Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Patients demonstrating a terminal deoxynucleotidyl transferase (TdT)-positive precursor B cell phenotype with IGH-MYC rearrangement have been reported to be molecularly distinct from BL and closer to B-ALL/LBL.
|
31705772 |
2020 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Thus, the capacity of Tat to spontaneously penetrate B-cells could be sufficient to favor the occurrence of MYC-IGH oncogenic rearrangements during erroneous repair, a plausible cause for the increased incidence of Burkitt lymphoma in the HIV-infected population.
|
30701532 |
2019 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Cryptic insertion of <i>MYC</i> exons 2 and 3 into the IGH locus detected by whole genome sequencing in a case of MYC-negative Burkitt lymphoma.
|
31073073 |
2019 |
Burkitt Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed.
|
28515100 |
2017 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We performed a polymerase chain reaction analysis of three regions of the VDJ junction of the immunoglobulin heavy chain (IGH) gene and compared the clonality of the first and second BL lesions, which were found to be clonally distinct.
|
25555480 |
2015 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal translocation t(8;14)(q24;q32) with juxtaposition of MYC to enhancer elements in the immunoglobulin heavy chain (IGH) gene locus is the genetic hallmark of the majority of Burkitt lymphoma and a subset of Diffuse large B-cell lymphoma patients.
|
23673335 |
2013 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A high Ki-67 proliferation index and positive bcl-2 staining (on cytospin slides or cell block material) of cases not conforming to typical Burkitt lymphoma morphology should prompt FISH analysis for c-MYC and/or IGH-BCL2 rearrangements to identify DHL, particularly if tissue biopsy is not expected.
|
21560252 |
2011 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have molecularly characterized the recently established Burkitt lymphoma cell line BLUE-1 that carries a t(6;20)(q15;q11.2) rearrangement in addition to the typical t(8;14) with MYC-IGH fusion.
|
21412927 |
2011 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
|
20118770 |
2010 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The chromosomal translocation t(8;14) is the hallmark of Burkitt's-lymphoma (BL) and fuses the proto-oncogene c-MYC to the IGH locus.
|
17541401 |
2007 |
Burkitt Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IGH switch breakpoints in Burkitt lymphoma: exclusive involvement of noncanonical class switch recombination.
|
16736499 |
2006 |
Burkitt Lymphoma
|
0.400 |
SomaticCausalMutation
|
disease |
ORPHANET |
Presence of more than two rearranged immunoglobulin heavy-chain genes in adult precursor B-cell acute lymphoblastic leukemia.
|
1554798 |
1992 |
Burkitt Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The DNA sequence of the third-complementarity-determining region (CDRIII) of the immunoglobulin heavy chain (IgH) gene in a case of Burkitt's lymphoma was determined by polymerase chain reaction (PCR) using template DNA extracted from a smear stored at room temperature for more than one year.
|
1908851 |
1991 |