APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Forgetful ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE Tooth loss induces memory impairment and neuronal cell loss in APP transgenic mice. 23773908 2013
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE In mice, inhibition or siRNA-mediated silencing of PDK1 extends survival and reduces motor impairment following PrP(Sc) infection and in APP-transgenic mice reduces Alzheimer's disease-like pathology and memory impairment. 23955714 2013
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE The studied dendrimers did not reverse memory impairment in APP/PS1 mice following chronic administration; moreover, cationic G4mOS caused cognitive decline in nontransgenic mice. 24004423 2013
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE These results suggest that the sensorimotor gating is impaired with the progressing of AD phenotype, and its deficit may be correlated to cerebral Aβ neuropathology and memory impairment in the APP/PS1 transgenic mouse model of AD. 22595040 2012
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE Here, we demonstrated that HFD markedly deteriorated memory impairment and increased β-amyloid (Aβ) oligomers as well as Aβ deposition in amyloid precursor protein (APP) transgenic mice, which was reversed by exposure to an enriched environment for 10 weeks, despite the continuation of HFD. 22197104 2012
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE In Tg2576 mice, knockdown by short hairpin RNA or knockout of the S100a9 gene significantly reduced the neuropathology, greatly improved the learning and memory impairment and reduced the amount of Aβ and APP-CTs by increasing neprilysin and decreasing BACE activity. 22301734 2012
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE Spatial learning and memory impairment and increased locomotion in a transgenic amyloid precursor protein mouse model of Alzheimer's disease. 21443906 2011
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE Here, we show that Sod1 deficiency in an amyloid precursor protein-overexpressing mouse model (AD mouse, Tg2576) accelerated Aβ oligomerization and memory impairment as compared with control AD mouse and that these phenomena were basically mediated by oxidative damage. 22072713 2011
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 GeneticVariation phenotype BEFREE Tg19959 mice carry human APP with two mutations and develop amyloid plaques and memory impairment starting at 3-4 months of age. 19914323 2010
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE Moreover, the amelioration ability of this compound against the in vivo memory impairment was further evaluated by APP-PS1 double transgenic mice model. 20412384 2010
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE Here, in mice overexpressing wild-type human APP (hAPP(wt)) we found an early memory impairment, particularly in the water maze and to a lesser extent in the object recognition task, but beta-amyloid peptide (Abeta(42)) was barely detectable in the hippocampus. 19101630 2009
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 AlteredExpression phenotype BEFREE Accumulations increased with age, and this was paralleled by decreased brain sizes on volumetric MRI, compared to age-matched and similar transgene-expressing APP wild-type mice, although, with these levels of transgenic expression we did not detect neuronal loss or significant memory impairment. 17112635 2008
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype BEFREE The results suggest that plaque formation is not a necessary condition for the neuronal beta-APP(751) transgene-induced memory impairment, which may be caused by beta-APP overexpression, isoform misexpression, or elevated soluble Abeta. 11724968 2001
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 GeneticVariation phenotype BEFREE Transgenic mice carrying AD-causing mutations in APP develop spontaneous age-related beta-amyloid (A beta) deposition and memory impairment. 9052714 1997
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 GeneticVariation phenotype BEFREE In two unrelated UK families with APP 717 val-ile mutations there was early prominent memory impairment with dyscalculia proceeding to generalized cognitive impairment with a lack of insight. 8239283 1993
CUI: C0542476
Disease: Forgetful
Forgetful 		0.200 Biomarker phenotype HPO