Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis
0.050 GeneticVariation disease BEFREE Mannose 6-phosphate/insulin-like growth factor II receptor (M6P/IGF2R) tumor suppressor- gene mutation is an early event in human hepatocellular carcinoma (HCC) formation in the United States, but its role in hepatocarcinogenesis in Japan is unclear. 11981765 2002
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis
0.050 Biomarker disease BEFREE Although M6p/Igf2r, Apc, and p53 have been shown to be mutated in a variety of human hepatic proliferative diseases, our results indicate that aberrations in these genes may not be necessary for liver carcinogenesis in the rat. 10411141 1999
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis
0.050 GeneticVariation disease BEFREE Thus inactivation of the M6P/IGF2R gene because of genetic alteration does not appear to be essential for hepatocarcinogenesis in Japan. 10347113 1999
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis
0.050 AlteredExpression disease BEFREE M6P/IGF2R allele loss was also found in cirrhotic tissue of clonal origin adjacent to these dysplastic lesions and HCCs, demonstrating that M6P/IGF2R inactivation occurs early in liver carcinogenesis. 9294214 1997
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis
0.050 Biomarker disease BEFREE These mutations give rise to truncated receptor protein and significant amino acid substitutions, and provide evidence that the M6P/IGF2R gene functions as a tumour suppressor in human liver carcinogenesis. 7493029 1995