IL1A, interleukin 1 alpha, 3552

N. diseases: 1002; N. variants: 19
Disease: Chorioamnionitis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0008495
Disease: Chorioamnionitis
Chorioamnionitis 		0.320 Biomarker phenotype BEFREE IL-1 is a potential therapeutic target for chorioamnionitis and associated morbidities. 29563340 2018
CUI: C0008495
Disease: Chorioamnionitis
Chorioamnionitis 		0.320 AlteredExpression phenotype BEFREE C57BL/6 infected animals predominantly exhibited mild to moderate chorioamnionitis (P<0.0001), and a significant reduction in placental expression of IL-1α, IL-1β, IL-6, TNF-α, S100A8, and S100A9 compared to sham controls (P<0.02). 22952869 2012
CUI: C0008495
Disease: Chorioamnionitis
Chorioamnionitis 		0.320 Biomarker phenotype CTD_human We conclude that IL-1 and LPS both can cause chorioamnionitis, but IL-1 is not an important mediator of LPS-induced chorioamnionitis in fetal sheep. 21493953 2011