|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
In addition, the presence and load of somatic hypermutation (SHM) within the rearranged IG heavy variable (IGHV) gene occurring as during B-cell development of germinal center and post-germinal center lymphomas may hamper appropriate primer binding leading to false-negative results.
|
30779036 |
2019 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
IGH@ proto-oncogene translocation is a common oncogenic event in lymphoid lineage cancers such as B-ALL, lymphoma and multiple myeloma.
|
31243274 |
2019 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
In the present study, we assessed by FISH whether exposure to low concentrations (0.1 μm, 72 hours) of permethrin and malathion induce aberrations in KMT2A and IGH genes, which are involved in the etiology of leukemia and lymphoma.
|
29741206 |
2018 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
To explore the relationship between IgH gene rearrangement and orbital MALT (mucose-associated lymphoid tissue) lymphoma removal operation prognosis, and to quantify the effect of IgH gene rearrangement on primary orbital MALT lymphoma prognosis.
|
28678330 |
2017 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Identification of IgH gene rearrangement and immunophenotype in an animal model of Epstein-Barr virus-associated lymphomas.
|
26991077 |
2016 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Specifically, the diagnosis of a relapsed DLBCL with acquisition of IGH-CCND1 was rendered for case 1, molecularly confirmed by the detection of identical monoclonal IGH rearrangements between the initial diagnostic DLBCL and relapse lymphoma.
|
25596256 |
2015 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
IGH@ evaluation of follow-up biopsies for these cases were nonclonal (7) or clonal, but with a different clone from the prior biopsy (1); follow-up of the 8 patients showed no evidence of lymphoma (mean, 37.8 mo).
|
24897069 |
2014 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The BIOMED-2 protocols were used to determine the clonality of IGH gene rearrangements in patients with lymphoma.
|
25481017 |
2014 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas.
|
22944768 |
2013 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
In patients with B-cell chronic lymphocytic leukemia, both flow-cytometry as well as RQ-PCR are equally suitable for MRD assessment as long as a sensitivity of ≤10(-4) shall be achieved.MRD diagnostics targeting the IgH gene is complex and requires extensive knowledge and experience because the junctional regions of each lymphoma have to be identified before the patient-specific RQ-PCR assays can be designed for MRD monitoring.
|
23296964 |
2013 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Both primary breast lymphoma and lymphoma with concurrent BCL2-IGH and MYC translocations are rare and are primarily seen in adult patients.
|
21491965 |
2012 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
FISH screening of a population-based cohort of B-cell lymphomas from a prospective trial for the treatment of lymphoma in childhood (BFM-NHL) identified additionally a follicular lymphoma Grade 3/diffuse large B-cell lymphoma with IGH-CBFA2T3/ACSF3 juxtaposition.
|
22420028 |
2012 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Patients with neoplasms characterized by extra MYC signals plus IGH@BCL2 (n=6) or MYC rearrangement with extra BCL2 signals (n=2) had overall survival ranging from 1.7 to 49 months, similar to patients with MYC/BCL2 lymphomas.
|
22002575 |
2012 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas.
|
21790530 |
2011 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
Overall our findings demonstrate that C. psittaci-negative ocular adnexal EMZL exhibit biased usage of IGHV families and genes with evidence for intraclonal heterogeneity and antigen selection in multiple tumors, implicating B-cell receptor-mediated antigen stimulation in the pathogenesis of these lymphomas.
|
22216179 |
2011 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Two showed an additional IGH-CCND1/t(11;14)(q13;q32) as fourth genetic event (according to research of the Mitelman database, the first reports on four genetic hits in lymphomas).
|
20960563 |
2011 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Therefore, current investigations using melting curve analysis are being developed 1213.In this study, three different techniques were compared to evaluate the suitability of LightCycler PCR with HRM as the clonal diagnostic tool for IgH gene rearrangement in B-cell non-Hogdkin lymphoma, i.e. thermocycler PCR followed by heteroduplex analysis and PAGE, GeneScan analysis and LightCycler PCR with HRM.
|
20482846 |
2010 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
LHGDN |
Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas.
|
18538438 |
2008 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
The heterogeneous representation of IGHV genes in HIV-NHL may be related to specific pathways of antigen stimulation, or to differences in host's immune dysregulation and lymphoma histogenesis.
|
18556404 |
2008 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We have comprehensively investigated the incidence and clinical significance of lymphoma-associated chromosomal translocations, particularly those involving the immunoglobulin heavy chain (IGH) gene locus, in a large series of gastric DLBCL.
|
18445693 |
2008 |
|
Lymphoma
|
0.200 |
AlteredExpression
|
group |
BEFREE |
A related issue, relevant not only to lymphoma development but also to normal controls on IGH gene expression, is the stage, during B lymphocyte development, at which the 3'RR is capable of activating MYC expression.
|
17639584 |
2007 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Thus, the molecular detection of a clonal rearrangement of the IGH gene may support the diagnosis of a malignant lymphoma infiltrating the bone marrow.
|
17560629 |
2007 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
A single-tube multiplex PCR targeted IGH and lymphoma-specific translocations in DNA extracted from 180 frozen lymphoid tissues and DNA bound to FTA cards from 192 fresh tissues and 137 aspirates.
|
17378729 |
2007 |
|
Lymphoma
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymerase chain reaction (PCR)-based analysis, employed for detecting immunoglobulin heavy chain (IgH) gene rearrangements, has become a diagnostic tool widely used in the investigation of B-cell lymphomas, but the overall sensitivity of these methods does not exceed 80%, notably in germinal center (GC) and post-GC B-cell origin lymphomas.
|
16677778 |
2006 |
|
Lymphoma
|
0.200 |
Biomarker
|
group |
BEFREE |
In addition to IgH gene rearrangement, C. pneumoniae DNA was detected in the lymphoma.
|
16765702 |
2006 |