|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A case of hairy cell leukemia with CCND1-IGH@ translocation: indolent non-nodal mantle cell lymphoma revisited.
|
21677543 |
2011 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
Cloned IGH VDJ targets as tools for personalized minimal residual disease monitoring in mature lymphoid malignancies; a feasibility study in mantle cell lymphoma by the Groupe Ouest Est d'Etude des Leucémies et Autres Maladies du Sang.
|
22626453 |
2012 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Consistently, PI3Kδ inhibitors enhanced AID expression and translocation frequency to IGH and AID off-target sites in human chronic lymphocytic leukaemia and mantle cell lymphoma cell lines, and patients treated with idelalisib, but not ibrutinib, showed increased somatic hypermutation in AID off-targets.
|
28199309 |
2017 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Detection of t(12;14)(p13;q32) in a patient with IGH-CCND1 negative mantle cell lymphoma resembling ultra-high risk chronic lymphocytic leukemia.
|
26261659 |
2015 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Five M(+), IGH(-) cases were found, including two cases of follicular lymphoma (FL), one case of diffuse large B cell lymphoma, and two cases of mantle cell lymphoma.
|
19329714 |
2009 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the complemented analysis using 24-color FISH, chromosomal whole paints, telomeric probes and locus specific identifiers enabled us to characterize complex and/or masked IGH translocations in follicular lymphomas and mantle cell lymphomas and to identify all the chromosomal partners involved in IGH rearrangements in diffuse large B-cell lymphomas.
|
18000389 |
2007 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the complemented analysis using Multi-FISH and/or chromosomal whole paint enabled the characterization of complex IGH translocations in follicular lymphomas and mantle cell lymphomas and the identification of all the chromosomal partners involved in the IGH rearrangement in diffuse large B-cell lymphomas.
|
16101124 |
2005 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 14 CD23 negative cases IGH/BCL1 FISH detected t(11;14) and was confirmed to be mantle cell lymphoma.
|
16487171 |
2006 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In both cases, nucleotide sequence analysis revealed common clone-specific IgH gene rearrangements in MCL and subsequent MCL-BV.
|
10564390 |
1999 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this case we present an old man with concomitant mantle cell lymphoma and large granular lymphocytic leukemia diagnosed by the morphology of the bone marrow aspiration, immunophenotyping of the peripheral blood by flow cytometry detecting the increased CD3+CD4-CD8+ cells, immunohistochemical studies of lymph node showed cyclinD1+, chromosome analysis by fluorescence in situ hybridization (FISH) showed t(11,14), positive results of IGH and TCR rearrangement studies.
|
26045870 |
2015 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
It is widely acknowledged that FISH is the most consistently useful test to identify the juxtaposition of the CCND1 and IGH genes in mantle cell lymphoma and is regarded as the 'gold standard'.
|
16373229 |
2005 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data show that mantle cell lymphoma cell lines resemble the IGHV and IGLV usage of mantle cell lymphoma, and foster the hypothesis that light chain stereotypy might be under-recognized.
|
23245212 |
2013 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymerase chain reaction (PCR) analysis for rearranged immunoglobulin heavy chain (IgH) genes showed a dominant band identical in size in microdissected tumor cells of the follicle center cell and mantle cell lymphomas.
|
10452515 |
1999 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(11;14)(q13;q32) CCND1-IGH is typically associated with mantle cell lymphoma or a subset of plasma cell myeloma and is exceedingly rare in myeloid neoplasm.
|
27810077 |
2016 |
|
Malignant lymphoma, lymphocytic, intermediate differentiation, diffuse
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We report a case of leukemic mantle cell lymphoma of the blastoid variant with complex chromosomal rearrangements leading to the recombination of BCL1 from 11q13 and IGH from 14q32.
|
16527613 |
2006 |