IL1A, interleukin 1 alpha, 3552

N. diseases: 1002; N. variants: 19
Disease: Stomach Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 GeneticVariation disease BEFREE The pro-inflammatory cytokine IL-1β plays a crucial role in the development of gastric tumors, and polymorphisms in the IL-1 gene cluster resulting in increased IL-1β production have been associated with increased risk for gastric cancer. 27460807 2016
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE There was a positive correlation between IL-1α, which was upregulated during hypoxia, and tumor stage, lymph node metastasis and resistance to cisplatin in GC. 28608600 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.100 Biomarker disease BEFREE The IL-1RA downregulated the metastatic potential of gastric cancer through blockage of the IL-1α/VEGF signaling pathways. 29344744 2018