|
Muscular Dystrophy, Duchenne
|
0.010 |
Biomarker
|
disease |
BEFREE |
Blockade of IGF2R by neutralizing antibodies stimulated muscle regeneration, induced force recovery and normalized capillary architecture in dystrophic mdx mice representing an encouraging starting point for the development of new biological therapies for DMD.
|
31793167 |
2020 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry (IHC) and Cox regression analysis showed low IGF2R expression were significantly associated with more advanced histological grade; high clinical stage; lymph node metastasis and poorer overall survival for patients with bladder cancer.
|
31847523 |
2020 |
|
Malignant tumor of cervix
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, on the basis of transcriptome analysis of TCGA and GEO open datasets, we show that IGF2R is upregulated and correlated with poor prognosis in cervical cancer.
|
31748500 |
2019 |
|
Agenesis of corpus callosum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The protein expression level of IGF2, IGF1R and IGF2R was evaluated by immunohistochemistry in 17 human ACCs and the mRNA expression level of IGF1, IGF2, IGF1R, IR isoforms A and B, IGF2R, IGF-Binding-Proteins[IGFBP]-1, 2, 3 and 6 was evaluated by RT-qPCR in 12 samples.
|
30838516 |
2019 |
|
Aplasia Cutis Congenita
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The protein expression level of IGF2, IGF1R and IGF2R was evaluated by immunohistochemistry in 17 human ACCs and the mRNA expression level of IGF1, IGF2, IGF1R, IR isoforms A and B, IGF2R, IGF-Binding-Proteins[IGFBP]-1, 2, 3 and 6 was evaluated by RT-qPCR in 12 samples.
|
30838516 |
2019 |
|
Cervix carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, on the basis of transcriptome analysis of TCGA and GEO open datasets, we show that IGF2R is upregulated and correlated with poor prognosis in cervical cancer.
|
31748500 |
2019 |
|
Recurrent tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The present study focused on the effects of the expression of the tumor suppressor gene insulin‑like growth factor‑2 receptor (IGF2R) on patient survival and tumor recurrence in patients with HCC; this study paid specific attention to the influence of transarterial chemoembolization (TACE) prior to surgery.
|
30720132 |
2019 |
|
Intestinal adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Bi-allelic Igf2r expression suppressed intestinal adenoma (Apc<sup>Min</sup>).
|
31388182 |
2019 |
|
Primary Effusion Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We show in the present study that vIL-6 can promote productive replication and latent PEL cell viability through upregulation of the mannose-6-phosphate- and peptide hormone-interacting receptor IGF2R, which is a positive factor in HHV-8 biology via these activities.
|
30541844 |
2019 |
|
Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
RT‑PCR demonstrated that the mRNA expression levels of IGF2R were downregulated in HCC compared with in TST samples (P=0.004), which was associated with a worse recurrence‑free survival of patients with HCC (P=0.002) and a lower occurrence of cirrhosis (P=0.05).
|
30720132 |
2019 |
|
Non-Neoplastic Disorder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA expression levels of IGF2R were measured in primary human HCC and corresponding non‑neoplastic tumor‑surrounding tissue (TST) by reverse transcription‑polymerase chain reaction (RT‑PCR) (n=92).
|
30720132 |
2019 |
|
cervical cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, on the basis of transcriptome analysis of TCGA and GEO open datasets, we show that IGF2R is upregulated and correlated with poor prognosis in cervical cancer.
|
31748500 |
2019 |
|
Obesity-Associated Insulin Resistance
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results characterize the miR-143-3p-IGF2R pathway as a potential target for the treatment of obesity-associated insulin resistance.
|
30392876 |
2019 |
|
Angina Pectoris
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Fifty patients with angina (65 ± 9 years of age) and 20 age-matched healthy control subjects underwent adenosine stress CMR (1.5- and 3-T) to assess left ventricular function, inducible ischemia (myocardial perfusion reserve index [MPRI]; myocardial blood flow [MBF]), and infarction (late gadolinium enhancement).
|
29495996 |
2018 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of insulin receptor (IR) isoforms, IGF-IR or insulin-like growth factor-II receptor (IGF-IIR) in VSMCs apoptosis during advanced atherosclerosis remains unclear.
|
29463262 |
2018 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, the role of insulin receptor (IR) isoforms, IGF-IR or insulin-like growth factor-II receptor (IGF-IIR) in VSMCs apoptosis during advanced atherosclerosis remains unclear.
|
29463262 |
2018 |
|
Heart Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The insulin-like growth factor type 2 receptor (IGF2R) overexpression has been implicated in heart disease progression.
|
29136764 |
2018 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The current review discusses about the expression, structure, and functional role of E4BP4 in signaling processes with emphasis on calcium signaling mechanisms, autocrine signaling, and insulin-like growth factor II receptor-mediated processes regulated by E4BP4 that may regulate the pathogenesis of HF.
|
29856483 |
2018 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The current review discusses about the expression, structure, and functional role of E4BP4 in signaling processes with emphasis on calcium signaling mechanisms, autocrine signaling, and insulin-like growth factor II receptor-mediated processes regulated by E4BP4 that may regulate the pathogenesis of HF.
|
29856483 |
2018 |
|
Liver diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Soluble CD222 has been found in higher concentrations in sera of liver disease patients.
|
29940770 |
2018 |
|
Meningoencephalitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study contributes to a deeper understanding of the molecular regulation of Mpr1 activity and may lead to the development of specific inhibitors that could be used to restrict fungal penetration of the CNS and thus prevent cryptococcal meningoencephalitis-related deaths.
|
30161190 |
2018 |
|
Multiple Myeloma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The urine CD222 levels were increased specifically in breast cancer and multiple myeloma.
|
29940770 |
2018 |
|
Myocardial Ischemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fifty patients with angina (65 ± 9 years of age) and 20 age-matched healthy control subjects underwent adenosine stress CMR (1.5- and 3-T) to assess left ventricular function, inducible ischemia (myocardial perfusion reserve index [MPRI]; myocardial blood flow [MBF]), and infarction (late gadolinium enhancement).
|
29495996 |
2018 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Compared to CM, which showed frequent mutations in known driver genes (BRAF 50.0%, NRAS 29.2%), MM displayed lower mutation frequencies (BRAF; 12.2%, p < 0.001, NRAS; 17.1%), and was significantly more enriched for triple wild-type (no mutations in BRAF, RAS, or NF1, 70.7% vs 25.0%, p < 0.001), IGF2R mutation (31.7% vs 6.3%, p = 0.002), and KIT mutation (9.8% vs 0%, p = 0.042).
|
30373548 |
2018 |
|
Choroid Plexus Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
BMI in the CPP group was associated with IGF-2(3580), IGF1R, and the combinations of [IGF-2(3580) + IGF2R], and [IGF-2(3580) + IGFBP-3].
|
30249230 |
2018 |