IGF2, insulin like growth factor 2, 3481

N. diseases: 604; N. variants: 19
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE This review summarises the critical discussion at an international workshop held under the auspices of The European Network for Cancer Research in Children and Adolescents (ENCCA) consortium, where the potential for drug development to target IGF2 and the WT epigenome was debated. 25478630 2014
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE With the success in establishing mice nephroblastoma models through over-expressing IGF2 and deleting WT1, and advances in understanding the ENU-induced rat model, we are now able to explore the molecular and cellular mechanisms induced by these genetic, epigenetic, and miRNA alterations in animal models to understand the development of Wilms tumor. 25018051 2014
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE Epigenetic abnormalities at the IGF2/H19 locus play a key role in the onset of Wilms tumor. 23074036 2013
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE This contrasts the situation we found at the IGF2/H19 locus, which shows high overexpression of IGF2 and inversely correlated expression of the H19 gene in WT. 23825673 2013
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE This is the first comprehensive study of the four genes, and the results supported the hypothesis that the lower incidence of IGF2 LOI contributes to the lower incidence of WTs in Japanese children. 22409817 2012
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE Overexpression of insulin-like growth factor 2 (IGF2), an imprinted gene located on chromosome 11p15, has been reported as a characteristic feature in various embryonal tumors, including Wilms tumor (WT). 21174059 2011
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE By contrast the expression of a third Wilms tumour-related gene, WT1, was completely uncorrelated to the expression of IGF-II and JIP. 20044608 2009
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE Inherited and Sporadic Epimutations at the IGF2-H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumor. 19293570 2009
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE Expression of JNK-interacting protein JIP-1 and insulin-like growth factor II in Wilms tumour cell lines and primary Wilms tumours. 19596915 2009
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE Different mechanisms cause imprinting defects at the IGF2/H19 locus in Beckwith-Wiedemann syndrome and Wilms' tumour. 18245780 2008
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE Epigenetic changes occur frequently in Wilms' tumor (WT), especially loss of imprinting (LOI) of IGF2/H19 at 11p15. 18644976 2008
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE We describe a family with overgrowth in three generations and Wilms' tumor in two generations, with paternal inheritance of a cis-duplication at 11p15.5 spanning the BWS IC1 region and including H19, IGFII, INS, and TH. 17325026 2007
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE Loss of imprinting (LOI) of the IGF2 gene (which encodes insulin-like growth factor II) is the most common genetic or epigenetic alteration in Wilms tumor; LOI involves aberrant activation of the normally repressed maternally inherited allele. 17686827 2007
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE Using molecular analysis, a loss of Wilms' tumor gene 1 (WT1) transcript and a biallelic expression of insulin growth factor 2 (IGF2) could be revealed. 16177880 2006
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE Association of 11q loss, trisomy 12, and possible 16q loss with loss of imprinting of insulin-like growth factor-II in Wilms tumor. 16518847 2006
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE Thus, a genetic (16q LOH) and an epigenetic (LOI of IGF2) alteration in WT are linked, the first such association described. 15761865 2005
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE The question arises as to whether DLK1 also undergoes LOI in Wilms tumour, or whether the LOI mechanism is restricted to the H19/IGF2 domain. 15677533 2005
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 GeneticVariation disease BEFREE We investigated whether the difference in incidence of Wilms' tumour between children of east-Asian descent and white children is due to variations in proportion of tumours with loss of IGF2 imprinting (IGF2 LOI). 14962525 2004
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE IGF2-AS was expressed at levels comparable with IGF2 sense expression derived from promoters P1 and P2 in normal tissue and in breast, ovarian, and Wilms' tumor tissues. 12702581 2003
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE However, some WTs with normal imprinting of IGF2 also show aberrant methylation of CTCF binding sites, indicating that methylation of these sites is necessary but not sufficient for LOI in WT. 11431321 2001
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE Loss of imprinting of insulin-like growth factor-II (IGF2) gene in distinguishing specific biologic subtypes of Wilms tumor. 11717330 2001
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 Biomarker disease BEFREE Genomic imprinting of insulin-like growth factor 2 (IGF2) has been shown to play an important role in the development of Wilms' tumor and adult cancers including lung and esophageal cancer. 11053988 2000
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE Interestingly, PEG8/IGF2AS and IGF2 were found to be overexpressed in Wilms' tumor samples, at levels over ten and a hundred times higher than that in normal kidney tissues neighboring the tumors, respectively. 10731720 2000
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE In addition, the analysis of the expression of other 11p15 imprinted genes and kidney-developmentally regulated genes indicates that IGF2 overexpression, inappropriate coexpression of RET and GDNF and, in some cases, down-regulation of CDKN1C may also play an important role in the pathogenesis of WT. 10749116 2000
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma
0.500 AlteredExpression disease BEFREE The LOI of IGF2 may induce increased or deregulated IGF2 expression which could initiate the onset of WT. 9589901 1998