms as well as smoking and body mass index (BMI) in the very early MS course. 29532745 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 AlteredExpression disease BEFREE Using an experimental autoimmune encephalomyelitis (EAE) model of MS we revealed specific changes in the mRNA and protein expression of key molecules involved in the maintaining of cholesterol homeostasis in the rat spinal cord: 3-hydroxy-3-methylglutaryl-coenzyme-A reductase (HMGCR), apolipoprotein E (ApoE) and cholesterol 24-hydroxylase (CYP46A1) during the course of disease. 28578430 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Despite pleiotropic immunomodulatory effects of apolipoprotein E (apoE) in vitro, its effects on the clinical course of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis (MS) are still controversial. 26669675 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Additionally, a class of compounds currently in phase III clinical trials for multiple sclerosis and rheumatologic conditions, the quinoline-3-carboxamides, reduce atherosclerotic plaque burden and complexity in transgenic S100A12 apolipoprotein E null mice, but have not been tested with regards to human atherosclerosis. 26515415 2015
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Our results indicate that in this population, SNPs in IL7R, TYK2, IRF5 and APOE have modifying effects on MS susceptibility. 23726763 2013
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Given the large sample size of our analyses, it is unlikely that the two APOE missense SNPs studied here exert any relevant effects on MS susceptibility. 22972946 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE In summary, the present meta-analysis provides evidence that ApoE ε2 mutation is associated with MS risk. 22982410 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE It seems that individuals carrying APOE-ε4 allele and/or APOE-ε3ε4 genotype develop MS two times more than non-carriers. 22698480 2012
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Subgroup analysis revealed that APOE ε4, 2 alleles were not associated with an increased risk of MS in Caucasian population (OR(c-ε4)=0.924, 95% CI=0.819-1.041; OR(c-ε2)=1.127, 95% CI=0.955-1.331). 21679970 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE CONCLUSION - No association between cognitive impairment and ApoE-4 or clinical markers was detected in our MS patients. 21208197 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Influence of APOE gene polymorphisms on interferon-beta treatment response in multiple sclerosis. 21163235 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE The purpose of the present study was to determine whether the ε4 allele of APOE is associated with more extensive brain pathology in MS using structural and diffusion tensor MRI. 21723395 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Results for the e4/e2 alleles of the ApoE gene as markers of susceptibility, clinical and radiological progression, and cognitive deterioration in patients with multiple sclerosis (MS) are contradictory. 21325856 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis. 21772670 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE The most common APOE genotype in MS patients was epsilon3/epsilon3 (82.0%). 22165672 2011
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Apolipoprotein E ε4-positive multiple sclerosis patients develop more gray-matter and whole-brain atrophy: a 15-year disease history model based on a 4-year longitudinal study. 21324265 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE APOE epsilon4 and cognitive dysfunction in multiple sclerosis: a review. 20463109 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE The purpose of this study was to determine whether the epsilon4 allele of APOE is associated with cognitive deficits in patients with MS. 20479360 2010
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE The influence of APOE allelic heterogeneity on multiple sclerosis (MS) disease severity has been reported in multiple datasets with conflicting results. 19786693 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE Recent clinical studies have identified an association between APOE 4 and cognitive deficits in patients with multiple sclerosis. 19422789 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE The role of APOE-epsilon4 as a possible biomarker in multiple sclerosis is still questionable. 19965518 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE Our data suggest that in women with MS carrying the ApoE E4 isoform, cigarette smoking may have a protective influence on disease progression and accumulation of disability. 19473356 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 GeneticVariation disease BEFREE To evaluate ApoE alleles in relation to symptoms of depression in a cohort of patients with MS participating in the Sonya Slifka Longitudinal Multiple Sclerosis Study (Slifka Study). 19244396 2009
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE However, the modest effects do not justify APOE genotyping of patients with MS in clinical practice. 17460153 2008
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis
0.400 Biomarker disease BEFREE So, our data do not support a role for APOE in MS severity, in spite of the seeming influence shown using other measures such as PI. 17883422 2008