Pheochromocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
(3) p53, Bcl-2, mdm-2, cyclin D1, p21, and p27 appear to have no role in predicting the behavior of pheochromocytomas.
|
18549892 |
2008 |
Adrenal Gland Pheochromocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
(3) p53, Bcl-2, mdm-2, cyclin D1, p21, and p27 appear to have no role in predicting the behavior of pheochromocytomas.
|
18549892 |
2008 |
Squamous cell carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
1,25(OH)2 vitamin D3 induces elevated expression of the cell cycle-regulating genes P21 and P27 in squamous carcinoma cell lines of the head and neck.
|
11270487 |
2001 |
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry.
|
15627896 |
2005 |
Malignant neoplasm of breast
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry.
|
15627896 |
2005 |
Breast Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry.
|
15627896 |
2005 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
279 patients with infiltrating metastasis-free breast cancer were included in this study. p27 expression was determined in tumor tissue specimens from 261 patients by immunohistochemistry.
|
15627896 |
2005 |
Pancreatitis, Chronic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Chronic pancreatitis was present in all of the cases. p27 immunoreactivity always exceeded the immunoreactivity of cyclin E. K-ras oncogene mutations were detected in two cases.
|
10349991 |
1999 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumor site (alveolus) was also associated with shorter disease-free (though not overall) survival, but the association with p27 was independent of stage and site in multivariate analysis.
|
10443844 |
1999 |
High Grade Lymphoma (neoplasm)
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
High grade lymphomas showed markedly decreased p21 expression (3.9 in Hg-NHL vs. 12 in Lg-NHL and 29 in CLL; values expressed as mRNA transcripts x 10(3), p < 0.009). mRNA and protein expression of p27 was considerably higher in CLL than in the lymphomas.
|
11042528 |
2000 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumors with high Skp2 (>20% positive cells) expression invariably showed reduced or absent p27 and tumors with high p27 (>20% positive cells) expression rarely showed Skp2 positivity.
|
11309491 |
2001 |
Adenocarcinoma
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Adenocarcinomas (AdCs) exhibited higher p27 levels compared to squamous cell carcinomas (SqCCs) (p < 0.01).
|
11474135 |
2001 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tumor biopsy specimens were examined for p21 and p27 expression using an immunohistological method.
|
16012042 |
2005 |
Thyroid Neoplasm
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Thyroid cancer cell lines and tissues with high levels of Skp2 protein presented high p27 degradation activity and there was an inverse correlation between Skp2 and p27 expression in thyroid cancer tissues (n=68; P<0.05).
|
17639054 |
2007 |
Malignant neoplasm of thyroid
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Thyroid cancer cell lines and tissues with high levels of Skp2 protein presented high p27 degradation activity and there was an inverse correlation between Skp2 and p27 expression in thyroid cancer tissues (n=68; P<0.05).
|
17639054 |
2007 |
Thyroid carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Thyroid cancer cell lines and tissues with high levels of Skp2 protein presented high p27 degradation activity and there was an inverse correlation between Skp2 and p27 expression in thyroid cancer tissues (n=68; P<0.05).
|
17639054 |
2007 |
Hepatitis D Infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hepatitis delta virus (HDV)-RNA shows a microheterogeneity at nucleotide 1015 resulting in the production of two co-terminal forms of the HDV-associated antigen (HDAg), referred to as p24 and p27.
|
1822506 |
1991 |
Helicobacter pylori (H. pylori) infection in conditions classified elsewhere and of unspecified site
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter.
|
22867947 |
2012 |
Multiple Endocrine Neoplasia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Multiple endocrine neoplasia syndromes associated with mutation of p27.
|
23800691 |
2013 |
Pituitary Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Pituitary tumors are one of the major clinical components of syndromes associated with the p27 pathogenic mutations MENX and MEN4.
|
24532476 |
2014 |
Caffeine related disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Caffeine also reduces infarct size after myocardial infarction in prediabetic mice and increases mitochondrial p27.
|
29927970 |
2018 |
Idiopathic pulmonary arterial hypertension
|
0.020 |
Biomarker
|
disease |
BEFREE |
TRAM-34 may protect against hypoxia-induced PAH.
|
28679649 |
2017 |
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRAM -34 significantly attenuated cardiac fibrosis and the inflammatory reaction and reduced the number of fibroblast precursor cells and myofibroblasts.
|
30563389 |
2019 |
Prostatic Intraepithelial Neoplasias
|
0.010 |
Biomarker
|
disease |
BEFREE |
A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression.
|
18691549 |
2008 |
Renal Cell Carcinoma
|
0.060 |
Biomarker
|
disease |
BEFREE |
A decrease in p27 expression has been reported in many kinds of tumors, but little is known regarding p27 in patients with renal cell carcinoma (RCC).
|
11920465 |
2002 |