Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest a protective role for APOE-ε2 allele to wet AMD in the Northern Spanish population.
|
31654486 |
2019 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our data demonstrated that ApoE 4/2 genotype was less frequently observed in old patients (65 years and more) with exudative AMD compared to old healthy controls.
|
29851526 |
2018 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The APOE isoform ε2 is a risk factor for age-related macular degeneration; nevertheless, APOE absence in humans and mice does not significantly affect the retina.
|
30333155 |
2018 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Cholesterol efflux genes (APOE and ABCA1) were identified as risk factors for AMD, although how cholesterol efflux influences accumulation of this lipid in sub-RPE deposits remains elusive.
|
28973423 |
2017 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (ApoE) and complement activation products such as membrane attack complex (MAC) are present in eyes of individuals with AMD.
|
28632844 |
2017 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Stratification analysis by ethnicity revealed that the ApoE ε4 carriers was associated with neovascular AMD in both Caucasians (OR = 0.62, 95% CI = 0.47-0.83) and East Asians (OR = 0.68, 95% CI = 0.58-0.79).
|
28889998 |
2017 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The current study was conducted to investigate the association of Apolipoprotein E (ApoE) polymorphism with the treatment response to ranibizumab for exudative AMD.
|
26398858 |
2016 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to determine the potential association between 10 single nucleotide polymorphisms (SNPs) located in 4 different genetic regions (CFI, COL8A1, LIPC, and APOE), and choroidal neovascularization in age-related macular degeneration and the development of choroidal neovascularization in highly myopic eyes of a Caucasian population.
|
27643879 |
2016 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Here, we propose that ApoE serves a fundamentally different purpose in regulating cholesterol homeostasis in the retinal pigment epithelium and this could explain why allelic risk factors are flipped for AMD compared to Alzheimer's disease.
|
26427386 |
2016 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
A logistic model for early AMD found a significant association with AD diagnosis (p < 0.0001), after adjusting for confounders (age, smoking, hypertension, high and low density lipoproteins, cataract surgery and APOE ε4 carrier status).
|
27335042 |
2016 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants.
|
26691988 |
2016 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, there have been no reports on gene expression patterns in animal models of non-neovascular AMD with abnormal lipid metabolism such as apolipoprotein E knockout and human apolipoprotein E2 transgenic mice.
|
25867331 |
2015 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our study did not confirm the impact of rs2075650 on advanced AMD risk, indicating that rs2075650 is unlikely a superior marker for APOE/TOMM40 susceptible region with advanced AMD in Han Chinese population.
|
25304313 |
2015 |
Age related macular degeneration
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We show that subretinal MPs in AMD patients accumulate on the RPE and express high levels of APOE.
|
25604058 |
2015 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The individual effects on the risk of AMD for 18 of the 19 SNPs were in a consistent direction with those previously reported, including a protective effect of the APOE ε4 allele.
|
26176866 |
2015 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Our study shows that pathogenic subretinal inflammation is APOE isoform-dependent and provides the rationale for the previously unexplained implication of the APOE2 isoform as a risk factor and the APOE4 isoform as a protective factor in AMD pathogenesis.
|
26446211 |
2015 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
A spectrum of complement dysregulation was modeled on the APOE4 AMD mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation, and by crossing them to soluble-complement-receptor-1-related protein y (sCrry) mice, in which sCrry acts as a potent inhibitor of mouse complement acting in a manner similar to CFH.
|
24664701 |
2014 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Previous reports suggest that the outcome of age-related macular degeneration treatment is dependent on variants in the apolipoprotein E (APOE) gene.
|
25077528 |
2014 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
A total of 24 variants from five genes (BCMO1, BCO2, NPCL1L1, ABCG8, and FADS2) not previously related to AMD and four genes related to AMD in previous studies (SCARB1, ABCA1, APOE, and ALDH3A2) were associated independently with AMD, after adjusting for age and ancestry.
|
24346170 |
2014 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To evaluate the effect of simvastatin on AMD progression and the effect modification by polymorphism in apolipoprotein E (ApoE) and complement factor H (CFH) genes.
|
24391822 |
2013 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
GWAS meta-analysis confirmed previously reported association of variants at the complement factor H (CFH) (peak P = 1.5×10(-31)) and age-related maculopathy susceptibility 2 (ARMS2) (P = 4.3×10(-24)) loci, and suggested Apolipoprotein E (ApoE) polymorphisms (rs2075650; P = 1.1×10(-6)) associated with early AMD.
|
23326517 |
2013 |
Age related macular degeneration
|
0.500 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E gene associations in age-related macular degeneration: the Melbourne Collaborative Cohort Study.
|
22328704 |
2012 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The CD subtype of AMD was significantly associated with current smoking as well as variants in the complement factor H (CFH), age-related maculopathy susceptibility 2 (ARMS2), complement factor B/complement component 2 (CFB/C2), complement component 3 (C3), and apolipoprotein E (APOE) genes.
|
22933840 |
2012 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The genetics of AMD began initially with the appreciation of familial aggregation and increase risk and expanded with the initial association of APOE variants with the disease.
|
22561651 |
2012 |
Age related macular degeneration
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Consistent with a pathogenic role for Aβ, we show here that a mouse model of AMD that invokes multiple factors that are known to modify AMD risk (aged human apolipoprotein E 4 targeted replacement mice on a high-fat, cholesterol-enriched diet) presents with Aβ-containing deposits basal to the retinal pigmented epithelium (RPE), histopathologic changes in the RPE, and a deficit in scotopic electroretinographic response, which is reflective of impaired visual function.
|
21690377 |
2011 |