Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
The close resemblance of prostate specific antigen, a marker for prostatic cancer, to glandular kallikrein suggests related immunogenic properties for them.
|
2470373 |
1989 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
PSA protein has been an important biological marker for prostate cancers.
|
1712248 |
1991 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
DNA ploidy and prostate-specific antigen as prognostic factors in clinically resectable prostate cancer.
|
1710533 |
1991 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Prostate-specific antigen (PSA) has emerged as the most useful marker for management of patients with prostate cancer.
|
1379363 |
1992 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Forty-three patients with untreated prostate cancer had serial PSA measurements over an average time span of 30 months.
|
7685704 |
1993 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We analyzed data from a cohort of 161 patients to determine whether there were any racial differences in PSA levels prior to treatment in local-regional prostate cancer.
|
1284591 |
1993 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
This autocrine PSA-inducing activity was found to be organ specific because CMs from other fibroblast cell lines (such as bone, prostate, kidney, and lung fibroblasts) and the CMs from several prostatic carcinoma cell lines (such as parental LNCaP, PC-3, DU-145) and a bladder transitional carcinoma cell line (WH) fail to exhibit similar activity.
|
7684949 |
1993 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
The authors used polymerase chain reaction (PCR) amplification of the prostate-specific antigen (PSA) mRNA sequence reverse-transcriptase PCR (RTPCR) and immunohistochemistry using a PSA antibody to identify metastatic prostate cancer cells in the bone marrow of patients with prostate cancer.
|
7522952 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Relationship of tumor DNA-ploidy to serum prostate-specific antigen doubling time after radiotherapy for prostate cancer.
|
7526527 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The present study was designed to elucidate the role of 13-cis-retinoic acid (RA) in regulation of PSA and the tumorigenic potential of the human prostate cancer cell line LNCaP.
|
7523313 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
However, serum PSA concentrations can be successfully used together with other methods in diagnosing prostatic diseases and in monitoring the successfulness of treatments for prostatic cancer.
|
7521173 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Newer applications of serum prostate-specific antigen in the management of prostate cancer.
|
7524153 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The serum prostate specific antigen (PSA) level was determined in 311 men with documented prostate cancer (stages T1cN0, T2N0 and T3N0) before bilateral pelvic lymphadenectomy and radical retropubic prostatectomy.
|
7514689 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this model, subcutaneous co-injection of 2 non-tumorigenic human cell lines--LNCaP, a prostate cancer cell line, and MS, a bone stromal cell-line--into intact adult male mice resulted in formation of carcinomas that secreted prostate-specific antigen (PSA), a clinically useful human serum prostate cancer marker.
|
8169003 |
1994 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
A molecular assay that detects prostate specific antigen (PSA)-synthesizing cells in the peripheral circulation of patients with prostate cancer is described.
|
8826922 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Human prostate-specific antigen (PSA) has been shown as an aid in the early detection of prostate cancer (W. J. Catalona et al., J.Am.Med.
|
7538903 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
The predictive value of nuclear DNA ploidy and AT on clinical and prostate-specific antigen (PSA) progression and on overall and cause-specific survival after radical retropubic prostatectomy was assessed in 894 patients with pT3 prostate cancer.
|
7544934 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
An RT-PCR-based assay for PSA mRNA can detect circulating cells in the peripheral blood of patients with prostatic cancer.
|
7537803 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Indeed, a new era of PSA testing has been entered, and the entire field of prostate cancer will benefit.
|
7538236 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Currently, the TNM (Tumor, Lymph Node, Metastasis) staging system, histologic grading (Gleason system), and serum prostate-specific antigen are recommended for general use as prognostic markers in prostate cancer.
|
7503660 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The use of a highly specific promoter-driven gene vector will allow selective expression of therapeutic genes within PSA-producing prostate cancer cells, providing a unique strategy for prostate cancer gene therapy.
|
8573614 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We have studied the expression of prostate-specific antigen (PSA) mRNA by reverse transcriptase-polymerase chain reaction in peripheral blood of 25 patients with cancer of the prostate (CAP), four with benign prostatic hyperplasia (BPH), two with renal stones, three with other types of cancer, and six healthy male and three female controls.
|
7533062 |
1995 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
We evaluated whether knowledge of preoperative free prostate-specific antigen (f-PSA), complexed (c-PSA), and total (t-PSA) concentrations or the ratios thereof (f-PSA/t-PSA, c-PSA/t-PSA, and f-PSA/c-PSA) could improve upon the staging of prostate cancer when compared with standard PSA testing (t-PSA).
|
8753736 |
1996 |
Malignant neoplasm of prostate
|
0.500 |
Biomarker
|
disease |
BEFREE |
Although similarities to PSA make hK2 a potential prostate cancer marker, they also impede biochemical characterization of hK2 in those human tissues and body fluids where PSA is abundant.
|
8968092 |
1996 |
Malignant neoplasm of prostate
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
We examined the antitumor effect of suramin in an in vivo mouse model of hormone-refractory human prostate cancer to determine whether a decrease in PSA levels reflects a reduction in tumor growth (volume).
|
8637045 |
1996 |