|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphomas characteristically carry t(14;18)(q32;q21) which results in IGH-BCL-2 fusion.
|
18656237 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphomas in the other group lacked IGH-BCL2 and Bcl-2 expression, were often of WHO grade 3 and were often CD10-negative, similar to the minority of follicular lymphomas previously described that are Bcl-2-negative and are often encountered at other extranodal sites.
|
18830125 |
2009 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Follicular lymphoma (FL) is characterized genetically by a significant intraclonal diversity of rearranged immunoglobulin heavy chain (IGH) genes and a substantial cell migration activity (follicular trafficking).
|
28640838 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Follicular lymphoma (FL) is characterized in a significant proportion of cases by the t(14;18) chromosomal translocation, which results in the juxtaposition of the oncogene bcl-2 to the joining region of the immunoglobulin heavy chain (IgH) gene.
|
9160682 |
1997 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
IGH PCR alone is not good enough for BMTB assessment, especially in FL.
|
19329714 |
2009 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IGHV mutation analysis showed that all FL-B-LBL pairs harbored identical or near-identical somatic mutations.
|
27750045 |
2016 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH.
|
29310838 |
2018 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL.
|
20952062 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Although the majority of patients with follicular lymphoma (FL) harbor the t(14;18)(q32;q21) IGH/BCL2 gene rearrangement that leads to the overexpression of BCL2 protein, approximately 20% of FL cases lack t(14;18)(q32;q21).
|
31789408 |
2020 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
B-cell clonality was detected by combined use of the IGH and IGK multiplex PCR assays in all 260 definitive cases of B-cell chronic lymphocytic leukemia (n=56), mantle cell lymphoma (n=54), marginal zone lymphoma (n=41) and follicular lymphoma (n=109).
|
17170731 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B-cell lymphomas, mainly follicular lymphomas, carrying a t(14;18) chromosomal translocation associated with rearrangement of the BCL2 gene and the immunoglobulin heavy chain (IGH) gene, share many similarities with germinal center B cells in the secondary lymphoid follicle.
|
7734714 |
1995 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Bcl-2/IgH gene rearrangement is detected in 80-90% of follicular lymphomas in Western countries.
|
18665753 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comparative analysis between RQ-PCR and digital droplet PCR of BCL2/IGH gene rearrangement in the peripheral blood and bone marrow of early stage follicular lymphoma.
|
28419517 |
2017 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic analysis and targeted next-generation sequencing of both FL and HS tumors identified common genomic alterations such as IGH-BCL2 rearrangement, CREBBP and KMT2D, and aberrations of chromosomes 9q and 19q.
|
31807922 |
2019 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens.
|
21497287 |
2011 |
|
Lymphoma, Follicular
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the high-grade B-cell component alone.
|
29793519 |
2018 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Genealogic analysis based on somatic hypermutation of the rearranged IGH genes of both FL and PBL suggests that transformation of the FL to PBL occurred most likely by divergent evolution from a common progenitor cell rather than direct evolution from the FL clone.
|
21088162 |
2010 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, by examination of immunoglobulin H (IgH) receptor rearrangement and comparison of medullar and nodular lymphoma sites, diagnostic reliability was improved.
|
18425348 |
2008 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, CD10-MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1- typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification).
|
17138820 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the complemented analysis using 24-color FISH, chromosomal whole paints, telomeric probes and locus specific identifiers enabled us to characterize complex and/or masked IGH translocations in follicular lymphomas and mantle cell lymphomas and to identify all the chromosomal partners involved in IGH rearrangements in diffuse large B-cell lymphomas.
|
18000389 |
2007 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the complemented analysis using Multi-FISH and/or chromosomal whole paint enabled the characterization of complex IGH translocations in follicular lymphomas and mantle cell lymphomas and the identification of all the chromosomal partners involved in the IGH rearrangement in diffuse large B-cell lymphomas.
|
16101124 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results indicate that analysis of IGHV gene usage might aid in predicting prognosis for FL patients.
|
25900812 |
2015 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, pretreatment quantity of BCL2/IGH in PB or BM seems to mirror the extent of disease and can provide an auxiliary prognostic parameter in FL.
|
22381682 |
2012 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we present the first examples of molecularly verified IgH-associated translocations in HL, which also show that BCL2/IGH or CCND1/IGH translocations can represent early steps in the pathogenesis of composite HL/FL or HL/MCL.
|
15973455 |
2005 |
|
Lymphoma, Follicular
|
0.400 |
Biomarker
|
disease |
BEFREE |
In Taiwan, FL3A tumours were more closely related to FL3B tumours than to LG tumours, and a literature review showed that the frequency of t(14;18)/IGH-BCL2 in FL in Taiwan is among the lowest in the world.
|
23631722 |
2013 |