|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated.
|
21227398 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The t(14;18)(q32;q21) involving the IGH and the MALT1 gene has previously been described in PCMZL, whereas the t(14;18)(q32;q21) IGH/BCL2 seems to be restricted to follicular lymphoma and diffuse large B-cell lymphoma.
|
17519619 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH.
|
25311808 |
2014 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comparative analysis between RQ-PCR and digital droplet PCR of BCL2/IGH gene rearrangement in the peripheral blood and bone marrow of early stage follicular lymphoma.
|
28419517 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR).
|
31385309 |
2020 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of patients with follicular lymphoma (FL) harbor the t(14;18)(q32;q21) IGH/BCL2 gene rearrangement that leads to the overexpression of BCL2 protein, approximately 20% of FL cases lack t(14;18)(q32;q21).
|
31789408 |
2020 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
[BCL-2/IgH translocation in peripheral blood cells of healthy Chinese individuals of Han nationality located in Zhejiang area].
|
16215945 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy chain (IgH) gene.
|
17964648 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The translocation t(14;18) between the BCL-2 oncogene and the Ig heavy chain (IgH) gene provides the molecular basis for the development of follicular lymphomas.
|
8461469 |
1993 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The FL with signet-ring cell morphology (1/5) tends to lack IGH/BCL2 translocation, and an extended immunohistochemical study is recommended for correct diagnosis and classification of SRCL.
|
28038709 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Translocation t(14;18)(q32;q21) and/or BCL-2-IGH gene rearrangements were the genomic alterations most frequently observed: 50% of S-DLBCL and 30% of dn-DLBCL.
|
16519699 |
2006 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements.
|
18272816 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PCR analysis of the HS detected a monoclonal rearrangement of the IGH gene and FISH analysis revealed IGH/BCL2 fusion, a genetic hallmark for FL.
|
20331331 |
2010 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combination of different primer sets for the detection of IgH gene rearrangement and bcl-2/JH is most desirable for follicular lymphomas.
|
8619747 |
1996 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphomas characteristically carry t(14;18)(q32;q21) which results in IGH-BCL-2 fusion.
|
18656237 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy-chain (IgH) gene, which is the molecular hallmark of FL, whereas a subset of cases harbor translocations involving the BCL6 gene locus.
|
22968395 |
2012 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL.
|
20952062 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B-cell lymphomas, mainly follicular lymphomas, carrying a t(14;18) chromosomal translocation associated with rearrangement of the BCL2 gene and the immunoglobulin heavy chain (IGH) gene, share many similarities with germinal center B cells in the secondary lymphoid follicle.
|
7734714 |
1995 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH.
|
29310838 |
2018 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Interphase fluorescence in situ hybridization is more sensitive than BIOMED-2 polymerase chain reaction protocol in detecting IGH-BCL2 rearrangement in both fixed and frozen lymph node with follicular lymphoma.
|
17134735 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration.
|
2106002 |
1990 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the high-grade B-cell component alone.
|
29793519 |
2018 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The t(14;18) (q32;q21) translocation, which juxtaposes the bcl-2 oncogene on chromosome 18 and the JH segment of the immunoglobulin heavy chain (IgH) genes on chromosome 14, is found frequently in follicular lymphomas.
|
10193514 |
1998 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction (PCR) protocols have been developed to detect the t(14;18) translocation, which juxtaposes the bcl-2 proto-oncogene to the Ig heavy-chain (IgH) gene in 85% of follicular lymphomas and monoclonal rearrangements of the IgH gene in B-cell NHL that lack bcl-2 rearrangements.
|
8111048 |
1994 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
PCR analysis demonstrated the presence of on IGH-BCL2 rearrangement with a breakpoint in the minor cluster region (mcr) confirming the t(14;18) characteristic for follicular lymphoma.
|
8019967 |
1994 |