|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Differentially methylated regions (DMRs) of two imprinted genes, insulin-like growth factor 2 (IGF2) and H19, have been associated with obesity due to their important roles in regulating body composition, but have not been examined in relation to intra-abdominal fat depots.
|
30277114 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using candidate gene approach, obesity- (insulin-like growth factor 2 (IGF2), proopiomelanocortin (POMC)) and vitamin D metabolism-related genes (1-alfa-hydroxylase (CYP27B1), VDR) regulated by DNA methylation were selected.
|
28787727 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, elevated serum preptin and decreased osteocalcin concentrations, together with insulin resistance, are associated with obesity and overweight.
|
25675353 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: Role of obesity and sex.
|
26056743 |
2015 |
|
Obesity
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In this study, our aim was to determine associations between preconceptional obesity and DNA methylation profiles in the offspring, particularly at the differentially methylated regions (DMRs) of the imprinted Insulin-like Growth Factor 2 (IGF2) gene.
|
23388414 |
2013 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These data imply that paternal obesity affects the normal IGF2 methylation in the sperm and this in turn alters the expression of IGF2 in the baby.
|
23388448 |
2013 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Altered methylation at Insulin-like Growth Factor 2 (IGF2) regulatory regions has previously been associated with obesity, and several malignancies including colon, esophageal, and prostate adenocarcinomas, presumably via changes in expression and/or loss of imprinting, but the functional significance of these DNA methylation marks have not been demonstrated in humans.
|
22392079 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
IGF2/H19 DNA methylation could represent a cornerstone in linking birth weight and fetal metabolic programming of late onset obesity.
|
22907587 |
2012 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed the molecular screening of two IGF2 polymorphisms (6815 A/T, 820 G/A), in 227 obese children to evaluate the potential association between IGF2 variants with either obesity or high blood pressure (assessed with a 24-h holter system) or both.
|
20057340 |
2010 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Some reports also refer to the effect of disturbances in the expression of the insulin-like growth factor (IGF) system on pancreas beta-cell function in humans and IGF-2/ApaI polymorphisms have been associated with obesity and features of the metabolic syndromes.
|
19560381 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Study of association between common variation in the insulin-like growth factor 2 gene and indices of obesity and body size in middle-aged men and women.
|
17488802 |
2007 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes.
|
16251897 |
2006 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In steatohepatitis, an increase of the protein expression of mitochondrial antigens, IL-1R1, IGF2 and TGFB1 was also observed, interleukin 1 receptor being always strongly expressed in steatohepatitis linked to alcohol or obesity.
|
16344856 |
2006 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In adult humans, polymorphisms of the IGF2 gene have been associated with predisposition to obesity.
|
16102992 |
2005 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, human population studies have established significant associations between specific polymorphisms at the insulin-like growth factor II gene and obesity which is an important risk factor for atherosclerosis.
|
14501587 |
2003 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
The subtelomeric region of 11p harbours three closely linked genes, TH, INS and IGF2, that have been associated with obesity, size at birth, type I diabetes, polycystic ovary syndrome, overgrowth in Beckwith-Wiedemann syndrome and possibly hypertension.
|
11935324 |
2002 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Paternal transmission of the very common class I INS VNTR alleles predisposes to childhood obesity.
|
11528401 |
2001 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity.
|
10573016 |
2000 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Several candidate genes, including tubby (tub), multigenic obesity 1 (Mob1), adult obesity and diabetes (Ad), and insulin-like growth factor-2 (Igf2), map to murine regions homologous to the QTL region identified on rat Chr.1.
|
9169130 |
1997 |