Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Genetic variants of apoptotic pathway-related factors (including PDCD1, PDCD1LG2, FAS, and FASLG) may affect apoptosis and in turn predict susceptibility to autoimmune disease.
|
31618754 |
2020 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis demonstrated that the FAS -670A/G and -1377 G/A polymorphisms were associated with the risk of autoimmune diseases.
|
31840751 |
2020 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The discovery that they are mutated in the fasl and the fas receptor gene, respectively, demonstrates the critical role of the FasL/Fas system in lymphocyte homeostasis and autoimmunity.
|
31072029 |
2019 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
FAS and RAS related Apoptosis defects: From autoimmunity to leukemia.
|
30565243 |
2019 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
We also generated biotinyl- and palmitoyl-labelled peptidomimetics, useful chemico-biological tools to further explore the pro-inflammatory signal of CD95, which plays an important role in the pathogenesis of lupus and other autoimmune diseases.
|
31301931 |
2019 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Moreover, altered expression of CD95 or its ligand causes autoimmunity and has also been directly involved in recurrent pregnancy losses and pregnancy disorders.
|
30702213 |
2019 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
FAS/FASL signaling system plays a vital role in the regulation of apoptosis, envisaged as a death process required for immune surveillance to prevent autoimmunity and tumorigenesis along with several other biological activities.
|
29611722 |
2018 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Autoimmune lymphoproliferative syndrome (ALPS) with FAS mutation (ALPS-FAS) is a nonmalignant, noninfectious, lymphoproliferative disease with autoimmunity.
|
29686686 |
2018 |
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Increased activation of CD95/Fas by Fas ligand in viral hepatitis and autoimmunity is involved in pathogenesis of fulminant hepatitis and liver failure.
|
28060213 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Retro-transposon insertion into the second intron of the pro-apoptotic Fas gene appears to be responsible for both lymphoproliferation and autoimmunity, while other genes are more likely to contribute to the regenerative healing characteristic of this mouse strain.
|
27837196 |
2017 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Autoimmune lymphoproliferative syndrome (ALPS) is a well-characterized pediatric autoimmune disease caused by mutations in genes associated with the FAS-dependent apoptosis pathway.
|
27845235 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
CD95 (Fas-ligand) is a key mediator of cell death in multiple setting, thus its loss within the MRL-lpr (Fas<sup>lpr</sup>) homozygote mice results in spontaneous autoimmunity.
|
28078597 |
2017 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Our data uncover a defect in B-cell selection in patients with FAS mutations, which has implications for the understanding of the pathogenesis of autoimmunity and lymphomagenesis of autoimmune lymphoproliferative syndrome.
|
26907631 |
2016 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Therapeutic targeting of BET protein BRD4 delays murine lupus.
|
26590112 |
2015 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
FAS and FAS ligand (FASLG) are important proapoptotic proteins that have a significant function in regulating cell growth and apoptosis and play essential roles in many human autoimmune diseases.
|
23591741 |
2013 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although it has not yet been possible to assign any particular allele or genotype to the control of FAS expression, this polymorphism has been described to be associated with several autoimmune diseases including LE.
|
22299671 |
2012 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Defects in the peripheral taste structure and function in the MRL/lpr mouse model of autoimmune disease.
|
22536412 |
2012 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The Fas/CD95 surface receptor mediates rapid death of various cell types, including autoreactive T cells with the potential for triggering autoimmunity.
|
19770844 |
2010 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The TNFRSF-6 gene encoding Fas is mutated in children suffering from autoimmune lymphoproliferative syndrome (ALPS), which is characterized by lymphoproliferation and autoimmunity.
|
17724145 |
2007 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Inherited and acquired defects in the Fas gene, TNFRSF6 (tumor necrosis factor receptor superfamily member 6) have been associated with human autoimmune lymphoproliferative syndrome (ALPS) and a spectrum of other complex autoimmune diseases and malignancies.
|
16271851 |
2006 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Fas polymorphisms influence susceptibility to autoimmune hepatitis.
|
15929764 |
2005 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Fas (CD95, APO-1, TNFRSF6) is a TNF receptor superfamily member that directly triggers apoptosis and contributes to the maintenance of lymphocyte homeostasis and prevention of autoimmunity.
|
15557123 |
2004 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Due to the functional relevance of the Fas pathway in autoimmune thyroid disease we were interested in the possible contribution of polymorphisms in the Fas gene to the genetic risk of thyroid autoimmunity, which so far is mainly, but incompletely, attributed to the HLA DQ region and polymorphisms in the CTLA-4 gene.
|
14585083 |
2003 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
LHGDN |
Death receptor Fas and autoimmune disease: from the original generation to therapeutic application of agonistic anti-Fas monoclonal antibody.
|
12220552 |
2003 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Hence, as has been demonstrated for CD95-deficient mice, also GC-derived autoreactive B cells carrying somatic CD95 gene mutations may potentially service negative selection and participate in the development of autoimmune diseases.
|
12516573 |
2002 |