|
Malignant neoplasm of prostate
|
0.310 |
Therapeutic
|
disease |
CTD_human |
IGFBP-6 therefore might be involved in the direct effects of DES in androgen-independent prostate cancer.
|
15846301 |
2005 |
|
Malignant neoplasm of prostate
|
0.310 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor binding protein-6 inhibits prostate cancer cell proliferation: implication for anticancer effect of diethylstilbestrol in hormone refractory prostate cancer.
|
15846301 |
2005 |
|
Contact Dermatitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Contact hypersensitivity
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Genes specifically modulated in sensitized skins allow the detection of sensitizers in a reconstructed human skin model. Development of the SENS-IS assay.
|
25724174 |
2015 |
|
Respiratory Distress Syndrome, Adult
|
0.300 |
Biomarker
|
disease |
CTD_human |
MicroRNA and mRNA expression profiling in rat acute respiratory distress syndrome.
|
25070658 |
2014 |
|
Endometriosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Molecular evidence for differences in endometrium in severe versus mild endometriosis.
|
21063030 |
2011 |
|
Spontaneous abortion
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Abortion, Tubal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Early Pregnancy Loss
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Miscarriage
|
0.300 |
Biomarker
|
disease |
CTD_human |
Gene expression in cultured endometrium from women with different outcomes following IVF.
|
18539642 |
2008 |
|
Prostatic Neoplasms
|
0.300 |
Therapeutic
|
group |
CTD_human |
Insulin-like growth factor binding protein-6 inhibits prostate cancer cell proliferation: implication for anticancer effect of diethylstilbestrol in hormone refractory prostate cancer.
|
15846301 |
2005 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Finally, elevated expression of IGF-1R and IGF2 in gliomas associated with poor patient survival and tumor expression levels of IGFBP6 directly correlated with overall survival time in patients with GBM.
|
30231881 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Among these, IGFBP‑6 binds with high affinity and inhibits insulin growth factor‑2 (IGF‑2) to inhibit the growth of IGF‑2‑dependent tumors.
|
29039467 |
2017 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
IGFBP-6 showed significantly decreased expression in 170 out of 263 patients based on IHC data and this was associated with a larger tumor size (P<0.001) and poorly-differentiated adenocarcinoma (P=0.001), as well as with palliative gastrectomy (P=0.015).
|
28588703 |
2017 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
In addition, IGFBP-6 mRNA expression was associated with tumor invasion (tumor size) and the IGFBP-6 protein level was associated with nodal status.
|
27644646 |
2016 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Here, we report that hypoxia induced the expression of insulin-like growth factor binding protein-6 (IGFBP-6), a tumor repressor, in human and rodent vascular endothelial cells (VECs) via a hypoxia-inducible factor (HIF)-mediated mechanism.
|
21618524 |
2012 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Therefore, increased induction of IGFBP6 gene or protein expression in oral tumors could be regarded as a potential predictive marker of tumor sensitivity and could be used for prognostic purposes, since a significant correlation could be observed between increased induction of apoptotic cell death and elevated levels of IGFBP6 in these tumors.
|
18982452 |
2008 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
This is particularly significant since IGFBP-6 provides an attractive basis for therapy of IGF-II-dependent tumors.
|
15914054 |
2005 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
In small IGFBP-6-expressing xenografts where tumour development had apparently been arrested, haematoxylin--eosin and TUNEL staining revealed numerous apoptotic cells.
|
11874695 |
2002 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Among the four tumour types the expression of IGF-1R, IGF-2R and IGFBP-6 varied significantly.
|
10964166 |
2000 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The insulin-like growth factor binding protein 6 (IGFBP6), a direct inhibitor of insulin-like growth factor (IGF)-II, also exerts IGF-independent effects including tumor cell migration <i>in vitro</i>.
|
28572803 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
Additionally, decreased expression of IGFBP-6 was associated with stage T3/4a/4b disease and lymph node-positive metastasis (P<0.001).
|
28588703 |
2017 |
|
Neoplasm Metastasis
|
0.050 |
AlteredExpression
|
phenotype |
BEFREE |
IGFBP6 knockdown activated the GSK3β/β-catenin/cyclin D1 pathway and enhanced CNE2 tumor cell growth and metastasis in a mouse model.
|
27623076 |
2016 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
IGFBP-6 may be considered as a potential biomarker associated with lymphogenous metastasis and the metabolic syndrome in colorectal cancer.
|
27644646 |
2016 |