IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE All patients with endogenous hypoglycaemia related to inappropriate insulin or to IGF2 secretion between 2012 and 2016 and considered normoglycaemic with medical treatment (absence of clinical hypoglycaemia and self-monitoring blood glucose in the normal range) were enroled and underwent a six-day continuous glucose monitoring (CGM) recording. 30817011 2019
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Non-islet cell hypoglycemia (NICH) is hypoglycemia due to the overproduction of insulin-like growth factor-2 (IGF-2) and its precursors which can activate the insulin receptor. 31156561 2019
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE Further evaluation revealed elevated IGF-II levels consistent with non-islet cell tumor-induced hypoglycemia. 31328061 2019
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE Moreover, we showed that two patients without hypoglycemia also had a small amount of big IGF2 in their serum. 29897468 2018
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Also, it is known that insulin-like growth factor 2 is an etiology of non-islet cell tumor hypoglycemia. 28012446 2017
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Solitary fibrous tumors occasionally present with hypoglycemia because of the excessive release of insulin-like growth factor II. 27585487 2016
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Tumor-derived big IGF-II is responsible for enhanced insulin-like effects in the body through complicated mechanisms, leading to hypoglycemia. 26073062 2015
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE Previous reports suggest a role for IGF2 over-expression in the pathogenesis of these tumours, implicated in triggering hypoglycaemia in some patients. 20527023 2010
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE We investigated the imprinting control and promoter usage for IGF2 expression to identify a mechanism for increased IGF-II production in non-islet-cell tumor hypoglycemia. 19383775 2009
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE Defective expression of prohormone convertase 4 and enhanced expression of insulin-like growth factor II by pleural solitary fibrous tumor causing hypoglycemia. 18552458 2008
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE These results suggest that a dysregulation of gene expression and imprinting of chromosome 11p15 region is associated with tumour growth and IGF-II overexpression in non-islet-cell tumour hypoglycaemia. 10931103 2000
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Hypoglycaemia associated with the production of insulin-like growth factor II and insulin-like growth factor binding protein 6 by a haemangiopericytoma. 10468998 1999
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE High-molecular weight IGF-2 expression in a haemangiopericytoma associated with hypoglycaemia. 9236865 1997
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Because the serum level of IGF binding protein-3 was low, whereas the serum insulin level and other endocrinological examinations were normal, we speculate that the mechanism of the hypoglycemia was associated with the tumor-produced IGF2. 8760024 1996
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE We postulated that the pathogenesis of her hypoglycemia involved production of IGF-II by her neuroblastoma, leading to GH suppression and an abnormally elevated ratio of IGF to IGF binding protein. 7658270 1995
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE An insulin-like growth factor II-producing histiocytoma associated with hypoglycemia: analysis of the peptide, its gene expression, and glucose transporter isoforms. 1311795 1992
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE In 25 of 28 patients with this type of hypoglycemia we found 1.5-8-fold elevated serum levels of immunoreactive big (15-25 kD), but decreased levels of normal IGF II. 1281841 1992
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE There is now convincing evidence that some tumors secrete sufficient IGF-II to have systemic endocrine effects as recognized as nonislet cell tumor hypoglycemia. 1718747 1991
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE The former comprised a greater proportion of total IGF-II, in patients with hypoglycemia. 2159026 1990
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE We found that 57% +/- 4.6% of the IGF-II in sera from patients with hypoglycemia was present as big IGF-II compared with 22% +/- 3% in patients with euglycemia with hepatomas (not significantly different from that in normal controls). 2170553 1990
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE We suggest that the primary event in tumor-induced hypoglycemia is overproduction of IGF-II by the tumor, which gives rise to hypoglycemia by a dual mechanism: increased glucose utilization mediated by the insulin-like actions of IGF-II and inhibition of GH secretion. 2646313 1989
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 AlteredExpression disease BEFREE These data suggest that nonislet cell tumors associated with hypoglycemia produce large amounts of IGF-II mRNA and that this IGF-II mRNA appears to be the product of an IGF-II gene, which is apparently normal in the region encoding mature IGF-II peptide. 2584352 1989
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease CTD_human Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. 3185662 1988
CUI: C0020615
Disease: Hypoglycemia
Hypoglycemia
0.400 Biomarker disease BEFREE Synthesis and secretion of insulin-like growth factor II by a leiomyosarcoma with associated hypoglycemia. 3185662 1988