|
Brain Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen activated protein kinase (MAPK) and cyclic-AMP pathways, less is known about its role in multiple brain disorders where it contributes to the dysregulated neuroplasticity seen in epilepsy and traumatic brain injury (TBI).
|
31455240 |
2019 |
|
Endocarditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we studied the phenotypic alterations induced by the increased intracellular c-di-AMP levels in <i>Streptococcus gallolyticus</i>, an opportunistic pathogen responsible for septicemia and endocarditis in the elderly.We report that an <i>S. gallolyticus</i> c-di-AMP phosphodiesterase <i>gdpP</i> knockout mutant, which displays a 1.5-fold higher intracellular c-di-AMP levels than the parental strain UCN34, is more sensitive to osmotic stress and is morphologically smaller than the parental strain.
|
30617242 |
2019 |
|
Epilepsy
|
0.010 |
Biomarker
|
disease |
BEFREE |
While much is known about BDNF signaling in the healthy nervous system where it controls the mitogen activated protein kinase (MAPK) and cyclic-AMP pathways, less is known about its role in multiple brain disorders where it contributes to the dysregulated neuroplasticity seen in epilepsy and traumatic brain injury (TBI).
|
31455240 |
2019 |
|
Hyperalgesia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice.
|
31324647 |
2019 |
|
Hypercholesterolemia
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, we found that policosanol supplementation stimulated an increase in fecal cholesterol and bile acid contents and deactivated 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase by AMP-activated protein kinase (AMPK) phosphorylation during high-fat and high-cholesterol-containing diet-induced development of hypercholesterolemia.
|
31613687 |
2019 |
|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated whether the AMP-kinase activator AICAR ameliorates cisplatin-induced AKI through the JAK/STAT/SOCS pathway.
|
30616891 |
2019 |
|
Liver Cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The current work was engrossed to weigh the potential role of Cichorium intybus linn against thioacetamide (TAA)-induced liver cirrhosis and their probable underlying biochemical and molecular mechanisms. farnesoid-X-receptor (FXR) expression, proliferating cell nuclear antigen (PCNA) immunoreactivity, and activated AMP protein kinase (pAMPK), sirtuin-1 (SIRT1), and interleukin-6 (IL6) levels were estimated in hepatic tissue by real-time PCR, immunohistochemistry, and immunoassay, respectively.
|
31368578 |
2019 |
|
Multiple Endocrine Neoplasia Type 1
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Here, TENGEN proposes adjustments to the ACMG-AMP framework for the interpretation of MEN1 missense variants.
|
30869828 |
2019 |
|
Nephroblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Wilms tumor 1 (WT1), Zonula occludens-1 (ZO-1), AMP activated protein kinase (AMPK), and NADPH oxidase-4 (NOX-4) expression were evaluated by immunohistochemistry and Western blot.
|
30820023 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Recent evidence has revealed that AMP‑activated protein kinase (AMPK) in the central nervous system (CNS) regulates the neuropeptide calcitonin gene‑related peptide (CGRP), a principal neurotransmitter of the class C nerve fiber, which serves an important role in initiating and maintaining neuropathic pain.
|
31173269 |
2019 |
|
Pain, Postoperative
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Antihyperalgesia effect of AMP-activated protein kinase (AMPK) activators in a mouse model of postoperative pain.
|
31229963 |
2019 |
|
Pulmonary Fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Combined Activation of Guanylate Cyclase and Cyclic AMP in Lung Fibroblasts as a Novel Therapeutic Concept for Lung Fibrosis.
|
30984775 |
2019 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we aim to examine the relationship between genetic polymorphism and transcriptional expression of cyclic AMP response element binding protein (<i>CREBBP</i>) and the risk of diffuse large B-cell lymphoma (DLBCL).
|
31366566 |
2019 |
|
Hypocholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ang II-induced inositol phosphate production through AT<sub>1</sub> receptor was suppressed by cholesterol depletion from cell membranes using rosuvastatin or methyl-β-cyclodextrin (MβCD), whereas isoproterenol-induced cyclic AMP production through β<sub>1</sub>-Ad receptor did not change after cholesterol depletion.
|
31079923 |
2019 |
|
Malignant neoplasm of mouth
|
0.010 |
Biomarker
|
group |
BEFREE |
Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways during Black Raspberry-Mediated Oral Cancer Chemoprevention.
|
31336728 |
2019 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Metformin Induces Apoptosis and Inhibits Proliferation through the AMP-Activated Protein Kinase and Insulin-like Growth Factor 1 Receptor Pathways in the Bile Duct Cancer Cells.
|
31205529 |
2019 |
|
Cervical Intraepithelial Neoplasia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Seven metabolites (AMP, aspartate, glutamate, hypoxanthine, lactate, proline, and pyroglutamate) were discriminated between CINs and cervical cancer versus normal (area under the curve (AUC) value > 0.8).
|
30974861 |
2019 |
|
Neuroendocrine Tumors
|
0.010 |
Biomarker
|
group |
BEFREE |
Here, we compared the interpretation of the 122 MEN1 missense variants, identified in the French population over the past 15 years by the TENGEN network (French oncogenetics network of neuroendocrine tumors) versus by using the ACMG-AMP guidelines, and analyzed the causes of discordance.
|
30869828 |
2019 |
|
Lip and Oral Cavity Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Metabolic Regulation of Glycolysis and AMP Activated Protein Kinase Pathways during Black Raspberry-Mediated Oral Cancer Chemoprevention.
|
31336728 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants in the liver kinase B1-AMP-activated protein kinase pathway genes and pancreatic cancer risk.
|
30997723 |
2019 |
|
Gastroparesis with diabetes mellitus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To observe changes in AMP-activated protein kinase (AMPK) activity and phosphorylation changes in AMPK signaling pathway in gastric smooth muscle cells of rats with diabetic gastroparesis (DGP), investigate the effect of AMPK on apoptosis and explore the underlying mechanism.
|
31769476 |
2019 |
|
Disorder of purine metabolism
|
0.010 |
Biomarker
|
group |
BEFREE |
Adenine phosphoribosyltransferase (APRT) deficiency is a hereditary purine metabolism disorder that causes kidney stones and chronic kidney disease (CKD).
|
30443743 |
2019 |
|
Impaired glucose tolerance
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
5'-AMP administration resulted in an increase in dose-dependent purine metabolites and different levels of glucose intolerance.
|
31447776 |
2019 |
|
Childhood Hepatocellular Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib.
|
30959553 |
2019 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Targeting AMP-activated kinase impacts hepatocellular cancer stem cells induced by long-term treatment with sorafenib.
|
30959553 |
2019 |