IGH, immunoglobulin heavy locus, 3492

N. diseases: 238; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006413
Disease: Burkitt Lymphoma
Burkitt Lymphoma
0.400 GeneticVariation disease BEFREE Patients demonstrating a terminal deoxynucleotidyl transferase (TdT)-positive precursor B cell phenotype with IGH-MYC rearrangement have been reported to be molecularly distinct from BL and closer to B-ALL/LBL. 31705772 2020
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Since 2000, we have investigated 67 consecutive patients with stage I/II follicular lymphoma (FL) for the presence of BCL2/IGH rearrangements by polymerase chain reaction (PCR), real time quantitative PCR (RQ-PCR) and digital droplet PCR (ddPCR). 31385309 2020
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Although the majority of patients with follicular lymphoma (FL) harbor the t(14;18)(q32;q21) IGH/BCL2 gene rearrangement that leads to the overexpression of BCL2 protein, approximately 20% of FL cases lack t(14;18)(q32;q21). 31789408 2020
CUI: C0006413
Disease: Burkitt Lymphoma
Burkitt Lymphoma
0.400 GeneticVariation disease BEFREE Thus, the capacity of Tat to spontaneously penetrate B-cells could be sufficient to favor the occurrence of MYC-IGH oncogenic rearrangements during erroneous repair, a plausible cause for the increased incidence of Burkitt lymphoma in the HIV-infected population. 30701532 2019
CUI: C0006413
Disease: Burkitt Lymphoma
Burkitt Lymphoma
0.400 GeneticVariation disease BEFREE Cryptic insertion of <i>MYC</i> exons 2 and 3 into the IGH locus detected by whole genome sequencing in a case of MYC-negative Burkitt lymphoma. 31073073 2019
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The IGHV gene repertoire was remarkably biased in FL. 31209206 2019
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Cytogenetic analysis and targeted next-generation sequencing of both FL and HS tumors identified common genomic alterations such as IGH-BCL2 rearrangement, CREBBP and KMT2D, and aberrations of chromosomes 9q and 19q. 31807922 2019
Mucosa-Associated Lymphoid Tissue Lymphoma
0.400 Biomarker disease BEFREE Finally, the disease-specific survival and the progression-free survival were significantly different between cases with mutated and unmutated IGHV genes, pointing out mutational status as a possible new biomarker in NMZL. 31802229 2019
Precursor B-cell lymphoblastic leukemia
0.400 Biomarker disease BEFREE BCP first rearrange their immunoglobulin (Ig) heavy chain (IGH) genes to form the pre-B-cell receptor (pre-BCR) complex together with surrogate light chains. 31849931 2019
Precursor B-cell lymphoblastic leukemia
0.400 GeneticVariation disease BEFREE Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia. 31243274 2019
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Molecular cytogenetics showed IGH/BCL2 fusion in the follicular lymphoma and amplification of IGH gene or trisomy/tetrasomy 14 in the PTCL. 29217426 2018
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE A leukemic double-hit follicular lymphoma associated with a complex variant translocation, t(8;14;18)(q24;q32;q21), involving BCL2, MYC, and IGH. 29310838 2018
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Fluorescence in situ hybridization (FISH) identified an IGH-BCL2 rearrangement in both the FL and high-grade B-cell components while a MYC rearrangement was detected in the high-grade B-cell component alone. 29793519 2018
CUI: C0006413
Disease: Burkitt Lymphoma
Burkitt Lymphoma
0.400 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Oligonucleotide sets that probe breakpoints of <i>IGH-BCL2</i> (immunoglobulin heavy-apoptosis regulator) in follicular lymphoma (FL), <i>MYC-IGH</i> (MYC proto-oncogene, bHLH transcription factor-immunoglobulin heavy) in Burkitt lymphoma (BL) and <i>BCR-ABL1</i> (RhoGEF and GTPase activating protein-ABL proto-oncogene 1, non-receptor tyrosine kinase) in chronic myelogenous leukemia (CML) were designed. 28515100 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE Comparative analysis between RQ-PCR and digital droplet PCR of BCL2/IGH gene rearrangement in the peripheral blood and bone marrow of early stage follicular lymphoma. 28419517 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE The FL with signet-ring cell morphology (1/5) tends to lack IGH/BCL2 translocation, and an extended immunohistochemical study is recommended for correct diagnosis and classification of SRCL. 28038709 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE Follicular lymphoma (FL) is characterized genetically by a significant intraclonal diversity of rearranged immunoglobulin heavy chain (IGH) genes and a substantial cell migration activity (follicular trafficking). 28640838 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 Biomarker disease BEFREE The IGH gene rearrangement was mainly found in lymphoplasmacytoid lymphomas and follicular lymphomas. 29100365 2017
Mucosa-Associated Lymphoid Tissue Lymphoma
0.400 Biomarker disease BEFREE Survival analysis revealed that IgH gene rearrangement was significantly correlated with recurrence of orbital MALT lymphoma (p<0.001). 28678330 2017
Mucosa-Associated Lymphoid Tissue Lymphoma
0.400 GeneticVariation disease BEFREE The three translocations seen in MALT lymphoma, namely t(14;18)(q32;q21)/IGH-MALT1, t(1;14)(p22;q32)/BCL10-IGH, and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1 are capable of activating both canonical and non-canonical NF-κB pathways. 28288707 2017
Mucosa-Associated Lymphoid Tissue Lymphoma
0.400 GeneticVariation disease BEFREE The sensitivity of our scoring method, based on a comparison with the results of IgH gene monoclonal rearrangement detection, was 85.7% (18/21) for MALToma and 35.3% (6/17) for ALH. 28510589 2017
Precursor B-cell lymphoblastic leukemia
0.400 Biomarker disease BEFREE At our institute, we incorporated the use of FGFR3/IGH dual-color dual-fusion DNA probes for confirmation of aneuploidy 4 and 14 in diagnostic B-ALL specimens. 27820126 2017
CUI: C0024301
Disease: Lymphoma, Follicular
Lymphoma, Follicular
0.400 GeneticVariation disease BEFREE IGHV mutation analysis showed that all FL-B-LBL pairs harbored identical or near-identical somatic mutations. 27750045 2016
Mucosa-Associated Lymphoid Tissue Lymphoma
0.400 GeneticVariation disease BEFREE Similarly, the three MALT lymphoma associated chromosome translocations, namely t(1;14)(p22;q32)/BCL10-IGH, t(14;18)(q32;q21)/IGH-MALT1,and t(11;18)(q21;q21)/BIRC3 (API2)-MALT1, are also capable of activating both canonical and non-canonical NF-κB pathways. 27452667 2016