|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
We identified one case each of FGR and PIH showing hypomethylation of H19-DMR and IGF2-DMRs only in the placenta, but not in cord blood, from the first case/control set.
|
31370882 |
2019 |
|
Fetal Growth Retardation
|
0.900 |
PosttranslationalModification
|
phenotype |
BEFREE |
Further mediation analyses showed that IGF2 methylation mediated about 40% of the effects of BDE-17-190 in umbilical cord blood on neonatal FGR.
|
31655276 |
2019 |
|
Fetal Growth Retardation
|
0.900 |
GeneticVariation
|
phenotype |
BEFREE |
Gene mutations in the IGF1 and IGF2 genes have been described in patients presenting intrauterine growth retardation and postnatal short stature.
|
29249625 |
2018 |
|
Fetal Growth Retardation
|
0.900 |
AlteredExpression
|
phenotype |
BEFREE |
The infant with IUGR has a higher serum level of IGF2 if has A/G IGF2-ApaI genotype and higher values of IGF2R if it has the A/A genotype.
|
28460554 |
2018 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
We used a well-characterized mouse model of FGR in which placental Igf-2 production is lost due to deletion of the placental specific <i>Igf-2</i> P<sub>0</sub> promotor.
|
30443254 |
2018 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
Genetic disruption of the oncogenic HMGA2-PLAG1-IGF2 pathway causes fetal growth restriction.
|
28796236 |
2018 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
In the functional significance of gene, low-density lipoprotein receptor-related protein 10 (LRP10) was significantly increased (6-fold) and insulin-like growth factor (IGF-2) was dramatically increased (17-fold) in the FGR cases.The results show that the important brain-related genes are predominantly down-regulated in the intrauterine growth restriction fetuses during the second trimester of pregnancy.
|
29480850 |
2018 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
Insulin-like growth factor-II (IGF2) deficiency in humans, as well as in mice, leads to intrauterine growth restriction and decreased neonatal glycogen stores.
|
30016152 |
2018 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
Finally alterations in vulnerable epigenetic marks of imprinted genes such as H19/IGF2, during early stages of embryonic development result in intrauterine growth restriction.
|
27898587 |
2017 |
|
Fetal Growth Retardation
|
0.900 |
PosttranslationalModification
|
phenotype |
BEFREE |
In addition, significantly elevated odds of FGR birth were associated with increasing DNA methylation of HSD11B2 and WNT2, and decreasing DNA methylation of IGF2.
|
26678531 |
2016 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Paternally Inherited IGF2 Mutation and Growth Restriction.
|
26154720 |
2015 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Paternally Inherited IGF2 Mutation and Growth Restriction.
|
26154720 |
2015 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
We propose that miR-141 may participate in a miR-141-PLAG1-IGF2 network relating to FGR development.
|
23554918 |
2013 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
Notably, at 28 weeks' gestation there was increased IGF2 (3.9-fold), placental growth hormone (2.7-fold), and IGF BP2 (2.1-fold) expression in maternal blood in women destined to develop FGR at term (P < .05).
|
23583218 |
2013 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
A reduction in substrate supply in fetal life, resulting in chronic hypoxaemia and intrauterine growth restriction, results in increased cardiac IGF-1R, IGF-2 and IGF-2R gene expression; and there is also evidence for a role of the IGF-2 receptor in the ensuing cardiac hypertrophy.
|
22774980 |
2012 |
|
Fetal Growth Retardation
|
0.900 |
GeneticVariation
|
phenotype |
BEFREE |
Our results suggest the involvement of the IGF2 imprinted gene in placental function and fetal growth and the possible association of epigenetic alterations with the pathophysiology of fetal growth restriction.
|
21805044 |
2011 |
|
Fetal Growth Retardation
|
0.900 |
AlteredExpression
|
phenotype |
BEFREE |
In placentas from pregnancies with IUGR an overexpression of the IGF-2 and the insulin-like growth factor binding protein (IGFBP)-3 genes was found.
|
21823995 |
2011 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
Using quantitative approaches, we explored the epigenetic modulation of IGF2/H19 during human development in 60 normal and 66 idiopathic IUGR (Intrauterine Growth Restriction) pregnancies, studying embryonic (cord blood) and extraembryonic (placenta and umbilical cord) tissues.
|
20418667 |
2010 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
There were significantly lower concentrations of glucose, insulin, IGF-1, and IGF-II in the fetal cord blood of pregnancies with IUGR (p<0.05).
|
20106611 |
2010 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
BEFREE |
A reduction in placental IGF2 could be an adaptive response to restrict fetal growth in the presence of abnormal placentation or a response to poor fetal growth itself.
|
20060582 |
2010 |
|
Fetal Growth Retardation
|
0.900 |
GeneticVariation
|
phenotype |
BEFREE |
Severe intrauterine growth retardation and atypical diabetes associated with a translocation breakpoint disrupting regulation of the insulin-like growth factor 2 gene.
|
18728168 |
2008 |
|
Fetal Growth Retardation
|
0.900 |
AlteredExpression
|
phenotype |
LHGDN |
Placental IGF2 expression in normal and intrauterine growth restricted (IUGR) pregnancies.
|
17919721 |
2008 |
|
Fetal Growth Retardation
|
0.900 |
AlteredExpression
|
phenotype |
LHGDN |
A break point 184 kb upstream of the paternally derived IGF2 gene, separating it from some telomeric enhancers, resulted in reduced expression in some mesoderm-derived adult tissues causing intrauterine growth retardation, short stature, lactation failure, and insulin resistance with altered fat distribution.
|
18728168 |
2008 |
|
Fetal Growth Retardation
|
0.900 |
AlteredExpression
|
phenotype |
BEFREE |
At lower significance, we found IGF2 mRNA decreased and CDKN1C mRNA increased in the IUGR cases.
|
16125225 |
2006 |
|
Fetal Growth Retardation
|
0.900 |
Biomarker
|
phenotype |
CTD_human |
Role of pro-IGF-II processing by proprotein convertase 4 in human placental development.
|
16040806 |
2005 |