IGH, immunoglobulin heavy locus, 3492

N. diseases: 238; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE We have designed a multiplex PCR, which allows for fast and high throughput demonstration of the BCL-1/IGH and BCL-2/IGH fusion DNA observed primarily in mantle cell- and follicular non-Hodgkin's lymphoma (NHL). 17438702 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy chain (IgH) gene. 17964648 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE We studied 8 patients with both FL and H/DC neoplasms using immunohistochemistry, fluorescence in situ hybridization (FISH) for t(14;18), and polymerase chain reaction (PCR)/sequencing of BCL2 and IGH rearrangements. 18272816 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Follicular lymphomas characteristically carry t(14;18)(q32;q21) which results in IGH-BCL-2 fusion. 18656237 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Bcl-2/IgH gene rearrangement is detected in 80-90% of follicular lymphomas in Western countries. 18665753 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Here, by examination of immunoglobulin H (IgH) receptor rearrangement and comparison of medullar and nodular lymphoma sites, diagnostic reliability was improved. 18425348 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Follicular lymphomas in the other group lacked IGH-BCL2 and Bcl-2 expression, were often of WHO grade 3 and were often CD10-negative, similar to the minority of follicular lymphomas previously described that are Bcl-2-negative and are often encountered at other extranodal sites. 18830125 2009
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE IGH PCR alone is not good enough for BMTB assessment, especially in FL. 19329714 2009
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Genealogic analysis based on somatic hypermutation of the rearranged IGH genes of both FL and PBL suggests that transformation of the FL to PBL occurred most likely by divergent evolution from a common progenitor cell rather than direct evolution from the FL clone. 21088162 2010
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE PCR analysis of the HS detected a monoclonal rearrangement of the IGH gene and FISH analysis revealed IGH/BCL2 fusion, a genetic hallmark for FL. 20331331 2010
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated. 21227398 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The sequence analysis of the IgH gene revealed both of cells originated from the same clone, showing that the aggressive BL-like tumor originated from the FL-like clones simultaneously found in the bone marrow. 21184290 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens. 21497287 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE According to our results, FISH is the best technique to define variant rearrangements of IGH/BCL2 genes and is important to detect it in cases with non-conclusive FL characteristics to avoid misdiagnosis with other NHL. 20952062 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas. 21790530 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. 22431543 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In conclusion, pretreatment quantity of BCL2/IGH in PB or BM seems to mirror the extent of disease and can provide an auxiliary prognostic parameter in FL. 22381682 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy-chain (IgH) gene, which is the molecular hallmark of FL, whereas a subset of cases harbor translocations involving the BCL6 gene locus. 22968395 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 FusionGene disease ORPHANET In the present study, 5/6 cases in which FISH was successful had an IGH/BCL2 fusion as would result from the t(14; 18)(q32; q21) translocation commonly seen in FL of extraoral sites. 23953419 2013
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 AlteredExpression disease BEFREE This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular lymphoma histologic grade in 255 follicular lymphoma patients who were treated with rituximab-containing therapy. 23916290 2013
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In Taiwan, FL3A tumours were more closely related to FL3B tumours than to LG tumours, and a literature review showed that the frequency of t(14;18)/IGH-BCL2 in FL in Taiwan is among the lowest in the world. 23631722 2013
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH. 25311808 2014
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In conclusion, our results indicate that analysis of IGHV gene usage might aid in predicting prognosis for FL patients. 25900812 2015
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Of these, t(14;18)(q32;q21) results in juxtaposition of the IGH gene on chromosome 14 and the BCL2 gene on chromosome 18, leading to the overexpression of BCL2 anti-apoptotic protein, which plays a critical role in the development of follicular lymphoma (FL). 26115875 2015
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE IGHV mutation analysis showed that all FL-B-LBL pairs harbored identical or near-identical somatic mutations. 27750045 2016