|
Adenocarcinoma, Endometrioid
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
High p27 expression was linked to higher grades of endometrioid adenocarcinoma, cell proliferation and some clinical prognostic factors.
|
12085261 |
2002 |
|
Adenoid Cystic Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Skp2 expression is associated with down-regulation of p27 protein and cell proliferation in salivary adenoid cystic carcinoma.
|
17431674 |
2007 |
|
Adenoma
|
0.050 |
Biomarker
|
group |
BEFREE |
Overexpression of cyclin E/Cdk2 and loss of p27 appears to be associated with a poor prognosis and might play a role in the treatment of GHPAs in the future.
|
30196178 |
2019 |
|
Adenoma
|
0.050 |
Biomarker
|
group |
BEFREE |
Positive p27 staining rates were significantly higher in serous adenomas (p=0.006) and in serous LMP tumors (p=0.013) than that in serous carcinomas (Fisher's exact test).
|
11295040 |
2001 |
|
Adenoma
|
0.050 |
Biomarker
|
group |
BEFREE |
We aimed to investigate the expressions of p27 kinase inhibitory protein 1 (p27<sup>Kip1</sup>) and calcium sensing receptor (CaSR) in adenomas and normal parathyroid tissue and to evaluate the relationship of these molecules with clinical and biochemical parameters in primary hyperparathyroidism (PHPT).
|
29589297 |
2018 |
|
Adenoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemical expression of phospho-Akt was found to be higher in the tumours than normal pituitaries, while the protein expression of nuclear p27 and PTEN was lower in the adenomas.
|
15947113 |
2005 |
|
Adenoma
|
0.050 |
AlteredExpression
|
group |
BEFREE |
High Ki-67 proliferative index was seen in 2% of adenomas and 25% of carcinomas, whereas p27 expression was present in 80% of adenomas and 18% of carcinomas.
|
12605367 |
2003 |
|
Adrenal Cortical Adenoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This editorial summarizes some of these advances: the identification of the AIP, and the PDE11A and PDE8B genes by genome-wide association (GWA) studies as predisposing genes for pituitary and adrenal tumours, respectively, the discovery of p27 mutations in a new form of MEN similar to MEN type 1 (MEN 1) that is now known as MEN 4, the molecular investigations of Carney triad (CT), a disorder that associates paragangliomas (PGLs), gastrointestinal stromal tumour (GISTs), and pulmonary chondromas (PCH) with pheochromocytomas and adrenocortical adenomas and other lesions, and the molecular elucidation of the association of GISTs with paragangliomas (Carney-Stratakis syndrome) that is now known to be because of SDHB, SDHC, and SDHD mutations.
|
19522821 |
2009 |
|
Adrenal Gland Pheochromocytoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
(3) p53, Bcl-2, mdm-2, cyclin D1, p21, and p27 appear to have no role in predicting the behavior of pheochromocytomas.
|
18549892 |
2008 |
|
Adrenal Gland Pheochromocytoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
This editorial summarizes some of these advances: the identification of the AIP, and the PDE11A and PDE8B genes by genome-wide association (GWA) studies as predisposing genes for pituitary and adrenal tumours, respectively, the discovery of p27 mutations in a new form of MEN similar to MEN type 1 (MEN 1) that is now known as MEN 4, the molecular investigations of Carney triad (CT), a disorder that associates paragangliomas (PGLs), gastrointestinal stromal tumour (GISTs), and pulmonary chondromas (PCH) with pheochromocytomas and adrenocortical adenomas and other lesions, and the molecular elucidation of the association of GISTs with paragangliomas (Carney-Stratakis syndrome) that is now known to be because of SDHB, SDHC, and SDHD mutations.
|
19522821 |
2009 |
|
Adult Acute Lymphocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
At diagnosis, p21 methylation was not detected in any case of AML or ALL. p27 methylation occurred in 2 (4%) AML patients and in 1 (4%) ALL patient. p57 methylation occurred in 1 (2%) AML patient and in 1 (4%) ALL patient.
|
16315255 |
2005 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Starting from the observation that the growth-inhibitory and proapoptotic effects of miR-340 correlate with the accumulation of p27 in lung adenocarcinoma and glioblastoma cells, we have analyzed the functional relationship between miR-340 and p27 expression. miR-340 targets three key negative regulators of p27.
|
25151966 |
2015 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.
|
26874904 |
2016 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Scatter factor/hepatocyte growth factor stimulation of glioblastoma cell cycle progression through G(1) is c-Myc dependent and independent of p27 suppression, Cdk2 activation, or E2F1-dependent transcription.
|
11909963 |
2002 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Finally, TRAM-34 radiosensitized ectopic glioblastoma in vivo and high IK mRNA abundance associated with shorter patient OS in low-grade glioma and glioblastoma.
|
26041939 |
2015 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The compound-induced p27 reduction was also seen in three additional glioblastoma lines, T98G, U251 and U118 as well as in mouse embryonic fibroblasts.
|
17312389 |
2007 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Genetic variants of p21 and p27 and hepatocellular cancer risk in a Chinese Han population: a case-control study.
|
23034899 |
2013 |
|
Adult Liver Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Here, we determined the effects of p27 inactivation on disease progression and Cdk activation in mouse liver tumorigenesis that originates from hepatocyte regenerative proliferation in response to chronic liver injury, an established etiology in most human liver cancer.
|
17434927 |
2007 |
|
Adult Liver Carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Interrupting GSTP1 gene expression promoted liver cancer cell proliferation and increased the percentage of cells in S phase by decreasing levels of p21 and p27 and increasing p-Akt.
|
29507666 |
2018 |
|
Adult Liver Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Estrogen-related receptor γ is upregulated in liver cancer and its inhibition suppresses liver cancer cell proliferation via induction of p21 and p27.
|
26940882 |
2016 |
|
Adult Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Butyrate induced apoptosis of lymphoma tumor cells and significantly up-regulated histone 3 acetylation (H3ac) level and target genes such as Fas, P21, P27.
|
26885564 |
2016 |
|
Adult Medulloblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings provide a novel connection between REST and the proteasomal machinery in the control of p27 and cell proliferation in medulloblastoma cells.
|
22665064 |
2013 |
|
Adult Non-Hodgkin Lymphoma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In this study, we examined protein expression and methylation status of the promoter region of p27 in 70 cases with non-Hodgkin's lymphoma and their relationship with proliferative activity of the tumor cells as revealed by Ki-67 index.
|
12579309 |
2003 |
|
Adult Non-Hodgkin Lymphoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Different studies have already shown that the isolated inactivation of p21, p16, or p27 cyclin-dependent kinase inhibitors (CKIs) is associated with increased growth fraction, tumor progression, or decreased overall survival in cases of non-Hodgkin's lymphoma.
|
11438467 |
2001 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
To determine the role of p27 in tumorigenesis, we examined its mutational status in 74 non-Hodgkin's lymphomas (NHLs) (52 of B-cell phenotype, 22 of T-cell phenotype), 5 lymphoma cell lines, and 42 adult T-cell leukemias/lymphomas (ATLs) using polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and Southern blot analyses.
|
7655021 |
1995 |