IGH, immunoglobulin heavy locus, 3492

N. diseases: 238; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The t(14;18) or IGH-BCL2 fusion was detected in 83% (20/24) of follicular lymphomas and in 57% (12/21) of diffuse large B-cell lymphomas (DLBCL). 12742158 2003
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The t(14;18)(q32;q21) associated with follicular lymphoma juxtaposes a portion of BCL-2 (18q21) and IGH(14q32); the result is bcl-2 overexpression. 12953811 2003
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The t(14;18) (q32;q21) translocation, which juxtaposes the bcl-2 oncogene on chromosome 18 and the JH segment of the immunoglobulin heavy chain (IgH) genes on chromosome 14, is found frequently in follicular lymphomas. 10193514 1998
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Follicular lymphoma (FL) is characterized in a significant proportion of cases by the t(14;18) chromosomal translocation, which results in the juxtaposition of the oncogene bcl-2 to the joining region of the immunoglobulin heavy chain (IgH) gene. 9160682 1997
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Polymerase chain reaction (PCR) amplification, cloning, and sequencing of the junctional region of the hybrid bcl-2/IgH genes showed identical nucleotide sequences in multiple biopsy specimens of FL that did not show morphologic transformation. 8916960 1996
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The combination of different primer sets for the detection of IgH gene rearrangement and bcl-2/JH is most desirable for follicular lymphomas. 8619747 1996
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE B-cell lymphomas, mainly follicular lymphomas, carrying a t(14;18) chromosomal translocation associated with rearrangement of the BCL2 gene and the immunoglobulin heavy chain (IGH) gene, share many similarities with germinal center B cells in the secondary lymphoid follicle. 7734714 1995
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Polymerase chain reaction (PCR) protocols have been developed to detect the t(14;18) translocation, which juxtaposes the bcl-2 proto-oncogene to the Ig heavy-chain (IgH) gene in 85% of follicular lymphomas and monoclonal rearrangements of the IgH gene in B-cell NHL that lack bcl-2 rearrangements. 8111048 1994
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE PCR analysis demonstrated the presence of on IGH-BCL2 rearrangement with a breakpoint in the minor cluster region (mcr) confirming the t(14;18) characteristic for follicular lymphoma. 8019967 1994
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The translocation t(14;18) between the BCL-2 oncogene and the Ig heavy chain (IgH) gene provides the molecular basis for the development of follicular lymphomas. 8461469 1993
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The translocation t(14;18)(q32;q21) occurs in 70% of follicular lymphomas and places the BCL2 proto-oncogene, normally located at 18q21, under the control of the immunoglobulin heavy chain (IgH) gene at 14q32. 1342952 1992
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Most of human follicular lymphomas possess the t(14;18) chromosome translocation that juxtaposes the IgH gene to the 3' region of bcl-2 in a head-to-tail configuration. 2106002 1990