Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease.
|
1671712 |
1991 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease.
|
1678058 |
1991 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Vitamin E protects nerve cells from amyloid beta protein toxicity.
|
1497677 |
1992 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found a novel point mutation, substitution of cytosine for guanine, at nucleotide 2119 (amyloid precursor protein 770 messenger RNA transcript) in a patient with late-onset Alzheimer's disease.
|
8154870 |
1994 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
BEFREE |
We suggest that this long transcript may alter the normal pathway for processing of amyloid precursor protein, the protein which appears to be central in the pathogenesis of AD.
|
8910899 |
1996 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the distribution of the PS-1 intronic polymorphism in patients with sporadic AD and in seven familial AD (FAD) families carrying pathogenetic mutations in the amyloid precursor protein (APP) and Presenilin (PS-1 and PS-2) genes.
|
9111746 |
1997 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic variability at the amyloid-beta precursor protein locus may contribute to the risk of late-onset Alzheimer's disease.
|
10430506 |
1999 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
BEFREE |
We also examined, by Western blotting, the level of beta-amyloid precursor protein (APP) which is involved in AD.
|
10672260 |
1999 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The amyloid precursor protein locus and very-late-onset Alzheimer disease.
|
11500807 |
2001 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
|
12192006 |
2002 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A second locus for very-late-onset Alzheimer disease: a genome scan reveals linkage to 20p and epistasis between 20p and the amyloid precursor protein region.
|
12016588 |
2002 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this article, we studied the frequency of mutations in the presenilin (PSEN) 1, PSEN2 and amyloid precursor protein genes in a group of patients with late-onset Alzheimer's disease (AD).
|
11803125 |
2002 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
|
12572668 |
2003 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
|
12746438 |
2003 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
|
12852432 |
2003 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
APP(670, 671) mutation carriers demonstrate regional brain neurofibrillary changes characteristic of late-onset Alzheimer's disease with evidence for more Abeta deposition for epsilon4/4 than epsilon2/3.
|
12169205 |
2003 |
Alzheimer Disease, Late Onset
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Risk for late onset Alzheimer disease (LOAD) and plasma amyloid beta levels (Abeta42; encoded by APP), an intermediate phenotype for LOAD, show linkage to chromosome 10q.
|
15024728 |
2004 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
|
15590663 |
2005 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease.
|
15714520 |
2005 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
|
16204253 |
2005 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
|
15591071 |
2005 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
|
15993441 |
2005 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
CTD_human |
Beta-amyloid mediated nitration of manganese superoxide dismutase: implication for oxidative stress in a APPNLH/NLH X PS-1P264L/P264L double knock-in mouse model of Alzheimer's disease.
|
16651627 |
2006 |
Alzheimer Disease, Late Onset
|
0.400 |
Biomarker
|
disease |
BEFREE |
LRRTM3 promotes processing of amyloid-precursor protein by BACE1 and is a positional candidate gene for late-onset Alzheimer's disease.
|
17098871 |
2006 |
Alzheimer Disease, Late Onset
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Characterization of two APP gene promoter polymorphisms that appear to influence risk of late-onset Alzheimer's disease.
|
16243604 |
2006 |