|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein glomerulopathy (LPG) is a rare autosomal dominant renal disease with incomplete penetrance, associated with specific protein-modifying mutations in the APOE gene.
|
30685233 |
2020 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Mutations in apoE may also cause lipoprotein glomerulopathy.
|
30598326 |
2019 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A novel apolipoprotein E mutation caused by a five amino acid deletion in a Chinese family with lipoprotein glomerulopathy: a case report.
|
31092271 |
2019 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
BEFREE |
Renal biopsy revealed typical LPG lesions with whorled, mesh-like material in dilated glomerular capillary lumens that stained positive for Sudan Ⅲ and apoE. apoE gene analysis revealed a T-to-C point mutation at amino acid 173 that caused a substitution of a proline residue for a leucine residue, which has not been reported previously.
|
29398675 |
2018 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
BEFREE |
LPG provides a disease model by which to explore pathogenic roles of apoE in common diseases.
|
24165683 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
BEFREE |
On the other hand, the administration of fibrate with the intensive control of triglyceride and apolipoprotein E particularly from the early phase will ameliorate LPG and prevent renal dysfunction.
|
24149835 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E mutations: a comparison between lipoprotein glomerulopathy and type III hyperlipoproteinemia.
|
24570178 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
An atlas of genetic influences on human blood metabolites.
|
24816252 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
APOE Kyoto mutation was found in a new Chinese patient with LPG, accompanied by Cys112Arg.
|
25300642 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Rarely, mutations in apolipoprotein E are associated with lipoprotein glomerulopathy, a condition characterized by progressive proteinuria and renal failure with varying degrees of plasma remnant accumulation.
|
24405372 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Hereditary features, treatment, and prognosis of the lipoprotein glomerulopathy in patients with the APOE Kyoto mutation.
|
24025644 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Lipoprotein glomerulopathy is an inherited renal disease characterized by unique lipoprotein thrombi in the glomerulus and is associated with the APOE mutation.
|
24487366 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The recognition that structural destabilization may underlie the association between apoE mutations and LPG can be key for development of new innovative treatments for this rare disease.
|
24149834 |
2014 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the counterpart APOE allele is not likely associated with the onset of LPG.
|
23407349 |
2013 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
BEFREE |
These results suggest that the impairment of macrophage function resulting from FcRγ deficiency plays a principal role in the development of LPG in the presence of apoE abnormalities.
|
22863838 |
2012 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Several gene mutations of apoE have been reported to be associated with LPG.
|
21325775 |
2011 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GermlineCausalMutation
|
disease |
ORPHANET |
Lipoprotein glomerulopathy.
|
21464714 |
2011 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
Lipoprotein glomerulopathy is clinically characterized by proteinuria and progression to renal failure and is caused by glomerular lipoprotein thrombi formation in association with increased levels of serum apolipoprotein E. The disease has a male predominance and can affect virtually any age group.
|
20121619 |
2010 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
A new apolipoprotein E mutation, apoE Las Vegas, in a European-American with lipoprotein glomerulopathy.
|
20624773 |
2010 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Our research indicates that APOE Maebashi (Arg142-Leu144-->0) is a common mutation in Chinese LPG.
|
20090368 |
2010 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
BEFREE |
Further studies will be needed to clarify the role of apolipoprotein E Hong Kong and its interaction with apolipoprotein E Kyoto in the pathogenesis of lipoprotein glomerulopathy.
|
19197098 |
2009 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
Biomarker
|
disease |
BEFREE |
Multiple factors other than apoE were involved in the pathogenesis of LPG.
|
18264944 |
2008 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The apoE gene in a family with 4 LPG patients was sequenced.
|
18046082 |
2008 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
UNIPROT |
APOE Kyoto mutation in European Americans with lipoprotein glomerulopathy.
|
18077821 |
2007 |
|
LIPOPROTEIN GLOMERULOPATHY
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Results suggest that there are no apo E gene mutations present in our LPG patients, including previously reported apo E mutations associated with LPG.
|
17918142 |
2007 |