Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
BCP first rearrange their immunoglobulin (Ig) heavy chain (IGH) genes to form the pre-B-cell receptor (pre-BCR) complex together with surrogate light chains.
|
31849931 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia.
|
31243274 |
2019 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
At our institute, we incorporated the use of FGFR3/IGH dual-color dual-fusion DNA probes for confirmation of aneuploidy 4 and 14 in diagnostic B-ALL specimens.
|
27820126 |
2017 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Molecular studies revealed clonal immunoglobulin heavy-chain (IGH) gene rearrangement within the HS, suggesting linkage to his previous B-ALL.
|
26574666 |
2015 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B acute lymphoblastic leukemia with t(14;19)(q32;p13.1) involving IGH/EPOR: a clinically aggressive subset of disease.
|
24030742 |
2014 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our findings confirm that deregulated CEBPE plays a crucial role in the pathogenesis of CEBPE-IGH positive B-ALL.
|
22137487 |
2011 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The T-cell epitopes encoded by the IgHV gene in the B-ALL patients were predicted by SYFPEITHI and BIMAS programs and compared with those from 56 representative germline IgHV sequences in the genebank.
|
15889252 |
2005 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In a patient with precursor B-cell acute lymphoblastic leukemia (ALL) associated with eosinophilia that completely responded to induction chemotherapy, we assayed serial remission cerebrospinal fluid and bone marrow specimens for minimal residual disease using a quantitative polymerase chain reaction assay to assess for clone-specific immunoglobulin heavy-chain gene cluster (IGH) gene rearrangement.
|
12708906 |
2003 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We show that the B cell blockage at the pro-B to pre-B cell transition is due to a large homologous deletion in the IGH locus encompassing the IGHM gene leading to the inability to form a functional pre-BCR.
|
12200606 |
2002 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
B-precursor ALL cases (especially stage IV of Nadler's criteria) have V-D-J rearranged IgH genes on both alleles.
|
1405717 |
1992 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
SomaticCausalMutation
|
disease |
ORPHANET |
Kaplan-Meier plot analysis revealed no significant difference between adult precursor B-ALL patients with monoclonal or oligoclonal IgH gene rearrangements and their disease-free survival rates.
|
1554798 |
1992 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
No correlation was found between the immunophenotype of the ALL and the arrangement pattern of their IgH genes.
|
1554798 |
1992 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
DNA from 2 patients with pre-pre-B-ALL (CD10-) and 1 patient with common ALL contained rearranged Ig light chain (kappa in two, lambda in one case) in addition to rearranged IgH genes.
|
1850055 |
1991 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
As the detection limit of the Southern blot technique is 2-5%, it might well be that small subclones remained undetected, implying that the frequency of subclone formation at the IgH gene level in precursor B-ALL is probably higher than 40%.
|
1909409 |
1991 |
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We have used a more sensitive, polymerase chain reaction based immunoglobulin gene 'fingerprinting' approach in the analysis of B-cell clonality in eight patients with common ALL which were apparently monoclonal on the basis of Southern blot analysis of their IgH genes.
|
1961017 |
1991 |