IGH, immunoglobulin heavy locus, 3492

N. diseases: 238; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated. 21227398 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The t(14;18)(q32;q21) involving the IGH and the MALT1 gene has previously been described in PCMZL, whereas the t(14;18)(q32;q21) IGH/BCL2 seems to be restricted to follicular lymphoma and diffuse large B-cell lymphoma. 17519619 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH. 25311808 2014
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Comparative analysis between RQ-PCR and digital droplet PCR of BCL2/IGH gene rearrangement in the peripheral blood and bone marrow of early stage follicular lymphoma. 28419517 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR). 31385309 2020
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Although the majority of patients with follicular lymphoma (FL) harbor the t(14;18)(q32;q21) IGH/BCL2 gene rearrangement that leads to the overexpression of BCL2 protein, approximately 20% of FL cases lack t(14;18)(q32;q21). 31789408 2020
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE We performed interphase fluorescence in situ hybridization (FISH) analysis to detect Bcl-2/IgH, Bcl-6 gene rearrangement, Bcl-2 gene amplification, and the cyclinD1/IgH gene in formalin-fixed paraffin embedded specimens from our FL archives. 15723651 2005
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The sequence analysis of the IgH gene revealed both of cells originated from the same clone, showing that the aggressive BL-like tumor originated from the FL-like clones simultaneously found in the bone marrow. 21184290 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE B-cell clonality was detected by combined use of the IGH and IGK multiplex PCR assays in all 260 definitive cases of B-cell chronic lymphocytic leukemia (n=56), mantle cell lymphoma (n=54), marginal zone lymphoma (n=41) and follicular lymphoma (n=109). 17170731 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy chain (IgH) gene. 17964648 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. 22431543 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The translocation t(14;18) between the BCL-2 oncogene and the Ig heavy chain (IgH) gene provides the molecular basis for the development of follicular lymphomas. 8461469 1993
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The FL with signet-ring cell morphology (1/5) tends to lack IGH/BCL2 translocation, and an extended immunohistochemical study is recommended for correct diagnosis and classification of SRCL. 28038709 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Translocation t(14;18)(q32;q21) and/or BCL-2-IGH gene rearrangements were the genomic alterations most frequently observed: 50% of S-DLBCL and 30% of dn-DLBCL. 16519699 2006
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Genealogic analysis based on somatic hypermutation of the rearranged IGH genes of both FL and PBL suggests that transformation of the FL to PBL occurred most likely by divergent evolution from a common progenitor cell rather than direct evolution from the FL clone. 21088162 2010
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 AlteredExpression disease BEFREE This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular lymphoma histologic grade in 255 follicular lymphoma patients who were treated with rituximab-containing therapy. 23916290 2013
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Polymerase chain reaction (PCR) amplification, cloning, and sequencing of the junctional region of the hybrid bcl-2/IgH genes showed identical nucleotide sequences in multiple biopsy specimens of FL that did not show morphologic transformation. 8916960 1996
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In conclusion, pretreatment quantity of BCL2/IGH in PB or BM seems to mirror the extent of disease and can provide an auxiliary prognostic parameter in FL. 22381682 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Follicular lymphoma (FL) is characterized genetically by a significant intraclonal diversity of rearranged immunoglobulin heavy chain (IGH) genes and a substantial cell migration activity (follicular trafficking). 28640838 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The IGHV gene repertoire was remarkably biased in FL. 31209206 2019
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. 18272816 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The IGH gene rearrangement was mainly found in lymphoplasmacytoid lymphomas and follicular lymphomas. 29100365 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE PCR analysis of the HS detected a monoclonal rearrangement of the IGH gene and FISH analysis revealed IGH/BCL2 fusion, a genetic hallmark for FL. 20331331 2010
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The combination of different primer sets for the detection of IgH gene rearrangement and bcl-2/JH is most desirable for follicular lymphomas. 8619747 1996