|
21-hydroxylase deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The study involved a monogenic analysis of CYP21A2 in patients (375 nonclassical 21OHD [NC21OHD] children; 306 hyperandrogenic 21OHD carriers, n = 306) and a polygenic association study (CAPN10-UCSNP44, PON1-108, TNFR2-M196R, IGF2-ApaI and IRS1-G972R polymorphisms) of 170 hyperandrogenic carriers plus 277 family members (control groups).
|
19039234 |
2009 |
|
Abnormality of cardiovascular system morphology
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the dentition
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the skeletal system
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The consequent overexpression of Igf2 results in most of the symptoms of Beckwith-Wiedemann syndrome, including prenatal overgrowth, polyhydramnios, fetal and neonatal lethality, disproportionate organ overgrowth including tongue enlargement, and skeletal abnormalities.
|
9349812 |
1997 |
|
Abnormality of the ureter
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Acute Confusional Senile Dementia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes?
|
15750215 |
2005 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
For one of those genes, IGF2, an important role in childhood overgrowth syndromes as well as in the development of adult acute leukemia has been suggested, providing a possible explanation for our presented case.
|
12165460 |
2002 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of imprinting of IGF-II gene in children with acute lymphoblastic leukemia.
|
12804639 |
2003 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transplantation of IGF-2-overexpressing eEPCs in acute myocardial infarction may improve early myocardial function by enhancing proliferation and limiting the inflammatory response and apoptosis.
|
28950284 |
2017 |
|
Acute pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, the regulatory relationship between miR‑3941 and insulin‑like growth factor 2 (IGF2) was explored, as well as the association between miR‑3941 and the phosphatidylinositol‑4,5‑bisphosphate 3‑kinase/protein kinase B (PI3K/AKT) pathway. miR‑3941 was significantly down‑regulated in patients with acute pneumonia (P<0.01).
|
29328418 |
2018 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Addiction to the IGF2-ID1-IGF2 circuit for maintenance of the breast cancer stem-like cells.
|
27546618 |
2017 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We have recently reported abnormal insulin-like growth factor-II (IGF-II) mRNA levels in a number of human colorectal adenocarcinomas.
|
1713573 |
1991 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To the best of our knowledge, this is the first study evaluating IGF2 by IHC, as well as, correlating it with the expression of the two tumor suppressor genes, p53 and FHIT, in esophageal tissue. p53 expression was threefold higher than normal in dysplasias of squamous epithelium and adenocarcinoma, while it was eightfold higher in squamous cell carcinoma.
|
21668571 |
2012 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The IGF-1R and its ligands, mainly IGF-1 and IGF-2, have been suggested to play pivotal roles in proliferation, survival and migration of adenocarcinoma cells of the colon/rectum.
|
22159423 |
2012 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
IGF-II-immunoreactive cells were found in nearly all the 18 insulin-producing tumours (16/18), in a minority of the other endocrine tumours, but not in pancreatic adenocarcinomas.
|
11398994 |
2001 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
LOI of IGF2 was seen more frequently in moderately to poorly differentiated adenocarcinomas.
|
11536368 |
2001 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IGF-II mRNA was significantly increased by 30% in adenocarcinoma compared to that in benign epithelium (P < 0.03).
|
8855837 |
1996 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Altered methylation at Insulin-like Growth Factor 2 (IGF2) regulatory regions has previously been associated with obesity, and several malignancies including colon, esophageal, and prostate adenocarcinomas, presumably via changes in expression and/or loss of imprinting, but the functional significance of these DNA methylation marks have not been demonstrated in humans.
|
22392079 |
2012 |
|
Adenocarcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of IGF 2 and IGF 1R was correlated with the expression of IGF 2R and apoptosis rate in 59 human endometrial adenocarcinomas, 10 endometrial hyperplasias and 7 normal tissues.
|
17399767 |
2007 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In 40% of informative adenocarcinomas expressing the highest values of IGF-2 and Ki-67 proteins, M6P/IGF-2R gene had LOH at one allele and a mutation in another allele.
|
15514114 |
2005 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
High concentrations of insulin-like growth factor (IGF)-I and IGF-II have been demonstrated in human colonic adenocarcinomas and exert mitogenic effects through paracrine/autocrine interactions with the IGF-I receptor (IGF-IR).
|
12412161 |
2002 |
|
Adenocarcinoma of colon
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Tumor IGF-II content in a patient with a colon adenocarcinoma correlates with abnormal expression of the gene.
|
1713573 |
1991 |
|
Adenocarcinoma of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that the IGF-II/Man-6-P receptor may also be involved in development of adenocarcinoma of the colon.
|
10205209 |
1999 |
|
Adenocarcinoma of large intestine
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of IGF-II and Bcl-2 was correlated with the clinical manifestation of colorectal adenocarcinoma; thus, the assessment of both IGF-II and Bcl-2's status will provide important information regarding the diagnosis and prognosis of colorectal adenocarcinoma.
|
21380782 |
2012 |