|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
The objective of our study was to evaluate for the first time the effectiveness of a self-guided mobile-based intervention primarily targeting agoraphobic symptoms, with respect to a generic mobile app targeting anxiety.
|
29175809 |
2017 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Here we identified that overexpression of EphB2 with lentiviral vectors in dorsal hippocampus improved impaired memory deficits and anxiety or depression-like behaviors in APPswe/PS1-dE9 (APP/PS1) transgenic mice.
|
28358367 |
2017 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Aged APP/PS1 mice had reference memory deficits as well as anxiety, hyperactivity, and social interaction impairment.
|
27439903 |
2016 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
First, our study verifies the ameliorative effects of donepezil on behavioral deficits in both working memory and anxiety in APP/PS1 double transgenic mice, at a time point that AChE is not inhibited.
|
25744714 |
2015 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Dutch APP(E693Q) transgenic mice accumulate oligomeric Aβ as they age, as well as Aβ oligomer-dose-dependent anxiety and impaired novel object recognition (NOR).
|
25349165 |
2015 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
In contrast to motor activity, the age of APP onset had no effect on thigmotaxis in the open field as a rough measure of anxiety, suggesting that the interaction between APP overexpression and brain development is not unilateral.
|
22709352 |
2012 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Altered temporal patterns of anxiety in aged and amyloid precursor protein (APP) transgenic mice.
|
21709248 |
2011 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
CTD_human |
Fear responses might reflect an influence of anxiety, because the anxiolytic compounds valproate, diazepam, and buspirone reduced efficiently unconditioned and conditioned fear responses in APP transgenic mice.
|
19664757 |
2010 |
|
Anxiety Disorders
|
0.400 |
Biomarker
|
group |
BEFREE |
Fear responses might reflect an influence of anxiety, because the anxiolytic compounds valproate, diazepam, and buspirone reduced efficiently unconditioned and conditioned fear responses in APP transgenic mice.
|
19664757 |
2010 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Behavioral experiments showed that APP(751SL) mice displayed alterations in some general functions (muscular strength, motor activity) whereas other functions are preserved (anxiety, exploration).
|
19428628 |
2009 |
|
Anxiety Disorders
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The Tg-APP (Sw, V717F)/B6 mice at 11-14 months displayed decreased motor coordination, learning and memory deficits, and severely increased anxiety.
|
15114629 |
2004 |