IGF2R, insulin like growth factor 2 receptor, 3482

N. diseases: 166; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE Loss of IGF2R indicates a poor prognosis and promotes cell proliferation and tumorigenesis in bladder cancer via AKT signaling pathway. 31847523 2020
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE Based on this work, we propose serum soluble CD222 as a general biomarker for tumorigenesis. 29940770 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE Mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) in carcinogenesis. 19646808 2010
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 AlteredExpression phenotype BEFREE However, whether or not decreased levels of functional M6P/IGF2R directly contribute to the process of carcinogenesis needs to be further verified by functional studies. 12149131 2002
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 GeneticVariation phenotype BEFREE These findings provide evidence that LOH at the M6P/IGF2R locus is a frequent event in adrenocortical tumors and support the hypothesis that it may function as a tumor suppressor gene in adrenocortical tumorigenesis. 11182753 2001
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE To investigate whether there was a common genetic mechanism of carcinogenesis for the three lesions, MSI status was assessed, TGFbetaRII, IGFIIR and BAX were analysed for mutations and protein expression of transforming growth factor beta1 (TGFbeta1) and p53 were studied using immunohistochemistry. 10855548 2000
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE Microsatellites within the coding region of the transforming growth factor beta receptor type II (RII) and insulin-like growth factor II receptor (IGF-IIR) genes were reported to be targets for mutation during the course of carcinogenesis in MI+ tumors. 9563904 1998
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE The high frequency of aberrant persistence of IGF2R imprinting in the kidneys of Wilms' tumor patients, which may be an embryonic feature, suggests that it is a predisposing factor in tumorigenesis. 9070652 1997
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.090 Biomarker phenotype BEFREE These results implicate abnormal IGFIIR-mediated growth control in carcinogenesis involving the endometrium, stomach, and colorectum but not the pancreas. 9157973 1997