Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the proteomic profiles of amyloid plaques (APs) from Alzheimer's disease (AD) and age-matched non-AD brains and APP/PS1 transgenic model mice.
|
30502339 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amyloid-β (Aβ) is derived from the proteolytic processing of amyloid precursor protein (APP), and the deposition of extracellular Aβ to form amyloid plaques is a pathologic hallmark of Alzheimer's disease (AD).
|
31373844 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Stress increases cognitive dysfunction, generates amyloid precursor protein (APP), hyperphosphorylated tau, neurofibrillary tangles (NFTs), and amyloid plaques (APs) in the brain.
|
30837843 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Amyloid-β (Aβ) peptides, major components of amyloid plaques and crucial pathogenic molecules in terms of the amyloid hypothesis, are derived from successive proteolytic processing of amyloid-β precursor protein (APP).
|
31606373 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results demonstrated that social housing improved the behavioral performance of APP/PS1 mice in Morris Water Maze testing, without significantly altering the rates of amyloid plaque deposition or amyloidogenic APP processes.
|
31034995 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
In human amyloid precursor protein transgenic Tg2576 mice with amyloid plaque pathology, similar neuronal HTT expression patterns and a distinct association of HTT with Abeta plaques were revealed by immunohistochemical double labelling.
|
31109380 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
This disorder is characterized by the accumulation of beta amyloid plaques (Aβ) resulting from impaired amyloid precursor protein (APP) metabolism, together with the formation of neurofibrillary tangles and tau protein hyperphosphorylation.
|
31816853 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
The major components of β-amyloid plaques are Aβ<sub>1-42</sub> and Aβ<sub>1-40</sub> peptides derived from the APP.
|
30526133 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Imaging and Spectral Characteristics of Amyloid Plaque Autofluorescence in Brain Slices from the APP/PS1 Mouse Model of Alzheimer's Disease.
|
31127445 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Age Moderates the Effects of Traumatic Brain Injury on Beta-Amyloid Plaque Load in APP/PS1 Mice.
|
30623730 |
2019 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
CTD_human |
Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat.
|
29729307 |
2018 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
δ-Secretase, an age-dependent asparagine protease, cleaves both amyloid precursor protein (APP) and Tau and is required for amyloid plaque and neurofibrillary tangle pathologies in Alzheimer's disease (AD).
|
30382187 |
2018 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Cleavage of APP leads to formation of β-amyloid plaque, which is a hallmark of Alzheimer's disease (AD).
|
28628788 |
2017 |
Plaque, Amyloid
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease.
|
28637503 |
2017 |
Plaque, Amyloid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Collectively, our results suggest that different pathological mechanisms, namely an intracellular accumulation of APP or extracellular amyloid plaques, may lead to spine abnormalities in young adult APP23 and deltaE9 mice, respectively.
|
25862638 |
2015 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis.
|
20850464 |
2011 |
Plaque, Amyloid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The APP(E693Q) mice did not develop amyloid plaques at any age studied, up to 30 months.
|
20641005 |
2010 |
Plaque, Amyloid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Tg19959 mice carry human APP with two mutations and develop amyloid plaques and memory impairment starting at 3-4 months of age.
|
19914323 |
2010 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice.
|
20813165 |
2010 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
CTD_human |
Up-regulated expression of amyloid precursor protein (APP) occurs early in the cascade of events that leads to amyloid plaque formation in the human brain.
|
19818510 |
2009 |
Plaque, Amyloid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the simultaneous presence of human mutated Tau(VLW) and plaque-amyloid (and/or APP(SW)) potentiates and anticipates tau phosphorylation at the 12E8 epitope, intensifying pyramidal neuron immunostaining and tau filament formation in this double-transgenic model.
|
18679696 |
2008 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
Furthermore, Alzheimer's amyloid precursor protein, which accumulates within the axonal swellings under pathological conditions, co-accumulated with the PrP-amyloid plaques.
|
18751990 |
2008 |
Plaque, Amyloid
|
0.400 |
Biomarker
|
disease |
BEFREE |
A novel magnetic resonance (MR) imaging contrast agent based on a derivative of human amyloid beta (Abeta) peptide, Gd[N-4ab/Q-4ab]Abeta 30, was previously shown to cross the blood-brain barrier (BBB) and bind to amyloid plaques in Alzheimer's disease (AD) transgenic mouse (APP/PS1) brain.
|
17505020 |
2007 |
Plaque, Amyloid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In addition, for animals older than 12 months, we confirmed our previous report that only the two genotypes that form amyloid plaques (APP and PS/APP) have significantly reduced T(2) values compared with NTg controls.
|
17451178 |
2007 |
Plaque, Amyloid
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques.
|
16169151 |
2005 |