IGH, immunoglobulin heavy locus, 3492

N. diseases: 238; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. 22431543 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 FusionGene disease ORPHANET In the present study, 5/6 cases in which FISH was successful had an IGH/BCL2 fusion as would result from the t(14; 18)(q32; q21) translocation commonly seen in FL of extraoral sites. 23953419 2013
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Interphase fluorescence in situ hybridization is more sensitive than BIOMED-2 polymerase chain reaction protocol in detecting IGH-BCL2 rearrangement in both fixed and frozen lymph node with follicular lymphoma. 17134735 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH. 25311808 2014
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Molecular cytogenetics showed IGH/BCL2 fusion in the follicular lymphoma and amplification of IGH gene or trisomy/tetrasomy 14 in the PTCL. 29217426 2018
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Molecular diagnostic laboratories face such difficulties with the BCL2-IGH translocation in follicular lymphoma and with internal tandem duplication mutation of the FLT3 gene in leukemia, where breakpoints are widely distributed, mutations may be multiple, signal strength is low, and background noise is elevated. 21227398 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration. 2106002 1990
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Of these, t(14;18)(q32;q21) results in juxtaposition of the IGH gene on chromosome 14 and the BCL2 gene on chromosome 18, leading to the overexpression of BCL2 anti-apoptotic protein, which plays a critical role in the development of follicular lymphoma (FL). 26115875 2015
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas. 21790530 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE PCR analysis demonstrated the presence of on IGH-BCL2 rearrangement with a breakpoint in the minor cluster region (mcr) confirming the t(14;18) characteristic for follicular lymphoma. 8019967 1994
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE PCR analysis of the HS detected a monoclonal rearrangement of the IGH gene and FISH analysis revealed IGH/BCL2 fusion, a genetic hallmark for FL. 20331331 2010
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Polymerase chain reaction (PCR) amplification, cloning, and sequencing of the junctional region of the hybrid bcl-2/IgH genes showed identical nucleotide sequences in multiple biopsy specimens of FL that did not show morphologic transformation. 8916960 1996
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Polymerase chain reaction (PCR) protocols have been developed to detect the t(14;18) translocation, which juxtaposes the bcl-2 proto-oncogene to the Ig heavy-chain (IgH) gene in 85% of follicular lymphomas and monoclonal rearrangements of the IgH gene in B-cell NHL that lack bcl-2 rearrangements. 8111048 1994
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR). 31385309 2020
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The FL with signet-ring cell morphology (1/5) tends to lack IGH/BCL2 translocation, and an extended immunohistochemical study is recommended for correct diagnosis and classification of SRCL. 28038709 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The IGH gene rearrangement was mainly found in lymphoplasmacytoid lymphomas and follicular lymphomas. 29100365 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The IGHV gene repertoire was remarkably biased in FL. 31209206 2019
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The t(14;18)(q32;q21) associated with follicular lymphoma juxtaposes a portion of BCL-2 (18q21) and IGH(14q32); the result is bcl-2 overexpression. 12953811 2003
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The t(14;18)(q32;q21) involving the IGH and the MALT1 gene has previously been described in PCMZL, whereas the t(14;18)(q32;q21) IGH/BCL2 seems to be restricted to follicular lymphoma and diffuse large B-cell lymphoma. 17519619 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The combination of different primer sets for the detection of IgH gene rearrangement and bcl-2/JH is most desirable for follicular lymphomas. 8619747 1996
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy chain (IgH) gene. 17964648 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The most common genetic aberration in follicular lymphoma (FL) is the t(14;18)(q32;q21) translocation that juxtaposes the antiapoptotic BCL2 gene with the promoter of the immunoglobulin heavy-chain (IgH) gene, which is the molecular hallmark of FL, whereas a subset of cases harbor translocations involving the BCL6 gene locus. 22968395 2012
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The particular translocation in follicular lymphomas (FLs) is a t(14;18)(q32;q21), recombining the immunoglobulin heavy chain (IgH) gene on chromosome 14 with the B-cell leukemia/lymphoma 2 (BCL2) gene on chromosome 18. 15700138 2005
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The sequence analysis of the IgH gene revealed both of cells originated from the same clone, showing that the aggressive BL-like tumor originated from the FL-like clones simultaneously found in the bone marrow. 21184290 2011