Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This review summarises the critical discussion at an international workshop held under the auspices of The European Network for Cancer Research in Children and Adolescents (ENCCA) consortium, where the potential for drug development to target IGF2 and the WT epigenome was debated.
|
25478630 |
2014 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
With the success in establishing mice nephroblastoma models through over-expressing IGF2 and deleting WT1, and advances in understanding the ENU-induced rat model, we are now able to explore the molecular and cellular mechanisms induced by these genetic, epigenetic, and miRNA alterations in animal models to understand the development of Wilms tumor.
|
25018051 |
2014 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Epigenetic abnormalities at the IGF2/H19 locus play a key role in the onset of Wilms tumor.
|
23074036 |
2013 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This contrasts the situation we found at the IGF2/H19 locus, which shows high overexpression of IGF2 and inversely correlated expression of the H19 gene in WT.
|
23825673 |
2013 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
This is the first comprehensive study of the four genes, and the results supported the hypothesis that the lower incidence of IGF2 LOI contributes to the lower incidence of WTs in Japanese children.
|
22409817 |
2012 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of insulin-like growth factor 2 (IGF2), an imprinted gene located on chromosome 11p15, has been reported as a characteristic feature in various embryonal tumors, including Wilms tumor (WT).
|
21174059 |
2011 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
By contrast the expression of a third Wilms tumour-related gene, WT1, was completely uncorrelated to the expression of IGF-II and JIP.
|
20044608 |
2009 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor.
|
19293570 |
2009 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours.
|
19596915 |
2009 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour.
|
18245780 |
2008 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Epigenetic changes occur frequently in Wilms' tumor (WT), especially loss of imprinting (LOI) of IGF2/H19 at 11p15.
|
18644976 |
2008 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We describe a family with overgrowth in three generations and Wilms' tumor in two generations, with paternal inheritance of a cis-duplication at 11p15.5 spanning the BWS IC1 region and including H19, IGFII, INS, and TH.
|
17325026 |
2007 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Loss of imprinting (LOI) of the IGF2 gene (which encodes insulin-like growth factor II) is the most common genetic or epigenetic alteration in Wilms tumor; LOI involves aberrant activation of the normally repressed maternally inherited allele.
|
17686827 |
2007 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Using molecular analysis, a loss of Wilms' tumor gene 1 (WT1) transcript and a biallelic expression of insulin growth factor 2 (IGF2) could be revealed.
|
16177880 |
2006 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor.
|
16518847 |
2006 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Thus, a genetic (16q LOH) and an epigenetic (LOI of IGF2) alteration in WT are linked, the first such association described.
|
15761865 |
2005 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The question arises as to whether DLK1 also undergoes LOI in Wilms tumour, or whether the LOI mechanism is restricted to the H19/IGF2 domain.
|
15677533 |
2005 |
Nephroblastoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the difference in incidence of Wilms' tumour between children of east-Asian descent and white children is due to variations in proportion of tumours with loss of IGF2 imprinting (IGF2 LOI).
|
14962525 |
2004 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues.
|
12702581 |
2003 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, some WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating that methylation of these sites is necessary but not sufficient for LOI in WT.
|
11431321 |
2001 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor.
|
11717330 |
2001 |
Nephroblastoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Genomic imprinting of insulin-like growth factor 2 (IGF2) has been shown to play an important role in the development of Wilms' tumor and adult cancers including lung and esophageal cancer.
|
11053988 |
2000 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively.
|
10731720 |
2000 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, the analysis of the expression of other 11p15 imprinted genes and kidney-developmentally regulated genes indicates that IGF2 overexpression, inappropriate coexpression of RET and GDNF and, in some cases, down-regulation of CDKN1C may also play an important role in the pathogenesis of WT.
|
10749116 |
2000 |
Nephroblastoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The LOI of IGF2 may induce increased or deregulated IGF2 expression which could initiate the onset of WT.
|
9589901 |
1998 |