Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to evaluate cerebrospinal fluid (CSF) concentrations of apolipoprotein E and α-synuclein in patients with these two diseases so that they may serve as biomarkers to monitor therapy in Parkinson's disease and schizophrenia.
|
31410011 |
2019 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Taken together, the meta-analysis and longitudinal analysis implicate APOE-ε4 as an age-related risk factor for worsening hallucinations and delusions, and suggest APOE-ε4 may play an age-mediated pathophysiological role in schizophrenia.
|
30584027 |
2019 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In the dlPFC, individuals with SZ had higher expression, relative to HCs, of APOE.
|
29680575 |
2018 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ACE D and APOE ε4 carrier status, independent of medication use, was associated with lower verbal memory scores in patients with schizophrenia who had relatively lower CR, as identified by formal education.
|
28605058 |
2017 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we explored the correlations between the APOE genotype and glucose/lipid metabolism indicators and abnormalities in hospitalized patients 60 years or older with schizophrenia with a history of long-term antipsychotics use.
|
29233125 |
2017 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This method was applied to a genetic association analysis of APOE and schizophrenia consisting of 711 patients with schizophrenia and 665 control subjects from Taiwan.
|
27078154 |
2016 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In each case, a single gene is represented in a plurality of epistatic interactions, apolipoprotein E (APOE) for AD and catechol-O-methyltransferase for schizophrenia.
|
25403528 |
2015 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
To explore the role of these 2 molecules, we quantified cholesterol and apoE levels in prefrontal grey and white matter in patients with schizophrenia, bipolar disorder and healthy controls.
|
20964956 |
2011 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review will summarise the current understanding of the involvement of APOE and its receptors in the symptomatology and pathology of schizophrenia and mood disorders and the implications of this involvement for drug treatment.
|
21196212 |
2011 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
APOE genotypes have no major influence on risk of schizophrenia, treatment and response to conventional antipsychotics, and age of onset in schizophrenia.
|
20583903 |
2010 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results provide evidence that the APOE gene may play a significant role in the etiology of schizophrenia in the Mexican population.
|
19996253 |
2009 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
|
19165527 |
2009 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
APOE genetic polymorphism potentially influences susceptibility to schizophrenia and may be associated with aspects of its phenotypic expression, particularly gender, age of onset and family history of psychotic illness.
|
19752580 |
2009 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
CTD_human |
Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
|
18583979 |
2008 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Analyses of variants located in estrogen metabolism genes (ESR1, ESR2, COMT and APOE) and schizophrenia.
|
18164902 |
2008 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The APOE genotypes of these patients were compared to previously published genotypes of controls and with previously published studies of APOE genotypes in patients with schizophrenia.
|
16261623 |
2006 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
After allowing for sensitivity analysis of the studies and assessment of publication bias, we conclude that the epsilon4 allele of Apolipoprotein E does not play a major role in risk of schizophrenia in Caucasian populations.
|
16567081 |
2006 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The authors concluded that olfactory deficits in schizophrenia do not appear to be mediated by the ApoE allele.
|
16720801 |
2006 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
LHGDN |
Differential changes in apolipoprotein E in schizophrenia and bipolar I disorder.
|
15820227 |
2005 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Apolipoprotein E polymorphism is associated with age of onset in schizophrenia.
|
15221639 |
2004 |
Schizophrenia
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
No relationship between APOE polymorphism and risk for schizophrenia was found.
|
15221639 |
2004 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
RGD |
The genetic association database.
|
15118671 |
2004 |
Schizophrenia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We suggest that APOE may operate as an additional risk factor for schizophrenia in individuals subjected to fetal and/or early postnatal malnutrition.
|
12837518 |
2003 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia.
|
13129656 |
2003 |
Schizophrenia
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These data support the hypothesis that increased levels of apoE may be associated with the pathology of schizophrenia and that antipsychotic drugs decrease apoE levels as part of their therapeutic actions.
|
13129656 |
2003 |