|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Finally, the disease-specific survival and the progression-free survival were significantly different between cases with mutated and unmutated IGHV genes, pointing out mutational status as a possible new biomarker in NMZL.
|
31802229 |
2019 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Survival analysis revealed that IgH gene rearrangement was significantly correlated with recurrence of orbital MALT lymphoma (p<0.001).
|
28678330 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The three translocations seen in MALT lymphoma, namely t(14;18)(q32;q21)/IGH-MALT1, t(1;14)(p22;q32)/BCL10-IGH, and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1 are capable of activating both canonical and non-canonical NF-κB pathways.
|
28288707 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The sensitivity of our scoring method, based on a comparison with the results of IgH gene monoclonal rearrangement detection, was 85.7% (18/21) for MALToma and 35.3% (6/17) for ALH.
|
28510589 |
2017 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Similarly, the three MALT lymphoma associated chromosome translocations, namely t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1,and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1, are also capable of activating both canonical and non-canonical NF-κB pathways.
|
27452667 |
2016 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In 50 cases of primary gastrointestinal MALT lymphoma (1) IGH arrangement was found in 59.5% of patients with primary gastrointestinal MALT lymphoma; IGH arrangement was found in 48.4% of patients with primary gastrointestinal MALT lymphoma at stage I-II and in 90.9% of patients at stage III-IV (χ(2) = 6.093, p < 0.05).
|
24272086 |
2014 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Although these findings suggest that t(14;18)/IGH-MALT1 is a rare molecular event in gastrointestinal MALT lymphomas and DLBCLs, further studies to elucidate the role of this genetic alteration in these diseases are indicated.
|
24236896 |
2014 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Overall, 12 (75%) patients with mucosal-associated lymphoid tissue lymphoma (n = 16) and 2 (40%) patients with diffuse large B-cell lymphoma (n = 5) were positive for monoclonal IgH gene rearrangements.
|
24039368 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MALT lymphomas were usually associated with a mutated IGHV gene, but with the absence of selection pressure.
|
22944768 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In conclusion, we identified several unbalanced aberrations and a t(11;14) involving IGH and DDX6 providing evidence for a contribution of DDX6 to lymphomagenesis by deregulation of BCL6 in NMZL.
|
22965301 |
2013 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
It currently remains unclear whether this one case, demonstrating IgH gene rearrangement in our series, could be a sign of the prelymphomatous stage (e.g. incipient MALT type lymphoma) or merely represents an exaggeration of normal B-cell clonal response.
|
19954895 |
2010 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We compared IGH VDJ sequences in 4 patients with 2 sequential sites of MALT lymphoma.
|
20551275 |
2010 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Mucosa-associated lymphoid tissue (MALT) lymphoma is characterized by t(11;18)(q21;q21)/API2-MALT1, t(1;14)(p22;q32)/BCL10-IGH and t(14;18)(q32;q21)/IGH-MALT1, which commonly activate the nuclear factor (NF)-kappaB pathway.
|
20520640 |
2010 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The molecular pathogenesis of MALT lymphoma arising in the ocular region rarely involves translocations in the MALT1- and IGH-gene loci.
|
19178392 |
2009 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The well-known translocations identified in MALT lymphomas include t(11;18)/API2-MALT1, t(1;14)/IGH-BCL10, and t(14;18)/IGH-MALT1.
|
18927281 |
2008 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
Association of t(14;18) translocation with HCV infection in gastrointestinal MALT lymphomas.
|
18538438 |
2008 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Analytical detection of IgH gene rearrangement in gastric lymphoid infiltrates by one-peak area analysis correctly distinguishes gastric MALT lymphomas from chronic gastritis, even in cases with diagnosis of abnormal lymphocytic infiltrates.
|
17591935 |
2007 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this case the detection of t(14;18)(q32;q21) involving IGH and MALT1 was useful for the differential diagnosis of LPL and MALT lymphoma.
|
17654058 |
2007 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We assessed the incidence and clinical significance of the MALT lymphoma-associated genetic abnormalities t(11;18)/API2-MALT1, t(1;14)/BCL10-IGH, t(14;18)/IGH-MALT1, t(3;14)/FOXP1-IGH, and extra copies of MALT1 and FOXP1 in gastric MALT lymphomas from Japan.
|
17525089 |
2007 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Five (27.8%) of the 18 patients showed different IgH gene rearrangements in the two components and three (60%) of these five patients had differential response of MALToma and DLBCL to HPET.
|
17167822 |
2007 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Other translocations involving IGH also are not involved in the pathogenesis of at least most cutaneous MALT lymphomas.
|
16630178 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The t(14;18)(q32;q21) involving the MALT1/MLT and IGH genes has been identified recently as a recurrent abnormality in mucosa-associated lymphoid tissue (MALT) lymphomas.
|
16364768 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
FusionGene
|
disease |
ORPHANET |
T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.
|
15703784 |
2005 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.
|
15682443 |
2005 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
T(3;14)(p14.1;q32) involving IGH and FOXP1 is a novel recurrent chromosomal aberration in MALT lymphoma.
|
15703784 |
2005 |