B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our data, together with from those from the literature, confirmed the cutoff value of 2% to define the mutational status of IGHV gene and suggest that FCR/BR are good first-line treatment strategies for M-IGHV patients, whereas U-IGHV patients should be managed with B-cell receptor and/or B-cell lymphoma 2 (BCL2) inhibitors.
|
31371221 |
2019 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
ENKTCL with both CD20-positive expression and the monoclonal rearrangement of IgH gene may be mistaken for B-cell lymphoma; thus, the comprehensive evaluation of histomorphology, more extensive immunoprofiles and molecular studies is essential to reach the correct diagnosis.
|
29063643 |
2018 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
One case with monoclonal IgH gene rearrangements progressed into B-cell lymphoma.
|
28984697 |
2018 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Improved clonality detection in B-cell lymphoma using a semi-nested modification of the BIOMED-2 PCR assay for IGH rearrangement: A paraffin-embedded tissue study.
|
28868745 |
2017 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The biological significance of BAFF signalling in t(11;18)(q21;q21)-negative lymphoma cells was further studied in two types of lymphoma B cell: OCI-Ly3 [non-germinal centre B-cell origin DLBCL without t(11;18)(q21;q21) cell line] and MA-1 [t(14;18)(q32;q21)/IGH-MALT1-positive DLBCL cell line].
|
27873317 |
2017 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Large B-cell lymphomas with IGH@BCL2 and MYC rearrangement, known as double-hit lymphoma (DHL), are clinically aggressive neoplasms with a poor prognosis.
|
25103070 |
2015 |
B-Cell Lymphomas
|
0.200 |
Biomarker
|
group |
BEFREE |
Both cases of FL were positive for CD10 and B-cell lymphoma 2 (BCL-2), and immunoglobulin heavy locus (IgH)/B-cell lymphoma 2 rearrangement was observed by fluorescence in situ hybridization.
|
24767771 |
2014 |
B-Cell Lymphomas
|
0.200 |
Biomarker
|
group |
BEFREE |
We analyzed 46 B-cell lymphoma (B-NHL) specimens with known karyotypes for translocations of IGH-, BCL2-, BCL6- and MYC-genes.
|
24733537 |
2014 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This study was performed on samples from 70 patients with B-NHL, including two cases of follicular lymphoma (FL), 20 cases of diffuse large B-cell lymphoma (DLBCL), one case of mantle cell lymphoma (MCL), and 47 cases of B-cell neoplasm (non-classified), which had been previously assessed for complete IGH clonality, and failure to clarify gene rearrangements.
|
24862097 |
2014 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Studies of B cell lymphomas in the early 1980s led to the cloning of genes (c-MYC and IGH) at a chromosome translocation breakpoint.
|
22974238 |
2013 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Our data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of IGH translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma.
|
22420028 |
2012 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
We performed an immunogenetic analysis of 345 IGHV-IGHD-IGHJ rearrangements from 337 cases with primary splenic small B-cell lymphomas of marginal-zone origin.
|
22222599 |
2012 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
B-cell lymphomas with MYC/8q24 rearrangements and IGH@BCL2/t(14;18)(q32;q21): an aggressive disease with heterogeneous histology, germinal center B-cell immunophenotype and poor outcome.
|
22002575 |
2012 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
B-cell lymphomas with concurrent IGH-BCL2 and c-MYC rearrangements (so-called "double-hit lymphomas" [DHL]) are a relatively rare, recently described category in the 2008 World Health Organization classification of hematopoietic neoplasms.
|
21560252 |
2011 |
B-Cell Lymphomas
|
0.200 |
Biomarker
|
group |
BEFREE |
In conclusion, the detection IgH gene rearrangement by HRM in the LightCycler System showed potential for distinguishing monoclonality from polyclonality in B-cell non-Hodgkin lymphoma.
|
20482846 |
2010 |
B-Cell Lymphomas
|
0.200 |
Biomarker
|
group |
BEFREE |
The data suggest a common clonal origin of B-cell lymphoma and subsequent HS occurring in the same patient, indicating that 'transdifferentiation' occurs in other small B-cell lymphomas, in addition to the previously reported FL or B-cell lymphoma with IGH/BCL2.
|
20331331 |
2010 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
B-cell lymphomas with concurrent IGH-BCL2 and MYC rearrangements are aggressive neoplasms with clinical and pathologic features distinct from Burkitt lymphoma and diffuse large B-cell lymphoma.
|
20118770 |
2010 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
This was a retrospective evaluation of 98 consecutive BMTB specimens from 60 patients with a known B-cell neoplasm and a previous PCR marker of the disease (BCL2 and/or IGH).
|
19329714 |
2009 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
A biopsy of a nasal mass that had morphologic and immunostaining features consistent with a B-cell lymphoma was studied for clonality using PCR of the IgH gene.
|
17588658 |
2008 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?
|
17519619 |
2007 |
B-Cell Lymphomas
|
0.200 |
Biomarker
|
group |
BEFREE |
Analogous to B-cell lymphomas, in which the immunoglobulin (IgH) receptor loci are frequently targeted by chromosomal translocations, the T-cell receptor (TCR) gene loci are affected by translocations in a subset of precursor T-cell malignancies.
|
17582237 |
2007 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Molecular cytogenetics of IGH rearrangements in non-Hodgkin B-cell lymphoma.
|
18000389 |
2007 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
However, the molecular assessment of paraffin-embedded tissues revealed the monoclonal IgH gene rearrangement, which allowed the confident diagnosis of B cell lymphoma.
|
16465772 |
2006 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
For this reason, we report a splenic-based CD5(-), CD10(-), CD43(-), CD23(-), CD103(-), FMC7(+), CD25(+) small B-cell lymphoma associated with epithelioid histiocyte clusters and a t(14;19)(q32;q13) representing an IGH/BCL3 translocation based on classical cytogenetic studies, chromosomal painting, and fluorescence in situ hybridization studies.
|
16426923 |
2006 |
B-Cell Lymphomas
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Polymerase chain reaction (PCR)-based analysis, employed for detecting immunoglobulin heavy chain (IgH) gene rearrangements, has become a diagnostic tool widely used in the investigation of B-cell lymphomas, but the overall sensitivity of these methods does not exceed 80%, notably in germinal center (GC) and post-GC B-cell origin lymphomas.
|
16677778 |
2006 |