|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Because high anti-parasite IgG3 and low anti-parasite IgG4 levels were associated with malaria resistance, the chromosomal regions linked to IgG3 and IgG4 levels are of special interest.
|
25521226 |
2016 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multi-marker analysis revealed a significant contribution of IgG3 responses to malaria protection and IgG2 responses to malaria risk.
|
30930896 |
2019 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The IL4-590T allele was significantly associated with anti-P. falciparum IgG3 antibody levels in patients with complicated (P = 0.031), but not with uncomplicated malaria (P = 0.622).
|
20003246 |
2009 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
IgG3, known to have the shortest half-life of the IgG subclasses, might be the most temporally relevant indicator of ongoing malaria exposure when examining antibody responses to AMA1.
|
30658710 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Serum IgG3 to the Plasmodium falciparum merozoite surface protein 2 is strongly associated with a reduced prospective risk of malaria.
|
14507328 |
2003 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings support previous studies that found OP of merozoites to be associated with protection against malaria and further shows IgG3 and GLURP antibodies are key in the OP mechanism, thus giving further impetus for the development of malaria vaccines targeting GLURP.
|
28329101 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study examines the hypotheses that the IgG3-H435 variant promotes increased transplacental transfer of malaria-specific antibodies and a prolonged IgG3 half-life in infants and that its presence correlates with protection against clinical malaria during infancy.
|
28991911 |
2017 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, our main objective was to study the changes in MSP2-specific total IgG, IgG1 and IgG3 responses during a malaria transmission season in order to assess the impact of sickle-cell, α(+)-thalassemia and G6PD variants on antibody kinetics.
|
21549219 |
2011 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
(i) All blocks were targeted by naturally acquired cytophilic antibodies of the subclasses IgG1 and IgG3, but the balance between IgG1 and IgG3 depended on the subjects' cumulative exposure to malaria.
|
10531247 |
1999 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
However infants from CAIG (n = 53) had significantly higher AMA1-, MSP2-FC27-, MSP3-specific IgG1 and AMA1-, MSP1-, MSP2-FC27-, MSP3 and GLURP-R2-specific IgG3 than those from NCIG (n = 183).
|
31185998 |
2019 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
The levels of IgG and IgG3 to MSP2/3D7 were negatively associated with the risk of occurrence of a malaria attack during the following transmission season.
|
16679042 |
2006 |
|
Malaria
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We performed a family-based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the HLA-G 3' untranslated region associated with antibody response to specific Plasmodium falciparum blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2.
|
23745572 |
2013 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Of the 30 immune responses measured, only one, antibodies of the IgG3 isotype directed to merozoite surface protein 3 (MSP3), was strongly associated with clinical protection against malaria in all age groups, i.e., independently of age.
|
18001147 |
2007 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Previously, we reported that the levels of IgG2 and IgG3 to Pf332-C231 malaria antigen are negatively correlated with number of malaria episodes.
|
21729768 |
2011 |
|
Malaria
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The highest levels of IgG, IgG1, IgG2 and IgG3 antibodies were observed in individuals with asymptomatic and uncomplicated malaria, while highest levels of IgG4, IgE and IgM antibodies were predominant among individuals with complicated malaria.
|
18816374 |
2008 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
(3) The overall pattern of human IgG antibody responses to MSP-2 in Karitiana Indians, a population continuously exposed to hypoendemic malaria in the Brazilian Amazon Region, differs from that described in hyperendemic areas in Africa and Papua New Guinea in two important features: there was no clear age-dependent increase in the prevalence and mean concentration of specific IgG antibodies, and there was no skewing towards the IgG3 subclass in antibody responses.
|
11596920 |
2002 |
|
Malaria
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, a combination of IgG3 antibody responses against Pf12, MSP3.7, MSP3.3, and MSP2FC27 was strongly associated with protection against febrile malaria (HR = 0.15; 95% CI, .06-.37; P = .0001).
|
29733355 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate herein that the accelerated development of lupus-like autoimmune disease in MRL-lpr/lpr and MRL.Yaa mice, as compared with MRL-lpr/lpr.ll and MRL-+/+ mice, respectively, was correlated with an enhanced expression of IFN-gamma vs IL-4 and IL-10 mRNA in CD4+ T cells, which paralleled with an increase of spontaneous and foreign T cell-dependent antigen-induced productions of IgG2a and IgG3 vs IgG1 antibodies.
|
8601623 |
1996 |
|
Lupus Erythematosus, Systemic
|
0.060 |
Biomarker
|
disease |
BEFREE |
The role of the Yaa gene for the acceleration of SLE is apparently two-fold; it enhances overall autoimmune responses against autoantigens to which mice respond relatively weakly, and promotes Th 1 responses against autoantigens to which mice respond relatively well, leading to the production of more pathogenic autoantibodies, i.e., FcgammaR-fixing IgG2a and cryoglobulin IgG3 autoantibodies.
|
11016427 |
2000 |
|
Lupus Erythematosus, Systemic
|
0.060 |
Biomarker
|
disease |
BEFREE |
In addition, the roles of IgG4-IgG1 (IgG4-IgG2 or IgG4-IgG3)-complexes and bispecific IgG4 in SLE and RA are also reviewed.
|
28472610 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.060 |
Biomarker
|
disease |
BEFREE |
Patients with low IgG3 or IgG4 presented higher frequency of lupus nephropathy.
|
27274095 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.060 |
Biomarker
|
disease |
BEFREE |
To clarify the role played by Fkn in the development of glomerular lesions in lupus nephritis, we examined Fkn expression and CD16(+) Mo accumulation induced in experimental C.B-17/Inc-scid/scid (SCID) lupus model mice by injection of IgG(3)-producing hybridoma clones obtained from MRL/lpr mice.
|
20410215 |
2010 |
|
Lupus Erythematosus, Systemic
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
The Fc gamma RIIIA-V/F158 polymorphism affects immunoglobulins (Ig)G1- and IgG3-binding capacity and may modulate the expression of renal disease in patients with systemic lupus erythematosus (SLE).
|
12631364 |
2003 |
|
Clinical malaria
|
0.060 |
Biomarker
|
disease |
BEFREE |
This study examines the hypotheses that the IgG3-H435 variant promotes increased transplacental transfer of malaria-specific antibodies and a prolonged IgG3 half-life in infants and that its presence correlates with protection against clinical malaria during infancy.
|
28991911 |
2017 |
|
Clinical malaria
|
0.060 |
Biomarker
|
disease |
BEFREE |
In a large population study in The Gambia, serum positivity for IgG or IgG1 and IgG3 subclass antibodies to each of the EBA-175 recombinant antigens was not significantly associated with subsequent protection from clinical malaria.
|
10992454 |
2000 |