IGH, immunoglobulin heavy locus, 3492

N. diseases: 238; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens. 21497287 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE However, the complemented analysis using 24-color FISH, chromosomal whole paints, telomeric probes and locus specific identifiers enabled us to characterize complex and/or masked IGH translocations in follicular lymphomas and mantle cell lymphomas and to identify all the chromosomal partners involved in IGH rearrangements in diffuse large B-cell lymphomas. 18000389 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In conclusion, our results indicate that analysis of IGHV gene usage might aid in predicting prognosis for FL patients. 25900812 2015
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas. 21790530 2011
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE However, CD10-MUM1+ FLs were encountered frequently in the elderly compared with CD10+MUM1- typical FLs (67.0 versus 58.7 years, P < .01), showed high grade (grade 3A or 3B) morphology (91% versus 17%, P < .001), diffuse proliferation (59% vs 19%, P < .001), and lacked BCL2/IGH translocation (5% versus 92.5%, P < .001), which is the most characteristic aberration in FL, and 88% showed BCL6 gene abnormalities (translocation or amplification). 17138820 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE However, the complemented analysis using Multi-FISH and/or chromosomal whole paint enabled the characterization of complex IGH translocations in follicular lymphomas and mantle cell lymphomas and the identification of all the chromosomal partners involved in the IGH rearrangement in diffuse large B-cell lymphomas. 16101124 2005
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE We have designed a multiplex PCR, which allows for fast and high throughput demonstration of the BCL-1/IGH and BCL-2/IGH fusion DNA observed primarily in mantle cell- and follicular non-Hodgkin's lymphoma (NHL). 17438702 2007
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE In conclusion, we present the first examples of molecularly verified IgH-associated translocations in HL, which also show that BCL2/IGH or CCND1/IGH translocations can represent early steps in the pathogenesis of composite HL/FL or HL/MCL. 15973455 2005
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Here, by examination of immunoglobulin H (IgH) receptor rearrangement and comparison of medullar and nodular lymphoma sites, diagnostic reliability was improved. 18425348 2008
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE IGH PCR alone is not good enough for BMTB assessment, especially in FL. 19329714 2009
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 AlteredExpression disease BEFREE This study aimed to determine the correlations of 7 histopathologic prognostic indicators of follicular lymphoma (follicular lymphoma grade, CD10 expression, Bcl-2 expression, IGH/BCL2 fusion, diffuse area, fibrosis, and marginal zone differentiation) with progression-free survival, overall survival, and follicular lymphoma histologic grade in 255 follicular lymphoma patients who were treated with rituximab-containing therapy. 23916290 2013
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 FusionGene disease ORPHANET In the present study, 5/6 cases in which FISH was successful had an IGH/BCL2 fusion as would result from the t(14; 18)(q32; q21) translocation commonly seen in FL of extraoral sites. 23953419 2013